Cover Image

Functionalized magnetic nanosystems for diagnostic tools and devices : current and emerging research trends /

Functionalized Magnetic Nanosystems for Diagnostic Tools and Devices: Current and Emerging Research Trends explores the various aspects of functionalization of magnetic nanosystems in great detail, providing a thorough review of the associated benefits and challenges.

Bibliographic Details
Corporate Author: ScienceDirect (Online service)
Other Authors: Deshmukh, Kalim (Editor), Hussain, Chaudhery Mustansar (Editor)
Format: eBook
Language:English
Published: Amsterdam : Elsevier, 2024.
Series:Micro and nanomanufacturing series.
Subjects:
Nanotechnology.
Magnetic nanoparticles.
Nanotechnologie.
Nanotechnology
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Intro
  • Functionalized Magnetic Nanosystems for Diagnostic Tools and Devices
  • Copyright
  • Contents
  • Contributors
  • Chapter 1: Introduction to magnetic nanosystems: Classifications, structure, properties, biological interactions, and dia ...
  • 1. Introduction
  • 2. Definition of magnetic nanoparticles and nanomagnetism
  • 3. Synthesis of magnetic nanoparticles
  • 4. Physicochemical features and characterization
  • 4.1. Size and shape
  • 4.1.1. Cuboid shapes
  • 4.1.2. Elongated shapes
  • 4.1.3. Disk shapes
  • 4.1.4. Flower-like shapes
  • 4.1.5. Other shapes
  • 4.2. Structure and surface effect
  • 4.3. Composition
  • 4.3.1. Monocomponent magnetic nanostructures
  • 4.3.1.1. Metal alloy nanostructures
  • 4.3.1.2. Metal oxide magnetic nanostructures
  • 4.3.1.3. Metal carbide magnetic nanostructures
  • 4.3.2. Multicomponent magnetic structures
  • 4.3.2.1. Heterostructure magnetic nanostructures
  • 4.3.2.2. Exchange-coupled magnetic nanostructures
  • 4.4. Surface thermodynamics
  • 4.5. Colloidal stability
  • 5. Structural classification of magnetic nanoparticles
  • 6. Biological interactions
  • 6.1. Biocompatibility
  • 6.2. Targeting ability
  • 6.3. Toxicity
  • 7. Diagnostic applications
  • 7.1. Magnetic resonance imaging (MRI)
  • 7.2. Magnetic particle imaging (MPI)
  • 7.3. Tissue engineering
  • 7.4. Biosensing applications
  • 8. Challenges and future perspectives
  • 9. Conclusion
  • References
  • Chapter 2: Synthesis and processing methods of magnetic nanosystems for diagnostic tools and devices: Design strategies a ...
  • 1. Introduction
  • 2. Fundamental characteristics, barriers, and endocytosis mechanism of MNPs
  • 2.1. In vivo barriers for MNPs
  • 2.2. In vivo navigation of MNPs
  • 3. Targeting strategy of MNPs via active and passive approach
  • 4. Various methods of MNPs synthesis
  • 4.1. Physical method of MNPs synthesis.
  • 4.1.1. Ball milling method of MNPs synthesis
  • 4.1.2. Laser evaporation of MNPs synthesis
  • 4.1.3. Wire explosion method of MNPs synthesis
  • 4.1.4. Thermal decomposition method
  • 4.2. Chemical method of MNPs synthesis
  • 4.2.1. Microemulsion method of MNPs synthesis
  • 4.2.2. Sol-gel method of MNPs synthesis
  • 4.2.3. Hydrothermal method of MNPs synthesis
  • 4.2.4. Co-precipitation method
  • 4.3. Biological method of MNPs synthesis
  • 5. Dendrimer-encapsulated-(DE)-MNPs: Synthesis and characterization
  • 6. Medical use of MNPs for diagnosis and imaging of diseases
  • 6.1. As a magnetic resonance imaging contrast agent for imaging of various medical conditions
  • 6.2. Usage of MNPs as a molecular diagnostic agent
  • 6.2.1. Nucleic acid separation and detection with the help of MNPs
  • 6.2.2. Protein purification by magnetophoretic processes
  • 6.2.3. Immunomagnetic cell separation by using MNPs
  • 7. Ongoing and finished clinical trials of MNPs
  • 8. Limitation of MNPs to be used in preclinical and clinical studies
  • 9. Challenges and future prospective
  • 10. Conclusion
  • Conflict of interest
  • References
  • Chapter 3: Surface functionalization and modification strategies of magnetic nanosystems
  • 1. Introduction
  • 1.1. Nanomaterials
  • 1.2. Magnetic nanomaterials
  • 1.3. Metal oxide nanomaterials
  • 2. Magnetic iron oxide nanomaterials
  • 2.1. Synthesis routes of magnetic iron oxide nanoparticles
  • 2.1.1. Coprecipitation
  • 2.1.2. Sol-gel method
