Personal care product and human health /

Personal Care Products and Human Health provides background, historical context and the latest research results on personal care products (PCPs) and their impact on human health and the environment. Sections provide an overview of the functions and mechanisms of action of components of personal care...

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Bibliographic Details
Corporate Author:	ScienceDirect (Online service)
Other Authors:	Carbre, Philippa D.
Format:	eBook
Language:	English
Published:	London ; San Diego, CA : Academic Press, an imprint of Elsevier, [2023]
Subjects:	Hygiene products > Environmental aspects. Environmental toxicology. Pollutants. Cosmetics > adverse effects Environmental Pollutants Ecotoxicology Produits d'hygiène > Aspect de l'environnement. Écotoxicologie. Polluants. pollutants. Environmental toxicology Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Front Cover
PERSONAL CARE PRODUCTS AND HUMAN HEALTH
PERSONAL CARE PRODUCTS AND HUMAN HEALTH
Copyright
Contents
Contributors
Preface
1
Introduction to the constituents of PCPs and their functions
1
Introduction to personal care products
1.1 Introduction
1.2 Historical background
1.3 Sites of exposure of the human body to personal care products
1.3.1 Human skin
1.3.2 Human hair
1.3.3 Human respiratory system
1.3.4 Human oral cavity
1.3.5 Human female genitalia
1.4 Functional components of personal care products
1.4.1 Cleansers, surfactants, and abrasives
1.4.2 Conditioning and moisturizing agents
1.4.3 Solvents, emulsifiers, spreading agents, penetration enhancers, and plasticizers
1.4.4 Thickening and stiffening agents
1.4.5 Preservatives
1.4.6 Deodorants
1.4.7 Antiperspirant
1.4.8 Dehydrators
1.4.9 UV filters
1.4.10 Fragrance and fragrance fixers
1.4.11 Coloring agents
1.4.12 Biocides
1.5 Cosmeceuticals
1.6 Age- and gender-targeted products
1.7 Product format and packaging
1.8 Benefits, adverse effects, and arising concerns
1.9 Concluding comments
References
2
Overview of constituent compounds with concerns for adverse effects on human health
