http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Functionalized magnetic nanosystems for diagnostic tools and devices
Functionalized Magnetic Nanosystems for Diagnostic Tools and Devices: Current and Emerging Research Trends explores the various aspects of functionalization of magnetic nanosystems in great detail, providing a thorough review of the associated benefits and challenges.
Intro -- Functionalized Magnetic Nanosystems for Diagnostic Tools and Devices -- Copyright -- Contents -- Contributors -- Chapter 1: Introduction to magnetic nanosystems: Classifications, structure, properties, biological interactions, and dia ... -- 1. Introduction -- 2. Definition of magnetic nanoparticles and nanomagnetism -- 3. Synthesis of magnetic nanoparticles -- 4. Physicochemical features and characterization -- 4.1. Size and shape -- 4.1.1. Cuboid shapes -- 4.1.2. Elongated shapes -- 4.1.3. Disk shapes -- 4.1.4. Flower-like shapes -- 4.1.5. Other shapes -- 4.2. Structure and surface effect -- 4.3. Composition -- 4.3.1. Monocomponent magnetic nanostructures -- 4.3.1.1. Metal alloy nanostructures -- 4.3.1.2. Metal oxide magnetic nanostructures -- 4.3.1.3. Metal carbide magnetic nanostructures -- 4.3.2. Multicomponent magnetic structures -- 4.3.2.1. Heterostructure magnetic nanostructures -- 4.3.2.2. Exchange-coupled magnetic nanostructures -- 4.4. Surface thermodynamics -- 4.5. Colloidal stability -- 5. Structural classification of magnetic nanoparticles -- 6. Biological interactions -- 6.1. Biocompatibility -- 6.2. Targeting ability -- 6.3. Toxicity -- 7. Diagnostic applications -- 7.1. Magnetic resonance imaging (MRI) -- 7.2. Magnetic particle imaging (MPI) -- 7.3. Tissue engineering -- 7.4. Biosensing applications -- 8. Challenges and future perspectives -- 9. Conclusion -- References -- Chapter 2: Synthesis and processing methods of magnetic nanosystems for diagnostic tools and devices: Design strategies a ... -- 1. Introduction -- 2. Fundamental characteristics, barriers, and endocytosis mechanism of MNPs -- 2.1. In vivo barriers for MNPs -- 2.2. In vivo navigation of MNPs -- 3. Targeting strategy of MNPs via active and passive approach -- 4. Various methods of MNPs synthesis -- 4.1. Physical method of MNPs synthesis.
4.1.1. Ball milling method of MNPs synthesis -- 4.1.2. Laser evaporation of MNPs synthesis -- 4.1.3. Wire explosion method of MNPs synthesis -- 4.1.4. Thermal decomposition method -- 4.2. Chemical method of MNPs synthesis -- 4.2.1. Microemulsion method of MNPs synthesis -- 4.2.2. Sol-gel method of MNPs synthesis -- 4.2.3. Hydrothermal method of MNPs synthesis -- 4.2.4. Co-precipitation method -- 4.3. Biological method of MNPs synthesis -- 5. Dendrimer-encapsulated-(DE)-MNPs: Synthesis and characterization -- 6. Medical use of MNPs for diagnosis and imaging of diseases -- 6.1. As a magnetic resonance imaging contrast agent for imaging of various medical conditions -- 6.2. Usage of MNPs as a molecular diagnostic agent -- 6.2.1. Nucleic acid separation and detection with the help of MNPs -- 6.2.2. Protein purification by magnetophoretic processes -- 6.2.3. Immunomagnetic cell separation by using MNPs -- 7. Ongoing and finished clinical trials of MNPs -- 8. Limitation of MNPs to be used in preclinical and clinical studies -- 9. Challenges and future prospective -- 10. Conclusion -- Conflict of interest -- References -- Chapter 3: Surface functionalization and modification strategies of magnetic nanosystems -- 1. Introduction -- 1.1. Nanomaterials -- 1.2. Magnetic nanomaterials -- 1.3. Metal oxide nanomaterials -- 2. Magnetic iron oxide nanomaterials -- 2.1. Synthesis routes of magnetic iron oxide nanoparticles -- 2.1.1. Coprecipitation -- 2.1.2. Sol-gel method -- 2.1.3. Microwave irradiation -- 2.1.4. Microemulsion -- 2.1.5. Hydrothermal -- 2.1.6. Solvothermal -- 2.1.7. Thermal decomposition -- 2.1.8. Sonolysis -- 2.2. Synthesis of functionalized magnetic iron oxide nanoparticles -- 2.2.1. Polymer-based modifications of magnetic nanoparticles -- 2.2.2. Biomolecule modification on magnetic iron oxide nanoparticles.
