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Ionizing Radiation and the Immune Response - Part B.

This volume, part of the International Review of Cell and Molecular Biology series, delves into the intersection of ionizing radiation and the immune response. It explores the dual impact of radiation therapy on immune responses, focusing on radio-induced lymphopenia and the integration of radiother...

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Bibliographic Details
Main Author: Galluzzi, Lorenzo
Corporate Author: ScienceDirect (Online service)
Other Authors: Mirjolet, Celine
Format: eBook
Language:English
Published: San Diego : Elsevier Science & Technology, 2023.
Series:Issn Series.
Subjects:
Radiotherapy.
Immune response.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Front Cover
  • Ionizing Radiation and the Immune Response
  • Part B
  • Copyright
  • Contents
  • Contributors
  • Dual impact of radiation therapy on tumor-targeting immune responses
  • Acknowledgments
  • Competing interests
  • References
  • Chapter One: Radio-induced lymphopenia in the era of anti-cancer immunotherapy
  • 1. Introduction
  • 2. Radio-induced lymphopenia (RIL)
  • 2.1. Clinical definition
  • 2.2. Incidence and therapeutic implications of RIL
  • 2.3. Prognostic factors for RIL
  • 3. Dynamics of RIL
  • 3.1. Depletion phase
  • 3.2. Remission phase
  • 4. RIL in the era of immunotherapies
  • 4.1. Lymphopenia as a poor prognostic factor of outcome in combined radiotherapy/immunotherapy treatments
  • 4.2. Synergistic mechanisms
  • 4.3. Radiotherapy and immunotherapy combination in clinics
  • 5. How to implement efficient lymphocyte sparing radiotherapy?
  • 6. Conclusion
  • Acknowledgments
  • References
  • Chapter Two: Combining radiotherapy and NK cell-based therapies: The time has come
  • 1. Introduction
  • 2. Radiation therapy can improve the NK cell-mediated anti-tumor response
  • 2.1. NK expansion and activation depending on dose and fractionation