Advanced drug delivery systems for colonic disorders /

Advanced Drug Delivery Systems for Colonic Disorders present the current state of the art methods for targeted drug delivery to the colon. These methods can prolong drug half-lives, improve bioavailability, optimize pharmacokinetics, and reduce medication dosing frequency.Chapters are written in a w...

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Bibliographic Details
Corporate Author:	ScienceDirect (Online service)
Other Authors:	Dureja, Harish
Format:	eBook
Language:	English
Published:	London : Academic Press, 2024.
Subjects:	Colon (Anatomy) > Diseases > Treatment. Drug delivery systems. Drug Delivery Systems Côlon > Maladies > Traitement. Systèmes d'administration de médicaments. Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Front Cover
Advanced Drug Delivery Systems for Colonic Disorders
Copyright Page
Contents
List of contributors
1 Introduction to colonic disorders
1.1 Introduction
1.1.1 Anatomy
1.1.2 Transport time
1.1.3 Circulatory network
1.1.4 Microvilli
1.1.5 Intestinal fluid
1.1.6 Microbial environment
1.2 Classification of colon disorders
1.3 Inflammatory bowel disease
1.3.1 Crohn's disease
1.3.2 Ulcerative colitis
1.4 Diverticulosis
1.5 Colon cancer
1.6 Formulation approaches for targeting colon
1.6.1 pH-dependent drug delivery systems
1.6.2 Polymer-based nano-/microparticles
1.6.3 Lipid-based formulations
1.6.4 Tablets and capsules
1.6.5 Enzyme-sensitive drug delivery systems
1.6.5.1 Polysaccharide-based systems
1.6.5.2 Phloral technology
1.6.6 Ligand/receptor-mediated drug delivery system
1.6.6.1 Antibodies
1.6.6.2 Folic acid
1.6.7 Magnetically driven drug delivery system
1.6.8 Rectal drug delivery
1.7 Conclusion
References
2 Cellular and molecular mechanisms involved in colonic disorders
2.1 Introduction
2.2 Molecular mechanisms involved in colonic disorders
2.2.1 Role of inflammatory cytokines in colonic disorders
2.2.2 Altered neurotransmitter signaling in colonic disorders
2.2.3 Role of eicosanoids
2.2.4 Role of nitric oxide
2.2.5 Oxidative stress in colonic disorders
2.2.6 Role of bidirectional neural-gut connection in Colonic disorders
2.2.7 Apoptosis in Colonic disorders
2.2.8 Role of neuroendocrine peptides in colonic disorders
2.2.9 Genetic mutations in colonic disorders
2.3 Conclusion
References
3 Current approaches for treatment of colonic disorder
3.1 Introduction
3.2 Different type of colonic disorder and their treatment
3.2.1 Diverticular disease.
3.2.1.1 Medical treatment of diverticular disease
3.2.1.1.1 5-ASA in diverticular disease
3.2.1.1.2 Probiotics in diverticular disease
3.2.1.1.3 Surgery
3.2.2 Inflammatory bowel disease
3.2.2.1 Current therapeutic
3.2.2.2 Antibiotics, prebiotics, and probiotics
3.2.2.3 Biologics
3.3 Alternative and complementary approaches
3.4 Neurokinin antagonists and &amp
Kappa
opioid agonists
3.4.1 Colorectal cancer
3.4.1.1 Medication and hormones regular
3.4.1.2 Preventive strategies
3.4.1.3 Primary prevention
3.4.1.4 Secondary prevention
3.4.1.5 Treatment strategies
3.4.1.6 Targeted therapy
3.4.1.7 Gene therapy
3.4.1.8 Immunotherapy
3.4.1.9 Monoclonal antibody therapy
3.4.1.10 Cancer vaccines
3.4.1.11 OncoVAX
3.4.1.12 Adoptive T-cell therapy
3.5 Ischemic colitis
3.6 Constipation
3.6.1 Osmotic laxatives
3.6.2 Prokinetic agents
3.6.3 Probiotics
3.7 Conclusion and future perspective
References
4 Polysaccharides based drug delivery systems for the treatment of colon diseases
4.1 Introduction
4.2 Types of polysaccharides
4.2.1 Chitosan
4.2.2 Alginate
4.2.3 Pectin
4.2.4 Guar gum
4.2.5 Dextran
4.2.6 Starch
4.2.7 Locust bean gum
4.2.8 Hyaluronic acid
4.2.9 Inulin
4.2.10 Cyclodextrins
4.2.11 Arabinoxylans
4.2.12 Chondroitin sulfate
4.3 Tempering in structural arrangement of polysaccharides
4.3.1 Physical interaction
4.3.2 Chemical interaction
4.4 Physicochemical properties of polysaccharides
4.5 Biotolerance properties
4.6 Development of theranostics
4.7 Polysaccharide-based devivery systems
4.7.1 Polysaccharide containing microbeads
4.7.2 Microspheres made of polysaccharide
4.7.3 Nanoparticles derived from polysaccharides
4.7.4 Nano-sized spheres of polysaccharide.
4.7.5 A nano gel based on polysaccharides
4.7.6 Polysaccharide-based quantum dots
4.7.7 Polysaccharide derived liposomes
4.7.8 Microcapsules developed from polysaccharides
4.8 Analyses of colon-specific carriers in vitro and in vivo
4.8.1 In vitro evaluation
4.8.2 In vivo evaluation
4.9 Conclusion
References
5 Synthetic polymers as biomaterials for the treatment of colon diseases
5.1 Introduction
5.2 Colon diseases
5.2.1 Inflammatory bowel diseases
5.2.1.1 Colorectal cancer
