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Advanced and modern approaches for drug delivery /

"Advanced and Modern Approaches for Drug Delivery explores novel approaches currently used for drug delivery, including the must up-to-date techniques and technology. The approaches discussed allow pharmaceutical scientists to design effective drug delivery systems or devices for the management...

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Bibliographic Details
Corporate Author: ScienceDirect (Online service)
Other Authors: Kayak, Amit Kumar
Format: eBook
Language:English
Published: [S.l.] : Academic Press, 2023.
Subjects:
Drug delivery systems.
Drug Delivery Systems
Systèmes d'administration de médicaments.
Drug delivery systems
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Front Cover
  • Advanced and Modern Approaches for Drug Delivery
  • Advanced and Modern Approaches for Drug Delivery
  • Copyright
  • Contents
  • Contributors
  • 1
  • Novel drug delivery system
  • 1. Introduction
  • 1.1 Advantages of NDDS
  • 2. Novel drug delivery system
  • 2.1 Liposomes
  • 2.1.1 Composition of liposomes
  • 2.1.2 Classification of liposomes
  • 2.1.3 Advance and a recent update on the liposomes
  • 2.1.3.1 Conventional liposomes comprising a phospholipid
  • 2.1.3.2 PEGylated/stealth liposomes
  • 2.1.3.3 Ligand-targeted liposomes
  • 2.1.3.4 Multifunctional liposomes
  • 2.1.4 Liposomes-based marketed products
  • 2.2 Transfersomes
  • 2.2.1 Merit/demerit of transferesomes
  • 2.3 Ethosomes
  • 2.3.1 Advantages of ethosomes
  • 2.4 Nanoparticles
  • 2.4.1 Advantages of nanoparticles
  • 2.5 Microspheres
  • 2.5.1 Advantages of microspheres
  • 2.6 Phytosomes
  • 2.6.1 Advantages of phytosomes
  • 2.7 Solid lipid nanoparticles
  • 2.7.1 Advantage of SLNs
  • 2.8 Niosomes
  • 2.8.1 Advantages of niosomes
  • 2.9 Proniosomes
  • 2.9.1 Advantages of proniosomes
  • 2.10 Liquid crystals
  • 2.10.1 Advantages of liquid crystals
  • 2.11 Dendrimer
  • 2.11.1 Advantages of dendrimers
  • 2.12 Hydrogels
  • 2.12.1 Advantages of hydrogels
  • 3. Conclusion
  • References
  • Further reading
  • 2
  • Self-emulsifying systems for drug delivery: advances and challenges
  • 1. Introduction
  • 2. Construction of pseudoternary phase diagrams
  • 3. Self-emulsifying systems for oral drug delivery
  • 3.1 General components of SEDDSs for oral drug delivery
  • 3.2 Applications of SEDDSs for oral drug delivery
  • 3.2.1 Liquid SEDDSs for oral drug delivery
  • 3.2.2 Solid SEDDSs (S-SEDDSs) for oral drug delivery
  • 3.2.3 Supersaturable SEDDSs for oral drug delivery
  • 4. Self-emulsifying ocular drug delivery systems
  • 5. Self-emulsifying dermal and transdermal drug delivery systems.
