Hydrogels for tissue engineering and regenerative medicine : from fundamentals to applications /

Hydrogels for Tissue Engineering and Regenerative Medicine: From Fundaments to Applications provides the reader with a comprehensive, concise and thoroughly up-to-date resource on the different types of hydrogels in tissue engineering and regenerative medicine. The book is divided into three main se...

Full description

Bibliographic Details
Corporate Author:	ScienceDirect (Online service)
Other Authors:	Oliveira, Joaquim Miguel (Editor), Silva-Correia, Joana (Editor), Reis, Rui L. (Editor)
Format:	eBook
Language:	English
Published:	London : Academic Press, 2024.
Subjects:	Colloids > Therapeutic use. Tissue engineering. Tissue Engineering Génie tissulaire. Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Front Cover
Hydrogels for Tissue Engineering and Regenerative Medicine
Copyright Page
Contents
List of Contributors
Preface
1 Fundamentals, open issues and challenges
1 Fundamentals of hydrogels I-mechanical characterization
1.1 Introduction
1.2 Macroscale characterization of mechanical properties of hydrogels
1.3 Microscale and nanoscale indentation of hydrogels
1.4 Conclusions
Acknowledgments
Declaration of conflict of interest
References
2 Fundamentals of hydrogels II-architecture and biodegradability
2.1 Hydrogel architecture: structure and preparation
2.1.1 Natural and synthetic polymers
2.1.2 Hydrogels preparation
2.2 Hydrogel properties
2.2.1 Swelling properties
2.2.2 Gel formation mechanism
2.2.3 Mechanical properties
2.2.4 Mass transport
2.2.5 Biological properties
2.2.5.1 Biocompatibility
2.2.5.2 Biodegradability
2.3 Degradation mechanisms
2.4 Conclusions
References
3 Natural hydrogels: synthesis, composites, and prospects in wound management
3.1 Introduction
3.1.1 Wound care
3.1.2 Compromised wounds: major burden
3.1.3 Wounds
3.1.4 Nonhealing wounds
3.1.5 Factors contributing compromised wounds
3.2 Drug delivery systems
3.3 Hydrogels
3.3.1 Classification of hydrogels
3.3.2 Radiation processing of hydrogels
3.3.3 General methods employed for the preparation of hydrogels
3.3.3.1 Homopolymer hydrogel
3.3.3.2 Copolymeric hydrogel
3.3.3.3 Semiinterpenetrating networks
3.3.4 Interpenetrating networks
3.4 Natural polymers
3.4.1 Classification of natural polymers
3.4.1.1 Chitosan
3.4.1.2 Cellulose
3.4.1.3 Glucomannan
3.4.1.4 Agar
3.4.1.5 Starches
3.4.1.6 Pectin
3.4.1.7 Inulin
3.4.1.8 Rosin
3.4.1.9 Guar gum
3.4.1.10 Gum arabic
3.4.1.11 Tragacanth
3.4.1.12 Alginates.
3.4.1.13 Psyllium
3.4.1.14 Xanthan gum
3.4.2 General properties of natural polymers
3.4.2.1 Biodegradability
3.4.2.2 Biocompatibility and nontoxicity
3.4.2.3 Economical
3.4.2.4 Safe and devoid of side effects
3.4.2.5 Easy availability
3.5 Polymer-based systems for compromised wounds
3.6 Challenges in treatment of compromised wounds
3.7 Conclusion
Abbreviations
References
4 Elastin-like hydrogels as tissue regeneration scaffolds
4.1 Introduction
4.2 Chemically crosslinked elastin-like hydrogel
4.2.1 Tropoelastin-based hydrogels
4.2.2 Hydrogels of elastin-like polypeptides
4.3 Physically crosslinked elastin-like hydrogels
4.3.1 Elastin-like polypeptide and elastin-like polypeptide block copolymer-based hydrogels
4.3.2 Hydrogels from elastin-like polypeptides conjugates
4.4 Conclusions
References
5 In silico simulation for designing hydrogels
5.1 Introduction
5.2 Down to the atomistic scale (10−10m)
5.3 Zooming out to the nanoscale (10−9m)
5.4 The microscale (10−6m)
5.5 The millimeter scale (10−3m)
5.6 Machine learning and other open challenges
5.7 Cells and hydrogels
5.8 Conclusions
Acknowledgments
References
6 Hydrogel functionalization and crosslinking strategies for biomedical applications
6.1 Introduction
6.2 Natural hydrogels
6.2.1 Hyaluronic acid
6.2.2 Functionalization and modification of hyaluronic acid
