Privileged scaffolds in drug discovery /

Privileged Scaffolds in Drug Discovery is the most complete and up-to-date work in the area. Covering a wide range of privileged structures, it is a perfect reference for scientists involved in targeted drug development. The editors recruited experts from several prestigious Chinese institutions to...

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Bibliographic Details
Corporate Author:	ScienceDirect (Online service)
Other Authors:	Yu, Bin, Li, Ning, Fu, Caiyun
Format:	eBook
Language:	English
Published:	[S.l.] : Academic Press, 2023.
Subjects:	Drug development. Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Front Cover
Privileged Scaffolds in Drug Discovery
Privileged Scaffolds in Drug Discovery
Copyright
Contents
List of contributors
Preface
Introduction
1
Thiazole, a privileged scaffold in drug discovery
1. Introduction
2. Thiazole derivatives as therapeutic agents
2.1 Second-generation cephalosporin antibiotics containing thiazole moiety
2.2 Third-generation cephalosporin antibiotics containing thiazole substituent
2.3 Aminothiazole-containing third-generation cephalosporins for veterinary use
2.4 Cephalosporin antibiotics with aminothiazole group used in prodrug forms
2.5 Fourth-generation cephalosporin antibiotics containing thiazole nucleus
2.6 Fifth-generation cephalosporin antibiotics and monobactams containing aminothiazole group
2.7 Thiazole-containing natural products as antimicrobial agents
2.8 Antifungal and antiprotozoal agents containing thiazole nucleus
2.9 Thiazole derivatives as antifungal and antituberculosis agents
2.10 Thiazole derivatives as anticancer drugs
2.11 Thiazole-containing antiproliferative agents
2.12 Thiazole-containing drugs to treat inflammatory and blood-borne diseases
2.13 Thiazole derivative to treat urologic and neurologic disorders
2.14 Miscellaneous drugs and useful compounds containing thiazole nucleus
2.15 Thiazole-containing essential bioactive compounds
3. Conclusions
Acknowledgments
References
2
Chalcones: Diverse biological activities and structure-activity relationships
1. Background
2. Biological activities of chalcone derivatives
2.1 Anticancer activity
2.1.1 Chalcone-azole hybrids
2.1.2 Chalcone-furan/thiophene hybrids
2.1.3 Chalcone-indole hybrids
2.1.4 Chalcone-pyridine hybrids
2.2 Antiinflammatory and antioxidant activities
2.2.1 Simple chalcone compounds
2.2.2 Licochalcone B.
2.5 1,2,3-Triazole as bioisostere for other groups
3. Biological significance
3.1 Anticancer activity
3.2 Antimicrobial activity
3.3 Other activities
4. Conclusions and prospects
Acknowledgments
References
7
Oxazolidinone scaffolds in drug discovery and development
1. Introduction
2. Launched oxazolidinone antibacterial drugs
2.1 Linezolid
2.2 Tedizolid
3. Modification of linezolid-based oxazolidinone medications
3.1 Morpholine ring/C-5 position modifications
3.1.1 Morpholine ring modification
3.1.2 C-5 modification
3.2 Concurrent alterations to C-5 site and morpholine ring
3.2.1 Oxazolidinone-biphenyl chalcone hybrid derivative compounds
3.2.2 Derivatives of spiropyrimidinetrione oxazolidinone
3.2.3 [1,2,5]Triazepane or [1,2,5]oxadiazepane oxazolidinone compounds
3.2.4 C-Ring heteroaromatic antibacterial oxazolidinones
3.2.5 N-Substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinone derivatives
3.2.6 Replaced ligustrazine C-ring oxazolidinone antibiotics
3.2.7 Silicon-containing oxazolidinone antibiotics
3.2.8 Antibiotic oxazolidinones containing dihydropyridone C-ring unit
3.3 Derivatives of tricyclic fused oxazolidinones
3.3.1 (Pyridin-3-yl)benzo[1,4]oxazinyl-oxazolidinones
3.3.2 (Tetrahydropyridine-4-yl)benzo[1,4]oxazinyl-oxazolidinones
3.3.3 Thiomorpholine benzo[1,4]oxazinyl-oxazolidinones
3.3.4 Benzo[1,3]oxazinyl-oxazolidinones
4. Other novel oxazolidinone derivatives
4.1 Azetidinone moieties
4.2 Motifs of amide, sulfonamide, and thiourea
4.3 Chloroquinoline moieties
4.4 Thiazole hybrid moieties
4.5 Oxazolidinone derivative-based UDP-3-O-acyl-N-acetylglucosamine deacetylase inhibitor
4.6 3-Amino-2-oxazolidinone derivatives
5. Effects of oxazolidinone derivatives on other diseases
6. Summary and perspective
References.