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Curcumin-based nanomedicines as cancer therapeutics.

Curcumin-Based Nanomedicines as Cancer Therapeutics presents a consistent and thorough overview of nanocurcumin applications in cancer treatments. It brings together the novel applications of nanocurcumin in biological milieu as well as helps readers to define the major gaps in knowledge that can le...

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Bibliographic Details
Corporate Author: ScienceDirect (Online service)
Format: eBook
Language:English
Published: [S.l.] : Academic Press, 2024.
Subjects:
Nanomedicine.
Cancer > Treatment > Technological innovations.
Curcumin > Therapeutic use.
Nanomedicine
Nanomédecine.
Curcumine > Emploi en thérapeutique.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Front Cover
  • Curcumin-Based Nanomedicines as Cancer Therapeutics
  • Copyright Page
  • Contents
  • List of contributors
  • A. Curcumin: Introduction, structure, and physicochemical attributes
  • 1 Curcumin: historical background, introduction, structure, and physicochemical attributes
  • 1.1 Historical background
  • 1.2 Characteristics
  • 1.3 Components
  • 1.4 Benefits, pharmacological effect, and potential therapeutic effect of turmeric and its major compound curcumin
  • 1.4.1 Antiinflammation activity
  • 1.4.2 Antioxidant activity
  • 1.4.3 Protective effects on cardiovascular disease
  • 1.4.4 Antidiabetic properties
  • 1.4.5 Effect on the gastrointestinal tract
  • 1.4.6 Effect on the skin
  • 1.4.7 Neuroprotective effect
  • 1.4.8 Hepatoprotective effect
  • 1.4.9 Anticancer effect
  • 1.4.10 Antimicrobial properties
  • 1.5 Toxicity
  • 1.6 Conclusion
  • Conflict of interests
  • References
  • 2 Curcumin as a pharmaceutical leader
  • 2.1 Introduction
  • 2.2 Therapeutic activities of curcumin
  • 2.2.1 Curcumin and neurological diseases
  • 2.2.2 Curcumin and cardiovascular diseases
  • 2.2.3 Curcumin and gastrointestinal disorders
  • 2.2.4 Curcumin and hepatoprotective
  • 2.2.5 Curcumin and respiratory disorders
  • 2.2.6 Curcumin and cancer
  • 2.2.7 Curcumin and diabetes mellitus
  • 2.2.8 Curcumin and autoimmune diseases
  • 2.2.9 Curcumin as a chelating agent
  • 2.3 Conclusion
  • Conflict of interests
  • References
  • 3 Chemical structure and molecular targets of curcumin for cancer therapy
  • 3.1 Introduction
  • 3.2 Chemistry of curcumin
  • 3.3 Functionalities and synthesis of natural curcumin
  • 3.4 Curcumin revamped to super curcumin
  • 3.4.1 Curcumin-based pyrazole analogs
  • 3.4.2 Bioisosteric-based curcumin analogs
  • 3.4.3 Pyrimidine-based curcumin analogs
  • 3.4.4 Furochromone carbaldehyde-based curcumin analogs
  • 3.4.5 Bioconjugate-based curcumin analogs
  • 3.4.6 Electron-rich curcumin analogs
  • 3.4.7 Carbonyl analogs of curcumin
  • 3.4.8 Indole analogs of curcumin
  • 3.4.9 Ester and acid analogs of curcumin
  • 3.4.10 Coumarin analogs of curcumin
  • 3.4.11 Hybrid analogs of curcumin
  • 3.5 Curcumin as tumor suppressor and its molecular targets
  • 3.6 Curcumin for cancer therapy
  • 3.6.1 Breast cancer
  • 3.6.2 Prostate cancer
  • 3.6.3 Brain cancer
  • 3.6.4 Leukemia
  • 3.6.5 Lung cancer
  • 3.6.6 Lymphoma
  • 3.6.7 Multiple myeloma
  • 3.6.8 Liver cancer
  • 3.6.9 Gastric cancer
  • 3.6.10 Colorectal cancer
  • 3.6.11 Pancreatic cancer
  • 3.6.12 Hepatic cancer
  • 3.7 Conclusion and future perspective
  • Acknowledgment
  • References
  • 4 Structural features of curcumin and its effects on cancer-related signaling pathways
  • 4.1 Curcumin chemistry
  • 4.2 Changes in a structurally modified curcumin's anticancer activity
  • 4.3 Curcumin's function on CDK inhibitors and CDK/cyclin complexes
  • 4.4 P53 pathway and curcumin interaction
  • 4.5 Curcumin's targets in the cancer signaling pathway