  • 5.1 Transdermal drug delivery
  • 5.2 Targeted delivery to skin strata
  • 6. Self-emulsifying vaginal drug delivery systems
  • 7. Self-emulsifying rectal drug delivery systems
  • 8. Self-emulsifying parenteral drug delivery systems
  • 9. Concluding remarks
  • References
  • 3
  • Gastroretentive drug delivery approaches: concepts, approaches, and applications
  • 1. Introduction
  • 2. Gastroretentive drug delivery systems
  • 3. Anatomy and physiology of the stomach
  • 4. Factors affecting gastric retention ability of a delivery system
  • 5. Approaches to developing GRDDS
  • 5.1 Mucoadhesive systems
  • 5.2 High-density systems
  • 5.3 Floating systems
  • 6. Swellable and expandable systems
  • 7. Magnetic systems
  • 8. Application of gastroretentive dosage forms
  • 9. Conclusion
  • References
  • 4
  • Current advancements in nasopulmonary drug delivery systems
  • 1. Introduction
  • 2. Anatomy and physiology of the respiratory system
  • 3. Advantages and limitations of the nasopulmonary route
  • 3.1 Mucociliary clearance
  • 3.2 Alveolar macrophages
  • 3.3 Enzymatic degradation
  • 3.4 Rapid systemic absorption
  • 4. Factors determining pulmonary drug distribution, effectiveness, and clearance
  • 4.1 Particle size
  • 4.2 Particle shape
  • 4.3 Stealth ability
  • 5. Materials selection for NPDDSSs
  • 6. Applications of NPDDSs
  • 7. Methods of targeting in NPDDSs
  • 8. Next-generation impactor devices as lung simulators
  • Acknowledgement
  • References
  • 5
  • Osmotic drug deliverance systems: concepts, approaches, and applications
  • 1. Introduction
  • 2. Controlled drug deliverance by osmosis machineries
  • 3. Concept of osmosis
  • 4. Basic ingredients of osmotic machineries
  • 4.1 Medication
  • 4.2 Osmotic agent
  • 4.3 Semipenetrable membrane
  • 4.4 Substance for semipenetrable membrane
  • 4.4.1 Cellulose acetate membrane
  • 4.4.2 Compound polyamide membrane.
  • 4.4.3 Arbitrary feature of semipenetrable membrane
  • 4.5 Hole forming factors
  • 4.6 Covering solvent
  • 4.7 Emulsifying agents
  • 4.8 Flux moderating factors
  • 4.9 Wicking factors
  • 4.10 Barrier cortex formers
  • 4.11 Plasticizers
  • 5. Sorts of osmotically controlled drug deliverance devices
  • 5.1 Oral osmotic drug deliverance devices
  • 5.1.1 Single chamber osmotic pump
  • 5.1.1.1 Elementary osmotic pump (EOP)
  • 5.1.1.2 Controlled porosity of osmotic pump (COP)
  • 5.1.1.3 Osmotic erupting osmotic pump
  • 5.1.2 Multichamber osmotic pump
  • 5.1.2.1 Push-pull osmotic pump
  • 5.1.2.2 Osmotic pump with nonextending secondary section
  • 5.1.2.3 Sandwich osmotic tablets (SOTS)
  • 5.2 Implantable osmotic drug deliverance devices
  • 5.2.1 Rose and nelson pump
  • 5.2.2 Higuchi leeper pump
  • 5.2.3 Higuchi theeuwes pump
  • 5.2.4 Oral osmotic capsules
  • 5.2.4.1 OROS-CT
  • 5.2.4.2 Liquid oral release osmotic system (L-OROS)
  • 5.2.4.3 Multiparticulate delayed release systems
  • 5.2.4.4 Telescopic capsule for postponed diffusion
  • 6. Conclusion
  • References
  • 6
  • Nanogels as drug delivery platform
  • 1. Introduction
  • 2. Bibliometric analysis of the nanogels as drug delivery platform
  • 3. Drug release
  • 4. Nanogels as a drug delivery platform in different systems
  • 5. Other applications
  • 6. Global market report
  • 7. Disadvantages of the use of nanogels as drug carriers
  • 8. Conclusions
  • References
  • 7
  • Nanoliposomes as safe and efficient drug delivery nanovesicles
  • 1. Introduction
  • 2. Nanoliposomes preparation
  • 2.1 Chemical components
  • 2.2 Methods of preparation
  • 2.2.1 Thin-layer hydration
  • 2.2.2 Reverse-phase evaporation
  • 2.2.3 Solvent injection
  • 2.2.4 Heating method
  • 2.2.5 Freeze-drying method
  • 2.2.6 Microfluidics channel
  • 2.2.7 Supercritical fluids
  • 3. Methods of drug loading
  • 3.1 Passive loading techniques.
