Nucleic acids : a natural target for newly designed metal chelate based drugs /

Nucleic Acids: A Natural Target for Newly Designed Metal Chelate Based Drugs discusses how human diseases are becoming more costly to treat, along with updates on the resistance offered by disease-causing agents. The abundance of drugs in the market has provided great relief to patients, but side ef...

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Bibliographic Details
Corporate Author:	ScienceDirect (Online service)
Format:	eBook
Language:	English
Published:	London : Academic Press, 2023.
Subjects:	Nucleic acids. Nucleic acids Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Front Cover
NUCLEIC ACIDS
NUCLEIC ACIDSA NATURAL TARGET FOR NEWLY DESIGNED METAL CHELATE BASED DRUGS
Copyright
Contents
List of contributors
Abbreviations
Introduction
1
Zinc complexes: Their interaction with nucleic acids and other biomolecular targets
1. Chemistry of zinc
2. Interaction of synthesized zinc complexes with nucleic acids
3. Methods of analysis
3.1 Electronic spectroscopy
3.2 Fluorescence spectrometry
3.3 Circular dichroism
3.4 Electrochemical method
3.5 Viscometric studies
4. Interaction of zinc complexes with biomolecules
4.1 Interaction studies of zinc complexes with DNA
4.2 RNA as a drug target
4.3 Interaction of zinc complexes with albumin proteins
4.4 Interaction studies of zinc complexes with topoisomerase enzymes
5. Conclusion
References
2
Ruthenium complexes: An insight into their interactions with nucleic acids and biomolecules
1. Chemistry of ruthenium
2. Methods of synthesis
2.1 Organometallic Ru(II)-arene complexes
2.2 Homoleptic Ru(II) complexes of the type [Ru(L)3]2+
2.3 Heteroleptic Ru(II) complexes of the type [Ru(L1) (L2)2]2+
2.4 Dinuclear Ru(II) complexes
3. Methods of analysis
3.1 Mass spectroscopy
3.2 NMR spectroscopy
3.3 X-ray crystallography
3.4 Absorption spectroscopic techniques
3.5 Fluorescence spectroscopy
3.6 Molecular docking
4. Uses of metal complexes
4.1 Ruthenium complexes as DNA interacting agents
4.2 Ruthenium complexes as RNA interacting agents
4.3 Ruthenium complexes as other biomolecule interacting agents
4.3.1 DNA topoisomerases
4.3.2 Serum proteins (HSA/BSA)
5. Limitations
6. Future prospects
7. Conclusions
References
3
Nucleic acid interactions of copper complexes
1. Chemistry of copper
2. Methods of synthesis.
2.1 Cu(I)/(II)-Schiff base complexes
2.2 Mononuclear Cu complexes
2.3 Dinuclear Cu complexes
3. Methods of analysis
3.1 EPR spectroscopy
3.2 X-ray crystallography
3.3 Molecular docking studies
3.4 Absorption spectroscopy
3.5 Fluorescence spectroscopy
4. Uses of metal complexes
4.1 DNA-interacting copper complexes
4.2 RNA interacting copper complexes
4.3 Interaction with other biomolecules
5. Limitations
6. Future prospects
7. Conclusions
References
4
Recent advances in iron complexes and their interaction with nucleic acids
1. Chemistry of iron
2. Methods of synthesis
2.1 Mononuclear Fe complexes
2.2 Dinuclear Fe complexes
2.3 Tetranuclear Fe complexes
2.4 Heterobimetallic Fe complexes
2.5 Schiff base Fe complexes
3. Methods of analysis
3.1 Absorption spectroscopy
3.2 Fluorescence spectroscopy
3.3 Circular dichorism spectroscopy
3.4 Molecular docking studies
4. Uses of metal complexes
4.1 DNA interacting iron complexes
4.2 RNA-interacting iron complexes
4.3 Other biomolecule-interacting iron complexes
5. Limitations
6. Future prospects
7. Conclusions
References
5
Manganese complexes: Their interaction studies with nucleic acids and biomolecules
1. Chemistry of manganese
2. Methods of synthesis
2.1 Synthesis of neutral di- and trinuclear Mn2+ complexes
2.2 Synthesis of manganese corroles
2.3 Manganese halide complexes
2.4 Synthesis of manganese carbonyl and manganese carbonyl halide complexes
2.5 Synthesis of mixed-Mn complexes
3. Methods of analysis
3.1 Electronic absorption titrations
3.2 Fluorescence emission spectroscopy
3.3 Electrospray ionization-mass spectrometry and tandem mass spectrometry
3.4 Viscosity measurements
3.5 Circular dichroism spectroscopy
3.6 Cyclic voltammetry.
3.7 Melting temperature studies
3.8 NMR spectroscopy
3.9 X-ray crystallography
3.10 Molecular docking
4. Applications of manganese complexes
4.1 Manganese complexes as DNA-interacting agents
4.2 Manganese complexes as RNA-interacting agents
4.3 Manganese complexes as other biomolecule-interacting agents
4.3.1 DNA topoisomerases (Topo I/Topo II)
4.3.2 Serum proteins (HSA/BSA)
4.3.3 RNase
4.3.4 Lipids
4.3.5 Peptides
5. Limitations
6. Future prospects
7. Conclusion
References
Index
Back Cover.