  • 2.1.3. Microwave irradiation
  • 2.1.4. Microemulsion
  • 2.1.5. Hydrothermal
  • 2.1.6. Solvothermal
  • 2.1.7. Thermal decomposition
  • 2.1.8. Sonolysis
  • 2.2. Synthesis of functionalized magnetic iron oxide nanoparticles
  • 2.2.1. Polymer-based modifications of magnetic nanoparticles
  • 2.2.2. Biomolecule modification on magnetic iron oxide nanoparticles.
  • Chapter 5: Biocompatibility and toxicity assessments of functionalized magnetic nanosystems
  • 1. Introduction
  • 2. Magnetic nanosystems in nanotechnology
  • 2.1. Biomedical applications of magnetic nanoparticles
  • 3. Different members of the magnetic nanosystems
  • 4. Concept of biocompatibility
  • 4.1. Histocompatibility
  • 4.2. Biochemical compatibility
  • 5. Toxicity
  • 5.1. Toxicity of magnetic nanoparticles
  • 5.2. Toxicity profile of various nanoparticles in various organs
  • 5.3. Different methods used to study the toxicity of MNPs
  • 5.3.1. Propidium iodide fluorescence assay
  • 5.3.2. Bromodeoxyuridine incorporation assay
  • 5.3.3. Trypan blue dye exclusion assay
  • 5.3.4. Lactate dehydrogenase cytotoxicity assay
  • 5.3.5. MTT assay
  • 6. Concept of nanotoxicology
  • 6.1. Nanotoxicity of magnetic nanosystem
  • 6.1.1. Genotoxicity
  • 6.1.2. Cytotoxicity
  • 6.1.3. Biochemical toxicity
  • 6.1.4. Histological toxicity
  • 6.2. Importance of toxicity assessments in magnetic nanosystems
  • 7. Future prospectives
  • 8. Conclusions
  • Acknowledgments
  • References
  • Chapter 6: Functionalized magnetic nanosystems for diagnostic tools and devices: New perspectives in disease diagnosis
  • 1. Introduction
  • 2. Surface modification approaches of MNPs
  • 2.1. Organic molecules-based surface modification
  • 2.2. Inorganic molecules-based surface modification
  • 2.3. Macromolecules-based surface modification
  • 3. MNPs as diagnostic tools
  • 3.1. MRI enhancement with MNPs
  • 3.2. Magnetic labeling
  • 3.3. Magnetic separation and purification
  • 3.4. Biosensors
  • 3.5. Lab-on-chip (LOC)
  • 3.6. Microfluidics
  • 3.7. Lateral-flow immunoassay
  • 4. Future perspectives and conclusion
  • References
  • Chapter 7: Functionalized magnetic nanosystems for point-of-care and point-of-need diagnostic applications
  • 1. Introduction
  • 2. Imaging applications.
  • 3. Molecular diagnostic applications
  • 4. Applications in biorecognition
  • 5. Biosensing applications
  • 6. Microfluidics/lab-on-a-chip
  • 7. Point-of-need diagnostics in epidemics
  • 8. Challenges and future perspectives
  • 9. Conclusion
  • References
  • Chapter 8: Functionalization of biogenic and biomimetic magnetic nanosystems for biomedical applications
  • 1. Introduction
  • 1.1. Magnetic properties
  • 1.2. Superparamagnetism
  • 2. Synthesis of biogenic MNPs
  • 3. Physicochemical and structural characterization of magnetic nanoparticles
  • 4. Magnetic nanoparticles in biomedical applications
  • 4.1. Tissue engineering
  • 4.2. Imaging modalities
  • 4.2.1. Magnetic resonance imaging (MRI)
  • 4.2.2. Computed tomography (CT scan)
  • 4.2.3. Positron emission tomography (PET)
  • 4.2.4. Magnetic particle imaging (MPI)
  • 4.3. Lab on-chip (LOC) system
  • 4.4. Biosensors
  • 4.5. Magnetic nanoparticle-based hyperthermia (MNP-H)
  • 5. Challenges and future perspectives
  • 6. Conclusion
  • Acknowledgment
  • References
  • Chapter 9: Functionalized magnetic nanosystems for cancer diagnosis and therapy
  • 1. Introduction
  • 2. Magnetic nanosystems: Synthesis and their functionalization
  • 2.1. Synthesis
  • 2.2. Functionalization
  • 3. Functionalized magnetic nanosystems for cancer diagnosis
  • 4. Functionalized magnetic nanosystems for cancer therapy
  • 5. Functionalized magnetic nanosystems for theranostics
  • 6. Challenges and future perspective
  • 7. Conclusion
  • References
  • Chapter 10: Functionalized magnetic nanosystems for immobilization of proteins and enzymes
  • 1. Introduction
  • 2. Protein and enzyme immobilized functionalized magnetic nanosystems
  • 2.1. Nanoparticles
  • 2.2. Nanotubes
  • 2.3. Nanocapsules
  • 2.4. Nanofibers
  • 2.5. Nanorods
  • 2.6. Nanocrystals
  • 2.7. Carbon quantum dots
  • 3. Conclusion and future perspectives
  • References.