Chapter 5: Biocompatibility and toxicity assessments of functionalized magnetic nanosystems -- 1. Introduction -- 2. Magnetic nanosystems in nanotechnology -- 2.1. Biomedical applications of magnetic nanoparticles -- 3. Different members of the magnetic nanosystems -- 4. Concept of biocompatibility -- 4.1. Histocompatibility -- 4.2. Biochemical compatibility -- 5. Toxicity -- 5.1. Toxicity of magnetic nanoparticles -- 5.2. Toxicity profile of various nanoparticles in various organs -- 5.3. Different methods used to study the toxicity of MNPs -- 5.3.1. Propidium iodide fluorescence assay -- 5.3.2. Bromodeoxyuridine incorporation assay -- 5.3.3. Trypan blue dye exclusion assay -- 5.3.4. Lactate dehydrogenase cytotoxicity assay -- 5.3.5. MTT assay -- 6. Concept of nanotoxicology -- 6.1. Nanotoxicity of magnetic nanosystem -- 6.1.1. Genotoxicity -- 6.1.2. Cytotoxicity -- 6.1.3. Biochemical toxicity -- 6.1.4. Histological toxicity -- 6.2. Importance of toxicity assessments in magnetic nanosystems -- 7. Future prospectives -- 8. Conclusions -- Acknowledgments -- References -- Chapter 6: Functionalized magnetic nanosystems for diagnostic tools and devices: New perspectives in disease diagnosis -- 1. Introduction -- 2. Surface modification approaches of MNPs -- 2.1. Organic molecules-based surface modification -- 2.2. Inorganic molecules-based surface modification -- 2.3. Macromolecules-based surface modification -- 3. MNPs as diagnostic tools -- 3.1. MRI enhancement with MNPs -- 3.2. Magnetic labeling -- 3.3. Magnetic separation and purification -- 3.4. Biosensors -- 3.5. Lab-on-chip (LOC) -- 3.6. Microfluidics -- 3.7. Lateral-flow immunoassay -- 4. Future perspectives and conclusion -- References -- Chapter 7: Functionalized magnetic nanosystems for point-of-care and point-of-need diagnostic applications -- 1. Introduction -- 2. Imaging applications.
3. Molecular diagnostic applications -- 4. Applications in biorecognition -- 5. Biosensing applications -- 6. Microfluidics/lab-on-a-chip -- 7. Point-of-need diagnostics in epidemics -- 8. Challenges and future perspectives -- 9. Conclusion -- References -- Chapter 8: Functionalization of biogenic and biomimetic magnetic nanosystems for biomedical applications -- 1. Introduction -- 1.1. Magnetic properties -- 1.2. Superparamagnetism -- 2. Synthesis of biogenic MNPs -- 3. Physicochemical and structural characterization of magnetic nanoparticles -- 4. Magnetic nanoparticles in biomedical applications -- 4.1. Tissue engineering -- 4.2. Imaging modalities -- 4.2.1. Magnetic resonance imaging (MRI) -- 4.2.2. Computed tomography (CT scan) -- 4.2.3. Positron emission tomography (PET) -- 4.2.4. Magnetic particle imaging (MPI) -- 4.3. Lab on-chip (LOC) system -- 4.4. Biosensors -- 4.5. Magnetic nanoparticle-based hyperthermia (MNP-H) -- 5. Challenges and future perspectives -- 6. Conclusion -- Acknowledgment -- References -- Chapter 9: Functionalized magnetic nanosystems for cancer diagnosis and therapy -- 1. Introduction -- 2. Magnetic nanosystems: Synthesis and their functionalization -- 2.1. Synthesis -- 2.2. Functionalization -- 3. Functionalized magnetic nanosystems for cancer diagnosis -- 4. Functionalized magnetic nanosystems for cancer therapy -- 5. Functionalized magnetic nanosystems for theranostics -- 6. Challenges and future perspective -- 7. Conclusion -- References -- Chapter 10: Functionalized magnetic nanosystems for immobilization of proteins and enzymes -- 1. Introduction -- 2. Protein and enzyme immobilized functionalized magnetic nanosystems -- 2.1. Nanoparticles -- 2.2. Nanotubes -- 2.3. Nanocapsules -- 2.4. Nanofibers -- 2.5. Nanorods -- 2.6. Nanocrystals -- 2.7. Carbon quantum dots -- 3. Conclusion and future perspectives -- References.
edited by Kalim Deshmukh, Chaudhery Mustansar Hussain.