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Designer drugs : chemistry, analysis, regulation, toxicology, epidemiology & legislation of new psychoactive substances /

A title in the Emerging Issues in Analytical Chemistry series, Designer Drugs: Chemistry, Analysis, Regulation, Toxicology, Epidemiology & Legislation of New Psychoactive Substances presents both an overview and a guide to techniques for designer drug analysis. Proliferation of the synthesis and...

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Bibliographic Details
Main Author: Gerona, Roy (Author)
Corporate Author: ScienceDirect (Online service)
Format: eBook
Language:English
Published: Amsterdam, Netherlands : Elsevier, [2024].
Subjects:
Designer drugs.
Designer Drugs
Drogues de confection.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Front Cover
  • DESIGNER DRUGS
  • DESIGNER DRUGSCHEMISTRY, ANALYSIS, REGULATION, TOXICOLOGY, EPIDEMIOLOGY &amp
  • LEGISLATION OF NEW PSYCHOACTIVE SUBSTANCESROY GER ...
  • Copyright
  • Dedication
  • Contents
  • Foreword
  • Preface
  • Acknowledgments
  • 1
  • NPS origins and use
  • Definition
  • Origins
  • The 21st-century resurgence
  • Synthetic cannabinoids
  • Synthetic cathinones
  • New synthetic opioids
  • Designer benzodiazepines
  • Other classes
  • Production, marketing, and supply
  • Patterns of use, effects, and toxicity
  • Detection and identification of use
  • Control and regulation
  • References
  • 2
  • NPS chemistry, classification, and metabolism
  • Current classification systems
  • Pharmacological classification
  • Legal classification
  • Classification based on origin
  • Chemical classification
  • A proposed NPS classification
  • Metabolic transformations of common NPS classes
  • Amphetamines and phenethylamines
  • Synthetic cathinones
  • Synthetic cannabinoids
  • New synthetic opioids
  • Designer benzodiazepines
  • References
  • 3
  • NPS pharmacology and toxicology
  • Acute toxicity and long-term effects
  • Synthetic cannabinoids
  • Synthetic cathinones
  • Amphetamines and phenethylamines
  • Other stimulants and psychedelics
  • Aminoindanes
  • Benzofurans
  • Tryptamines
  • Piperazines
  • Piperidines
  • Dissociatives
  • New synthetic opioids
  • Designer benzodiazepines
  • References
  • 4
  • NPS analysis
  • Workflow
  • Chain of custody and documentation
  • Sample matrices
  • Urine
  • Blood
  • Hair
  • Oral fluid
  • Dried blood spot
  • Others
  • Sample preparation strategies
  • Protein precipitation
  • Liquid-liquid extraction
  • Solid-phase extraction
  • Presumptive and confirmatory analyses
  • References
  • 5
  • NPS screening
  • Screening platforms
  • Colorimetric assays (spot tests)
  • Immunoassays
  • Synthetic cannabinoids.
  • Stimulants, psychedelics, and dissociatives
  • New synthetic opioids and designer benzodiazepines
  • References
  • 6
  • NPS confirmation using targeted analysis
  • Confirmatory analysis
  • Liquid chromatography-tandem mass spectrometry
  • Liquid chromatography
  • Mass spectrometry
  • Ion source
  • Mass analyzer
  • Mass detector
  • Drug identification and quantitation using LC-MS/MS
  • Use in NPS analysis
  • Broad-spectrum NPS analysis
  • Synthetic cannabinoids
  • Stimulants, psychedelics, and dissociatives
  • New synthetic opioids and designer benzodiazepines
  • References
  • 7
  • NPS analysis using high-resolution mass spectrometry
  • HRMS platforms and role in NPS analysis
  • Instrumental analysis techniques
  • Data acquisition strategies
  • Data-dependent acquisition
  • Data-independent acquisition
  • Data processing techniques
  • Targeted analysis
  • Suspect screening
  • Nontargeted analysis
  • Laboratory application of LC-HRMS analysis
  • Use in NPS analysis
  • LC-TOF/MS
  • LC-QTOF/MS
  • Data-dependent acquisition strategies
  • Data-independent acquisition strategies
  • Advantages and limitations of LC-HRMS
  • References
  • 8
  • NPS surveillance and epidemiology
  • Sampling strategies
  • Surveillance systems
  • Global surveillance and UNODC
  • Europe
  • The Early Warning System
  • Three periods of the EWS
  • 1997 to 2007
  • 2008 to 2015
  • 2016 to 2022
  • STRIDA
  • Euro-DEN
  • The United States
  • Poison control center reports
  • National Forensic Laboratory Information System
  • NFLIS-drug reports
  • Survey of toxicology laboratories
  • Multidisciplinary NPS testing
  • Prophetic synthetic cannabinoids library
  • DEA TOX
  • Other surveillance systems
  • Changing motivations and patterns of use
  • References
  • 9
  • NPS regulation and legislation
  • Challenges
  • Control of psychoactive drugs: International drug laws.
  • Control of psychoactive drugs: Scheduling in the United States
  • The European framework for NPS control
  • Scheduling strategies in Asia and Oceania
  • Generic legislation and blanket ban
  • References
  • Index
  • Back Cover.