Biomarkers in cancer detection and monitoring of therapeutics. Volume 2, Diagnostic and therapeutic applications /

Molecular Biomarkers in Cancer Detection and Monitoring of Therapeutics: Volume Two: Diagnostic and Therapeutic Applications discusses how molecular biomarkers are used to determine predisposition, facilitate detection, improve treatment and offer prevention guidelines for different cancers. It focu...

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Bibliographic Details
Corporate Author:	ScienceDirect (Online service)
Other Authors:	Sobti, Ranbir Chander (Editor), Watanabe, Masatoshi (Editor), Sobti, Aastha (Editor)
Format:	eBook
Language:	English
Published:	London, United Kingdom ; San Diego, CA : Academic Press, [2024]
Subjects:	Tumor markers > Diagnostic use. Tumor markers > Therapeutic use. Biomarkers, Tumor Neoplasms > diagnosis Neoplasms > prevention & control Neoplasms > therapy Marqueurs tumoraux > Utilisation diagnostique. Marqueurs tumoraux > Emploi en thérapeutique. Tumor markers > Diagnostic use Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Intro
Biomarkers in Cancer Detection and Monitoring of Therapeutics: Volume 2: Diagnostic and Therapeutic Applications
Copyright
Contents
Contributors
Preface
Chapter One: Oral squamous cell carcinoma
1. Oral cancer
2. Oral squamous cell carcinoma
3. Epidemiology
4. Etiology
Impact of tobacco products
Patterns and trends in tobacco use
Use of smokeless tobacco products
5. Precursor lesions
5.1. Genetically acquired potentially malignant disorders
5.2. Tobacco-induced potentially malignant disorders
5.3. Immune-mediated potentially malignant disorders
5.4. Genetically inherited potentially malignant disorders
6. Oral epithelial dysplasia
7. Pathogenesis
7.1. Autophagy
8. Cancer stem cells
9. Tumor microenvironment
10. Epithelial-mesenchymal transition
11. Metastasis
12. Oral bacteria in oral carcinogenesis
13. Clinical features
Salient features specific to subsite
14. Diagnosis
14.1. Adjunctive aids for early detection
Nano-diagnostics
Lab-on-chip/microfluidics
Liquid biopsy
Microarray technology
Next generation sequencing
Omics
Genomics
Transcriptomics
Proteomics
Metabolomics
Staging of oral squamous cell carcinoma
15. Histopathological features
16. Treatment
16.1. Surgical resection
Management of primary lesion
Management of neck nodes
16.2. Chemotherapy
Adjuvant chemotherapy
Adjuvant chemoradiotherapy
Primary chemoradiation
Induction chemotherapy
In the management of metastatic disease
16.3. Nanotechnology in carcinoma therapy
Chemoprevention using nanoparticles
16.4. Radiotherapy
16.5. Immunotherapy
Cytokines
Toll-like receptors
Immune checkpoint inhibitors
Immune checkpoint activators
16.6. Therapeutic markers
17. Prognosis
17.1. Clinical factors
17.2. Histopathological factors
17.3. Metastasis
References
Chapter Two: Genetic predisposition and pathophysiology of oral squamous cell carcinoma
1. Introduction
1.1. Microbial flora
1.2. Oral microbial flora
1.3. Oral microbial flora and cancer
1.4. Squamous cell carcinoma of the head and neck
2. Oral squamous cell carcinoma and glucose transporters
2.1. Human glucose transporters
2.2. Glucose transporters (GLUT 1) and its expression
3. Oral squamous cell carcinoma and methylated genes
3.1. Variation of methylated genes in cancer conditions
3.2. DNA methylation modifications and its implications
References
Chapter Three: Molecular biomarkers in gastric cancer
1. Introduction
2. RNF43
3. APC
4. ARID1A
5. ARID2
6. MSI
7. MALTA1-GLT1 fusion
8. TP53
9. RB1
10. ERBB2
11. C-MET
12. EGFR
13. PD-L1
14. Epstein-Barr virus
15. VEGF-A
16. CD44
17. E-cadherin
18. Matrix metalloproteinases (MMPs)
19. Conclusions