5.3 Colon delivery: physiology and biopharmaceutical considerations
5.4 Synthetic polymers as biomaterials for colon drug delivery system
5.4.1 pH-dependent polymers
5.4.2 Erodible or swellable or time-dependent polymers
5.4.2.1 Hydroxypropyl methylcellulose
5.4.2.2 Hydroxypropyl cellulose and hydroxyethyl cellulose
5.4.3 Water-insoluble polymers (ethyl cellulose)
5.4.4 Bacterially triggered polymers (pectin, chitosan, cyclodextrin)
5.4.4.1 Polysaccharide modification
5.4.4.1.1 Guar gum
5.4.4.1.2 Pectin
5.4.4.1.3 Chitosan
5.4.4.1.4 Dextran
5.4.5 Bioresorbable polymers
5.5 Industrial patents and marketed preparations
5.6 Conclusion
References
6 Mucoadhesive polymers as biomaterials for the treatment of colon disorders
6.1 Introduction
6.1.1 Mucoadhesion
6.1.1.1 Theories of mucoadhesion
6.1.1.1.1 Wetting theory
6.1.1.1.2 Adsorption theory
6.1.1.1.3 Diffusion theory
6.1.1.1.4 Fracture theory
6.1.1.1.5 Electronic theory
6.1.2 Mechanism of mucoadhesion
6.1.3 Factors affecting the mechanism of mucoadhesion
6.2 Mucoadhesive drug delivery systems
6.2.1 Characteristics of ideal mucoadhesive polymer
6.2.2 Classification of the mucoadhesive polymers
6.3 Mucoadhesive polymers in drug delivery system.
6.3.1 Mucoadhesive polymers in the treatment of colon disorders
6.3.1.1 Hydrophilic polymers
6.3.1.2 Hydrogels
6.3.1.3 Thiolated polymers
6.3.1.4 Lectin-based polymers
6.3.2 Delivery sites of mucoadhesive polymers
6.3.2.1 Buccal cavity
6.3.2.2 Vaginal and rectal lumen
6.3.2.3 Gastrointestinal tract
6.3.3 Commercial mucoadhesive drug delivery system
6.3.4 Advantages of mucoadhesive-based drug delivery system in the treatment of colon disorders
6.4 Recent advances in mucoadhesive polymers for colon disorders
6.4.1 Mucoadhesive microspheres
6.4.2 Mucoadhesive nanoparticles
6.4.3 Dual-drug-loaded mucoadhesive nanoparticles
6.4.4 Mucoadhesive chitosan-based nanoparticles
6.4.5 Naturally occurring biopolymers
6.4.5.1 Amino acid/protein-based mucoadhesive polymers
6.4.5.2 Snail-produced mucin proteins
6.4.5.3 Zwiterrionic polymeric nanoparticles as mucoadhesive agents
6.5 Limitations of mucoadhesive polymers-based drug delivery approaches for the treatment of colon disorders
6.6 Future perspectives
6.7 Conclusion
References
7 Colon-responsive oral drug delivery for combating colonic disorders
7.1 Introduction
7.2 Fundamentals of encapsulation technologies for oral delivery for colon diseases
7.3 Recent literature in colon-responsive drug delivery
7.3.1 pH-sensitive colon-responsive drug delivery
7.3.2 Prodrug
7.3.3 Time-dependent colon-responsive drug delivery
7.3.4 Nanotools for colon-responsive drug delivery
7.3.5 Other approaches for colon-responsive drug delivery
7.4 Conclusion
References
8 Colon-responsive targeted drug delivery for treating colonic disorder
8.1 Introduction
8.2 Physiology of the gastrointestinal tract
8.3 Physicochemical properties of drugs influencing CDDS.
8.4 Different approaches to colon-targeted drug delivery systems
8.4.1 Multistimuli systems for colonic drug delivery via the oral route
8.4.2 Superporous hydrogels as CDDS
8.4.3 pH-Dependent drug delivery systems
8.4.4 Lipid-based formulations
8.4.5 Bacterial enzymes-based drug delivery system
8.4.6 Polysaccharide-based systems
8.4.6.1 Polymeric micelles
8.4.7 Liposomes in colon-targeted drug delivery systems
8.4.8 Microspheres for controlled release of drug molecules
8.4.9 Magnetic nanoparticles for colon-targeted drug delivery systems
8.5 Challenges and conclusion
References
9 Advancement in targeted drug delivery systems in managing colonic disorders
9.1 Introduction
9.2 Colon-responsive targeted drug delivery approaches
9.2.1 Prodrug
9.2.2 pH-sensitive system
9.2.3 Bacterial-enzyme activated
9.2.3.1 Osmotically controlled
9.2.4 Coated tablets and capsules-based approaches
9.2.5 Nanotechnology-based targeting
9.2.6 Theranostic approach
9.2.7 Bioelectronic devices for colon targeting
9.2.8 Computer-assisted formulation design development for targeting colon
9.3 Conclusion
References
10 Nutraceuticals and phytoceuticals in the treatment of colon disorders
10.1 Introduction
10.2 Nutraceuticals as drug delivery systems for colonic disorders
10.2.1 Functional colonic disorders
10.2.2 Constipation
10.2.3 Irritable bowel syndrome
10.2.4 Functional dyspepsia
10.2.5 Gastroesophaegeal reflux disease
10.2.6 Various structural colonic disorders
10.2.7 Inflammatory bowel disease
10.2.8 Gastrointestinal cancer
10.2.9 Diverticular disease
10.2.10 Colorectal cancer
10.3 Plant materials as DDS for colonic disorders
10.3.1 Curcumin
10.3.2 Phenolic compounds
10.3.3 Halocynthiaxanthin
10.3.4 Glycyrrhizin glycyrrhizin
10.3.5 Saponins.