Treatment landscape of targeted therapies in oncology : challenges and opportunities /
Treatment Landscape of Targeted Therapies in Oncology: Challenges and Opportunities provides up-to-date knowledge on antitumor-targeted therapies and immunotherapy. The book's chapters are written by researchers dynamically working/focusing on cancer treatment. The content is designed to help t...
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| Other Authors: | , |
| Format: | eBook |
| Language: | English |
| Published: |
London :
Academic Press,
[2023]
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| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Intro
- Title page
- Table of Contents
- Copyright
- List of contributors
- Preface
- Chapter 1. Biology of cancer: current insights and perspectives
- Abstract
- Introduction
- A perspective on cancer cell
- Epidemiology of cancer
- Clinical features and diagnosis
- Current and emerging treatment strategies
- Modern challenges in cancer therapy
- Emerging/advanced treatment strategies
- Conclusion and future perspectives
- References
- Chapter 2. Evolution of targeted therapies in cancer: opportunities and challenges
- Abstract
- Introduction
- Types of cancer
- Lung cancer
- Breast cancer
- Colorectal cancer
- Brain cancer
- Blood cancer
- Skin cancer
- Cervical cancer
- Targeted therapies in cancer
- Monoclonal antibodies
- Small molecule inhibitors
- Targeted immunotherapy
- Nanomaterials in cancer therapy
- Opportunities and challenges of targeted cancer therapy
- Conclusions
- Acknowledgments
- Conflict of interest
- Glossary words
- Essay type questions
- References
- Chapter 3. Clinical implementation of biomarkers and signaling pathway as novel targeted therapeutics in breast cancer
- Abstract
- Background
- Factors affecting breast cancer
- Classification of breast cancer
- Biomarkers in breast cancer: diagnostic to targeted therapy
- Targeting molecular signaling pathways
- HER2-positive targeted therapies
- HER2-negative targeted therapies
- Targeted therapy as emerging treatment options
- Conclusion and future perspective
- References
- Chapter 4. Targeted therapies in advanced lung cancerâ€"current landscapes and future projects
- Abstract
- Introduction
- What are targeted therapies
- Large molecule inhibitors
- Immunotherapy
- Monoclonal antibodies
- Small molecule inhibitors and their targets
- Conclusion and future perspectives
- Acknowledgment
- References.
- Chapter 5. Targeted therapies: emerging biomarkers in advanced melanoma
- Abstract
- Introduction
- Biomarkers in melanoma (prognostic and predictive)
- Malignant melanoma classification, diagnosis and treatment
- Nanotechnology: mechanisms and nanoparticles in melanoma therapies
- Nanosystems for improved targeted therapies in melanoma
- Conclusion
- References
- Chapter 6. Targeting immune checkpoints for cancer therapy
- Abstract
- Introduction
- Immune checkpoints
- Cytotoxic T-lymphocyte-associated antigen-4 signaling pathway: a promising therapeutic target in cancer
- Anti-PD-1/PDL-1 therapy
- Targeting mammalian target of rapamycin pathway for cancer therapy
- Vascular endothelial growth factor pathway in cancer therapy
- Targeting PI3k/Akt pathway
- Targeting mitogen-activated protein kinases network for cancer prevention
- Inhibition of cyclin-dependent kinases for cancer therapy
- Inhibiting epidermal growth factor receptor and human epidermal growth factor receptor 2 for cancer therapy
- Conclusion
- References
- Chapter 7. Glioblastoma targeted therapies: updated approaches from recent biological insights
- Abstract
- Abbreviations
- Introduction
- Various therapies for glioblastoma multiforme
- Conclusion
- References
- Chapter 8. Current trends and future prospects of molecular targeted therapy in head and neck squamous carcinoma
- Abstract
- Abbreviations
- Introduction
- Epidemiology
- Symptoms and pathophysiology
- Diagnosis and prevention
- Therapeutic strategies
- Existing therapies
- Future prospects
- Summary
- References
- Chapter 9. Targeted therapy and drug resistance in gastric and pancreatic cancer
- Abstract
- Targeted therapy and drug resistance in gastric cancer
- Targeted therapy and drug resistance in pancreatic cancer
- References.
- Chapter 10. Colorectal cancer heterogeneity and targeted therapy: clinical implications, challenges, and solutions for treatment resistance
- Abstract
- Introduction
- Molecular biology in metastatic colorectal cancer
- Systemic therapy in metastatic colorectal cancer
- Chemotherapy backbone for metastatic colorectal cancer
- Targeted therapy in first-line setting metastatic colorectal cancer
- Anti-VEGF: bevacizumab
- Antiepidermal growth factor receptor: cetuximab, panitumumab
- Immunotherapy
- BRAF-mutated
- KRAS-G12C-mutation in mCRC
- Elderly/frail patients
- Treatment alternatives after first-line
- Anti-VEGF
- Antiepidermal growth factor receptor
- Anti-BRAF+antiepidermal growth factor receptor
- Treatment alternatives in later lines
- Tyrosine kinase inhibitors
- Thymidine-based nucleoside analogs
- Immunotherapy
- Human epidermal growth factor receptor r2-directed therapy
- Rare actionable fusion proteins
- Local ablative therapy
- Conclusion
- References
- Chapter 11. Endometrial cancer: molecular markers and management of advanced-stage disease
- Abstract
- Introduction
- Type 1 versus type 2
- Classification of endometrial cancer on molecular basis
- Molecular markers of endometrial cancer
- Management of endometrial cancer
- Risk factors for endometrial cancer
- Conclusion
- Acknowledgments
- Statements and declaration
- Glossary items
- Essay-type questions
- References
- Index.