Strategies for overcoming chemotherapy resistance in cervical cancer from molecular insights to precision solutions /
Strategies for Overcoming Chemotherapy Resistance in Cervical Cancer: From Molecular Insights to Precision Solutions, Volume 21 highlights different strategies to reverse chemotherapy resistance in cervical cancer. The book puts a strong focus on strategies to reverse chemotherapy resistance as well...
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| Format: | eBook |
| Language: | English |
| Published: |
London :
Academic Press,
2024.
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| Series: | Cancer Sensitizing Agents for Chemotherapy ;
21 |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Intro
- Strategies for Overcoming Chemotherapy Resistance in Cervical Cancer: From Molecular Insights to Precision Solutions
- Copyright
- Cover Image Legend
- Aims and Scope for Series ``Cancer Sensitizing Agents for Chemotherapy´´
- About the Series Editor
- Aims and Scope of the Volume
- About the Volume Editor
- Preface
- Contents
- Contributors
- Chapter 1: An overview of cervical cancer, chemotherapy as treatment and chemotherapy resistance
- Introduction
- Staging for cervical cancer
- The role of chemotherapy in the treatment of cervical cancer
- Mode of action: Cisplatinum
- The role of immunotherapy in the treatment of cervical cancer
- Mode of action: Immunotherapy
- Understanding the pathway for chemotherapy resistance
- DNA methylation
- Aberrant repair pathways
- Stemness
- Tumor microenvironment
- Hypoxia
- Classification of cisplatin resistance
- Pretarget resistance
- On-target resistance
- Posttarget resistance
- Off-target resistance
- Overcoming chemotherapy resistance for future management of cervical cancer
- Epigenetic regulators, and molecular therapies
- Natural products from plants, and bioactive metabolites from micro-organisms used to overcome cancer resistance
- Challenges for overcoming chemotherapy resistance in cervical cancer
- Conclusion
- References
- Chapter 2: Current treatment options and limitations for cervical cancer
- Introduction-Current approach to cervical cancer therapies
- Chemotherapy regimens and their effectiveness
- Targeted therapies and immunotherapies
- Combination therapies and clinical trials
- Limitations of current treatment options
- Conclusions
- References
- Chapter 3: Radiotherapy treatment resistance in cervical cancer
- Introduction
- Conventional clinical-pathological factors
- Patient-related factors
- Treatment-related factors.
- Tumor-related factors
- Genomic markers of lymph node metastases
- Pathological tumor type and treatment resistance
- HPV and treatment resistance
- HPV subtype
- HPV viral load
- HPV integration
- Tumor hypoxia
- Genetic alterations associated with treatment response
- Limitations
- Conclusion
- References
- Chapter 4: Mechanisms of chemotherapy resistance in cervical cancer
- Background
- The tumor microenvironment (TME) as an enabling environment in CC chemoresistance
- Cancer stem cell activation
- Cancer associated fibroblasts (CAFs) and immune cells
- Tumor hypoxia in chemoresistance
- Signaling pathways and epigenetics in CC chemoresistance
- P53 pathway
- PIP3K/Akt/MAPK pathway
- EGFR pathway
- Hippo pathway
- SH3BP1 pathway
- Metabolic alterations in chemoresistance
- Combinatorial therapies in overcoming CC
- Limitations and challenges of targeting cellular and molecular mechanisms in CC chemoresistance
- Conclusions
- References
- Chapter 5: Reversal of resistance mechanisms in cervical cancer
- Introduction
- Identification of resistance mechanisms
- Reduced uptake
- Increased efflux
- Thiol-containing protein-mediated inactivation
- Increased DNA repair
- Nucleotide excision repair
- DNA mismatch repair
- Inactivation of apoptosis pathways
- Activation of EMT
- Epigenetic factors
- Stress response chaperones
- Development of novel drugs and methods to target resistance mechanisms
- Novel drugs for cervical cancer treatment
- Overcoming resistance by drug delivery mechanisms
- Liposomes
- Hydrogels
- Nanoparticles
- Repurposing of existing drugs
- Combination therapies to overcome resistance
- Conclusion
- References
- Chapter 6: HPV- and HIV-associated epigenetic silencing in cervical cancer: Targets for overcoming chemoresistance
- Introduction
- HPV, HIV, and cervical cancer.
- Mechanisms of HPV/HIV interaction in cervical cancer at a molecular level
- HPV/host epigenetic modifications leading to chemoresistance in cervical cancer
- DNA methylation and chemoresistance in cervical cancer
- HPV genome methylation
- Host genome methylation
- Host methylation of apoptosis-associated genes
- Host methylation of cell cycle-associated genes
- DNA methylation of cell adhesion-associated genes
- DNA methylation of cell differentiation and proliferation-associated genes
- DNA methylation of DNA repair-associated genes
- DNA methylation of cell signaling-associated genes
- Histone acetylation
- HPV histone acetylation
- Host histone acetylation
- Potential epigenetic biomarkers for cervical cancer treatment
- Challenges and limitations of epigenetic biomarkers for cervical cancer treatment
- Conclusion and future perspective
- References
- Chapter 7: Splicing-associated chemotherapy resistance in cervical cancer: Targeting splicing signatures
- Introduction
- Alternative splicing as a normal biological process
- Dysregulated alternative splicing in cervical neoplasia and alterations in splicing regulatory factors
- Alterations in splicing factors in CC
- Alterations in hnRPNs in CC
- Splicing and chemoresistance in CC
- Deregulation of splicing factors leads to chemotherapy resistance in CC
- CeRNA networks promote chemoresistance through alternative splicing regulation
- LncRNAs splicing switch in CC chemoresistance
- CircRNAs splicing switch in CC chemoresistance
- siRNAs splicing switch in CC chemoresistance
- PiRNAs splicing switch in CC chemoresistance
- Limitations and challenges of targeting splicing signatures in alleviating CC chemoresistance
- Conclusion
- References.
- Chapter 8: MicroRNA involvement in cervical cancer chemotherapy drug resistance: Restoring sensitivity to chemotherapeuti ...
- Introduction
- MicroRNAs-The potential cervical cancer treatment
- Chemotherapy resistance and sensitivity
- Application of miRNA in diagnosis and prognosis of cervical cancer
- Challenges and limitations
- Conclusion
- References
- Chapter 9: Future directions in cervical cancer treatment
- Introduction
- The roadmap to elimination of cervical cancer by 2030
- Personalized medicine and precision oncology
- Nanocarrier and drug-based delivery systems
- Radiopharmaceutical therapy
- Computational oncology
- Artificial intelligence
- Computational intelligence
- Molecular targeted therapies
- Monoclonal antibodies
- Gene therapy
- Indigenous knowledge systems
- Identification of biomarkers for resistance
- Challenges and limitations
- Conclusion
- References
- Chapter 10: Conclusion: Overcoming chemoresistance in cervical cancer
- Index.