6.2.3 Chitosan
6.2.3.1 Functionalization and modification of chitosan
6.2.4 Alginate
6.2.4.1 Functionalization and modification of alginate
6.2.4.2 Covalent crosslinking modifications of alginate's functional groups
6.2.5 Silk fibroin
6.2.5.1 Functionalization and modification of silk fibroin
6.2.6 Gellan gum
6.2.6.1 Functionalization and modification of gellan gum
6.2.7 Other biopolymers.
6.2.7.1 Cellulose
6.2.7.1.1 Chemical modifications of cellulose
6.2.7.2 Collagen
6.2.7.2.1 Chemical modifications of collagen
6.2.7.3 Peptides
6.2.7.4 Elastin
6.2.7.5 Agarose
6.2.7.5.1 Agarose hydrogels in biomedical applications
6.3 Synthetic hydrogel
6.3.1 Polyvinyl alcohol
6.3.2 Polyethylene glycol
6.3.3 Polyacrylamide hydrogels
6.4 Conclusion
References
7 Sterilization methods
7.1 Introduction
7.2 Conventional sterilization methods
7.2.1 Heat
7.2.2 Radiation
7.2.3 Gases and plasma
7.2.4 Liquids
7.3 Alternative sterilization methods
7.3.1 Ozone
7.3.2 Supercritical CO2
7.3.3 High hydrostatic pressure
7.3.4 Other techniques
7.4 Selection of the ideal sterilization method
7.5 Conclusions
References
8 Patent and regulatory issues of hydrogel for tissue engineering and regenerative medicine
8.1 Introduction
8.2 Concept of hydrogel in tissue engineering and regenerative medicine applications
8.3 Regulatory consideration of hydrogel-based tissue engineering and regenerative medicine products
8.4 Patents in hydrogel-based tissue regeneration
8.5 Patent search
8.6 Hydrogel in dressings
8.7 Hydrogel in bone repair
8.8 Peptide-based hydrogel
8.9 Two layered hydrogel composites
8.10 Cell-biomaterial-loaded hydrogel
8.11 Biological elastomer
8.11.1 Three-dimensional micropattern
8.12 Decellularized tissue-based hydrogel
8.13 Oxygen generating hydrogel
8.14 Keratin-based hydrogel
8.15 Summary
References
2 Types and processing
9 Ionic- and photo-crosslinked hydrogels
9.1 Introduction
9.2 Ionic/electrostatic-crosslinking
9.2.1 Biomaterials
9.3 Photo-crosslinking
9.3.1 Photo-initiators
9.3.2 Biomaterials
9.4 Conclusion and future trends
Acknowledgments
References.
10 Enzymatic crosslinked hydrogels
10.1 Introduction
10.2 Enzymatic polymer crosslinking reactions
10.3 Advanced crosslinking methodologies
10.4 Conclusion and outlook
Acknowledgements
References
11 Thermoresponsive hydrogel: a carrier for tissue engineering and regenerative medicine
11.1 Introduction
11.2 Hydrogel in the field of tissue engineering
11.3 Temperature-responsive hydrogel in the field of tissue engineering
11.4 Design criteria for thermoresponsive hydrogel in tissue engineering and regenerative medicine application
11.5 Application of thermoresponsive hydrogels in the field of tissue engineering
11.6 Neural tissue engineering
11.7 Cardiac tissue engineering
11.8 Bone and cartilage tissue engineering
11.9 Skin tissue engineering
11.10 Cornea tissue engineering
11.11 Tendon tissue engineering
11.12 Meniscus tissue engineering
11.13 Summary
Abbreviations
References
12 pH-responsive hydrogels: synthesis and physicochemical properties
12.1 Introduction
12.2 pH-responsive cationic hydrogels
12.2.1 Synthetic pH-responsive cationic hydrogels
12.2.2 Natural pH-responsive cationic hydrogels
12.3 pH-responsive acid hydrogels
12.3.1 Synthetic pH-responsive anionic hydrogels
12.3.2 Natural pH-responsive anionic hydrogels
12.4 Perspectives
References
13 Conductive hydrogels for tissue engineering applications
13.1 Introduction
13.2 Types and mechanism of conductive hydrogels
13.3 Conductive hydrogel based on conducting material/particles
13.3.1 Graphene
13.3.2 Carbon nanotubes
13.3.3 Metal nanoparticles
13.4 Conductive hydrogels based on conducting polymers
13.4.1 Polypyrrole
13.4.2 Polyaniline
13.4.3 Poly(3,4-ethylenedioxythiophene)
13.4.4 Polythiophenes
13.4.5 Poly(p-phenylenevinylene)
13.5 Conclusion.