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Mineralizing vesicles : from biochemical and biophysical properties to their roles in physiology and disease /

Bibliographic Details
Corporate Author: ScienceDirect (Online service)
Other Authors: Bottini, Massimo, Ramos, Ana Paula
Format: eBook
Language:English
Published: [S.l.] : Academic Press, 2023.
Subjects:
Cell organelles.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Front Cover
  • MINERALIZING VESICLES
  • MINERALIZING VESICLES: From Biochemical and Biophysical Properties to Their Roles in Physiology and Disease
  • Copyright
  • Contents
  • List of contributors
  • Biographies
  • Preface
  • 1
  • General aspects of extracellular vesicles in bone formation and remodeling
  • 1. Introduction
  • 2. Communications between bone cells
  • 3. Extracellular vesicles
  • 4. Bone cell overview
  • 5. Bone marrow cells interacting with skeletal cells
  • 6. Extracellular vesicle trafficking in the bone microenvironment
  • 6.1 Extracellular vesicles and osteoblasts
  • 6.2 Extracellular vesicles and osteocytes
  • 6.3 Extracellular vesicles and osteoclasts
  • 7. Extracellular vesicles in fracture healing
  • 8. Extracellular vesicles and bone cancer
  • 9. Medical applications
  • 10. Conclusions
  • List of abbreviations
  • Acknowledgments
  • References
  • 2
  • Physiological biomineralization. The properties and role of matrix vesicles in skeletal and dental calcifications
  • 1. Introduction
  • 2. Biomineralization in teeth
  • 3. Biomineralization in bones
  • 4. Determinants of mineralization support the functions of matrix vesicles
  • 4.1 Matrix vesicles in dentin
  • 4.2 Matrix vesicles in cartilage
  • 4.3 Matrix vesicles in bones
  • 5. Conclusions
  • List of abbreviations
  • Acknowledgments
  • References
  • 3
  • Pathological biomineralization. Part I: Mineralizing extracellular vesicles in cardiovascular diseases
  • 1. Introduction
  • 2. Extracellular vesicles: origin and classification
  • 3. Extracellular vesicles related to cardiovascular diseases
  • 3.1 Extracellular vesicles released from vascular smooth muscle cells
  • 3.2 Extracellular vesicles released from M1 macrophages
  • 4. Extracellular vesicles: biomarkers of cardiovascular diseases
  • 4.1 Extracellular vesicles carrying RNAs
  • 4.2 Extracellular vesicles carrying proteins
  • 4.3 Extracellular vesicles carrying lipids and metabolites
  • 5. Extracellular vesicles as drug delivery vehicles in cardiovascular disease
  • 6. Conclusions
  • List of abbreviations
  • Acknowledgments
  • References
  • 4
  • Pathologic biomineralization: part II: mineralizing extracellular vesicles in osteoarthritis
  • 1. Introduction
  • 2. Historical perspective
  • 3. Characterization of ACVs
  • 3.1 ACV isolation procedures
  • 3.2 ACV mineralization assays
  • 3.3 ACV contents
  • 4. ACVs from osteoarthritis cartilage
  • 4.1 Differences in ACVs in osteoarthritis and normal cartilage
  • 4.2 Mechanisms of vesicle formation
  • 5. Factors affecting ACV mineralization
  • 5.1 Pi/PPi ratio
  • 5.2 Extracellular matrix composition
  • 5.3 Drugs
  • 6. Conclusions and future directions
  • List of abbreviations
  • References
  • 5
  • The biochemistry of mineralizing extracellular vesicles. Part I: The role of phosphatases
  • 1. Inorganic phosphate (Pi) and pyrophosphate (PPi): a physicochemical balance
  • 2. The molecules regulating the Pi/PPi ratio