Sweet biochemistry : remembering structures, cycles and pathways by mnemonics /
"Sweet Biochemistry: Remembering Structures, Cycles, and Pathways by Mnemonics, Second Edition makes biochemistry lively, interesting and memorable by connecting objects, images and stories to biochemistry concepts. Here, Dr. Asha Kumari has converted cycles and difficult pathways into very sim...
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| Format: | eBook |
| Language: | English |
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London, United Kingdom ; San Diego, CA, United States :
Academic Press, an imprint of Elsevier,
[2023]
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| Edition: | Second edition. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Front Cover
- Sweet Biochemistry
- Copyright Page
- Dedication
- Contents
- List of figures
- List of tables
- Preface
- Acknowledgements
- 1 Glycolysis
- Microview
- Importance of glucose phosphorylation
- Role of magnesium for kinases
- Critical isomerisation to fructose
- Second phosphorylation
- Reason of DHAP conversion to Gly-3-P?
- Conversion of Gly-3-P to 1,3-bisphosphoglycerate
- Reaction of phosphoglycerate kinase: the heroic step
- 3-PG isomerises to 2-PG: the role
- Importance of enolase reaction
- 2 Citric acid cycle
- Quick view of pathway
- Reactions in detail
- Do you want to know the purpose of acetyl-CoA formation?
- Role of citrate's isomerisation to isocitrate
- Action of isocitrate dehydrogenase enzyme: first oxidative decarboxylation
- Second oxidative decarboxylation and adddition of CoA
- CoA removal from succinyl-CoA coupled with GTP formation
- A unique dehydrogenation of succinate to fumarate using FAD
- Fumarate to malate: a stereospecific hydration
- Malate dehydrogenation regenerates oxaloacetate, the substrate of first step
- 3 Electron transport chain
- Microview
- The special electron transporters: NADH and FADH2
- Ubiquinone or coenzyme Q
- Complexes and electron flow
- Complex I
- Complex II
- Complex III
- Complex IV
- The story of electron transport chain
- What relates to electron transport chain in the story?
- 4 Beta oxidation of fatty acids
- Importance of beta oxidation of fatty acids
- Carnitine: prominent molecule of beta oxidation
- 5 Fatty acid biosynthesis
- Traditional recap
- Microview
- Acetyl-CoA carboxylase
- Fatty acid synthase
- Relation of beta oxidation and synthesis of fatty acids synthesis
- 6 Cholesterol structure
- Role of cholesterol
- Lipid rafts and cholesterol
- What relates to cholesterol in honeycomb house?.
- 7 Cholesterol synthesis
- Traditional recap
- Microview
- First enzyme thiolase
- 3-Hydroxy-3-methylglutaryl-CoA synthase
- 3-Hydroxy-3-methylglutaryl-CoA reductase
- Story of queen bee's honeycomb house
- 8 Haem synthesis
- Rate-limiting step of haem synthesis: aminolevulinic acid formation
- Regulation of aminolevulinic acid synthase
- 9 Porphyrias
- Traditional recap
- Manifestations of porphyria
- Microview
- Why photosensitivity and neuropsychiatric symptoms are observed in porphyrias?
- Neuropsychiatric features
- 10 Urea cycle
- Carbamoyl phosphate synthetase 1: an unique enzyme
- Are there other modulators also for carbamoyl phosphate synthetase 1?
- 11 Urea cycle disorders
- Why ammonia is so toxic to brain?
- 12 Glycogen storage disorders
- Glycogen storage diseases
- Mechanisms for features of glycogen storage disorders
- Story mnemonic of glycogen storage disorders
- 13 Mucopolysaccharidoses
- Hurler disease
- Scheie syndrome: Mucopolysaccharidoses I
- Hunter syndrome: Mucopolysaccharidoses II
- Sanfilippo syndrome: Mucopolysaccharidoses III
- Morquio syndrome: Mucopolysaccharidoses IV
- Maroteaux-Lamy syndrome: Mucopolysaccharidoses VI
- Sly syndrome: Mucopolysaccharidoses VII
- 14 Lipid storage disorders/sphingolipidoses
- Tay-Sach's disease and Sandoff's disease
- Gaucher disease
- Niemann-Pick disease
- Farber's disease
- Fabry's disease
- Metachromatic leukodystrophy
- 15 Ceramide structure and derivatives
- What are ceramides doing in our body
- 16 Prostaglandin synthesis
- Biological actions of prostaglandins
- Cyclooxygenase is the controller of rate-limiting step
- 17 Purine structure
- Chemical structure
- Examples of Interesting purines
- 18 Purine synthesis de novo
- A brief view of reactions.
- Amido phosphoribosyl transferase (Atase)
- rate-limiting enzyme with a unique ammonia channel
- Interesting regulation of purines
- 19 Pyrimidine structure-2
- Uracil
- Thymine
- Cytosine
- 20 Pyrimidine de novo synthesis
- 21 DNA structure and DNA replication
- Alternative DNA structures
- Brief summary of steps of DNA replication
- 22 Differences in eukaryotic and prokaryotic replication
- 23 Transcription
- Steps of transcription
- 24 Translation
- 25 Inhibitors of translation
- Antibiotics and the mechanism of action
- Toxins that disturb protein synthesis
- Lectins
- 26 Operon
- The lac Operon
- 27 Various types of RNA
- Messenger RNA
- Small-nuclear RNA
- MicroRNA
- Small-interfering RNA
- Ribozyme
- 28 Antibody
- 29 Class switching
- When is class switching required?
- Mechanism of class switching
- 30 Antigen
- Hapten
- Superantigens
- Neoantigens
- Autoantigen
- Adjuvants
- 31 Major histocompatibility complex
- The categorisation of human leucocyte antigen forms three classes I, II and III
- 32 Vaccines
- Whole pathogen vaccines
- Subunit vaccine
- Recombinant protein vaccine
- Toxoid vaccine
- Conjugate vaccine
- Virus-like particles
- Outer membrane vesicle vaccines
- Nucleic acid vaccines
- Viral-vectored vaccines
- Exercises
- Further reading
- Index
- Back Cover.