2.1 Introduction
2.2 Widely used constituent chemicals with arising human health concerns
2.2.1 Formaldehyde
2.2.2 Parabens
2.2.3 Triclosan
2.2.4 Phthalates
2.2.5 Bisphenols
2.2.6 UV filters
2.2.7 Fragrance and fragrance fixers
2.2.8 Aluminum salts
2.2.9 Cyclic volatile methylsiloxanes
2.2.10 Coal tar
2.2.11 Talcum powder
2.2.12 Dyes and coloring agents
2.2.13 Acrylates
2.2.14 Heavy metals
2.3 Nanomaterials
2.4 Natural versus synthetic compounds
2.5 Long-term low-dose mixtures
2.6 Early life exposures
2.7 Concluding comments.
7.8 Cyclic volatile methylsiloxanes
7.9 Concluding comments
References
3
Human health concerns
8
Contact dermatitis
8.1 Introduction
8.2 Global burden and increasing prevalence of PCP-related contact dermatitis
8.3 Anatomical sites of PCP-related contact dermatitis
8.4 Causative PCP components
8.4.1 Fragrance
8.4.2 Preservatives
8.4.3 p-substances
8.4.4 Polypropylene glycol and lanolin
8.4.5 Sunscreens and photocontact allergens
8.5 Concluding comments
References
9
Respiratory irritation and sensitization
9.1 Introduction
9.2 The respiratory tract as a target for inhaled ingredients of personal care products
9.3 Components of personal care products as pollutants of indoor air
9.4 Occupational asthma in beauty salon workers
9.5 Fragrance and asthma
9.6 Talcum powder
9.7 Nanoparticles
9.8 Early life exposures and adult lung function
9.9 Concluding comments
References
10
Endocrine disruption
10.1 Introduction: What are endocrine-disrupting chemicals and where are they found in personal care products?
10.2 Evidence that endocrine-disrupting chemicals are absorbed from dermal application of personal care products
10.3 Evidence that chemical constituents of personal care products possess endocrine-disrupting properties
10.3.1 Disruption of estrogen receptor-mediated mechanisms
10.3.2 Disruption of other steroid receptors
10.3.3 Disruption of thyroid hormone receptor-mediated mechanisms
10.3.4 Disruption of peroxisome proliferator-activated receptor mechanisms
10.3.5 Endocrine disruption through the aryl hydrocarbon receptor
10.3.6 Endocrine disruption through mixtures of chemicals
10.3.7 Endocrine disruption from long-term exposures
10.3.8 Nonmonotonic dose responses of endocrine disruptors.
10.3.9 Tissue-specific effects of endocrine disruption
10.4 Evidence that endocrine-disrupting chemicals contained in personal care products can affect human health
10.4.1 Direct evidence for human endocrine disruption following topical exposure to hormonally active compounds
10.4.2 Evidence that increased tissue levels of endocrine-disrupting chemicals originating from personal care products correlate w ...
10.4.2.1 Male reproductive health
10.4.2.2 Female reproductive health
10.5 Concluding comments
References
11
Early life exposure and developmental consequences
11.1 Introduction
11.2 Evidence for placental transfer of chemicals in personal care products
11.3 Evidence for transfer of chemicals in personal care products during breast feeding
11.4 Early life exposures and disruption of endocrine-regulated developmental pathways
11.4.1 Male reproductive health
11.4.2 Female reproductive health
11.4.3 Neurodevelopment disorders
11.4.4 Obesity
11.4.5 Epigenetic alterations in utero and transgenerational transmission
11.5 Early life exposures and susceptibility to dermatitis
11.6 Early life exposures and susceptibility to respiratory disease
11.7 Early life exposures and susceptibility to cancer development
11.8 Concluding comments
References
12
Development of cancer
12.1 Introduction
12.2 Chemical ingredients in personal care products and the hallmarks of cancer
12.3 Individual susceptibility and lifestyle choices
12.4 Lifestyle choices and the tumor microenvironment
12.5 Personal care products and breast cancer
12.5.1 Endocrine-disrupting chemicals and breast cancer
12.5.2 The case for a link between underarm cosmetics and breast cancer
12.5.3 Chemical ingredients and the hallmarks of breast cancer
12.5.3.1 Sustained proliferation.
12.5.3.2 Resistance to cell death
12.5.3.3 Evasion of growth suppressors
12.5.3.4 Replicative immortality
12.5.3.5 Invasion and metastasis
12.5.3.6 Induction of angiogenesis
12.5.3.7 Avoidance of immune destruction
12.5.3.8 Deregulation of cell metabolism
12.5.3.9 Genome instability and mutation
12.5.3.10 Tumor-promoting inflammation
12.5.4 Antiperspirants and breast cysts
12.6 Personal care products and cancers in other endocrine-sensitive tissues
12.7 Personal care products and endocrine therapy of cancer
12.8 Talcum powder and ovarian cancer
12.9 Sun care products and skin cancer
12.10 Concluding comments
References
13
Aluminum and its carcinogenic traits
13.1 Introduction
13.2 Carcinogens and carcinogenic metals
13.3 Aluminum
13.3.1 Generalities
13.3.2 Aluminum toxicity
13.3.3 Aluminum as a putative carcinogen
13.3.3.1 Epidemiological studies in breast cancer
13.3.3.2 Experimental data
13.3.3.2.1 Aluminum transforms mammary epithelial cells in vitro
13.3.3.2.2 Mammary epithelial cells transformed by aluminum in vitro form tumors and metastasis in vivo
13.3.3.2.3 Mechanisms of aluminum-induced cellular transformation
13.4 Conclusions
References
4
Regulatory considerations
14
Regulatory considerations and public education
14.1 Introduction
14.2 How is regulation brought about in different countries?
14.3 Challenges for risk assessment of personal care products
14.3.1 Advantages and disadvantages of different types of evidence
14.3.2 Importance of tissue-specific risk assessment
14.3.3 Special considerations for endocrine-disrupting chemicals
14.3.4 Genotoxicity
14.3.5 Nanomaterials
14.3.6 Cosmeceuticals
14.3.7 Long-term low-dose mixtures
14.4 Role of nongovernmental organizations and the mass media.