  • 3.2 Active loading techniques
  • 3.2.1 pH gradient
  • 3.2.2 Ammonium sulfate gradient
  • 3.2.3 Metal-ion complexation gradient
  • 4. Analysis and characterization of nanoliposomes
  • 4.1 Particle size and morphology
  • 4.2 Surface charge
  • 4.3 Zeta potential
  • 4.4 Polydispersity index
  • 4.5 Encapsulation efficiency and loading capacity
  • 4.6 Drug release
  • 5. Types of nanoliposomes in drug delivery
  • 5.1 Conventional nanoliposomes
  • 5.2 PEGylated nanoliposomes
  • 5.3 Coated nanoliposomes
  • 5.4 Targeted nanoliposomes
  • 5.5 Stimulus-responsive nanoliposomes
  • 6. Stability and safety of nanoliposomes
  • 7. Applications of nanoliposomes in treatment of human diseases
  • 7.1 Treatment of cancer
  • 7.1.1 Passive delivery
  • 7.1.2 Targeted delivery
  • 7.1.3 Stimulus responsive delivery
  • 7.2 Treatment of neurological disorders
  • 7.3 Treatment of liver diseases
  • 8. Nanoliposomal vaccines
  • 9. Nanoliposomal bioreactors
  • 10. Nanoliposomes in theranostics
  • 11. Marketed nanoliposomes and future challenges
  • 12. Conclusions
  • References
  • 8
  • Transferosomes: a novel nanotechnological approach for transdermal drug delivery
  • 1. Introduction
  • 2. Transferosomes
  • 3. Advantages of transferosomes
  • 4. Limitations of transferosomes
  • 5. Composition of transferosomes
  • 6. Mechanism of penetration of transferosomes across stratum corneum
  • 7. Methods of transferosome preparation
  • 7.1 Vortexing-sonication
  • 7.2 Rotary film evaporation
  • 7.3 Reverse-phase evaporation
  • 7.4 Freeze-thaw method
  • 7.5 Ethanol injection
  • 7.6 Homogenization/extrusion
  • 7.7 Protransferosome-transferosome method
  • 7.8 Microfluidics method
  • 8. Characterizations of transferosomes
  • 8.1 Vesicle size and distribution
  • 8.2 Zeta-potential
  • 8.3 Drug entrapment efficiency
  • 8.4 Surface topography
  • 8.5 Number of vesicles per cubic mm
  • 8.6 Drug content.
  • 8.7 Turbidity measurement
  • 8.8 Measurement of degree of deformability or permeability
  • 8.9 Penetration ability
  • 8.10 Occlusion effects
  • 8.11 Confocal scanning laser microscopy (CSLM) study
  • 8.12 In vitro drug release evaluation
  • 8.13 In vitro skin permeation study
  • 9. Applications of transferosomes
  • 9.1 Protein and peptide delivery
  • 9.2 Corticosteroids
  • 9.3 Anticancer drugs
  • 9.4 Anaesthetics
  • 9.5 Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • 9.6 Antipsycotic drugs
  • 10. Conclusions
  • References
  • 9
  • Niosomes as a promising nanovesicular drug delivery
  • 1. Introduction
  • 2. Composition of niosomes
  • 2.1 Nonionic surfactants
  • 2.2 Cholesterol
  • 2.3 Charge inducer molecules
  • 2.4 Hydration medium
  • 3. Factors affecting niosomal formulation
  • 3.1 Surfactant
  • 3.2 Cholesterol
  • 3.3 Drug
  • 3.4 Hydration condition
  • 3.5 Resistance to osmotic stress
  • 3.6 Method of preparation
  • 4. Types of niosomes
  • 5. Fabrication methods of niosomes
  • 5.1 Thin layer evaporation/handshaking
  • 5.2 Reverse phase evaporation
  • 5.3 Bubble
  • 5.4 Ether injection
  • 5.5 Sonication
  • 5.6 Microfluidization
  • 5.7 Transmembrane pH gradient
  • 5.8 Membrane extrusion
  • 5.9 Single pass
  • 5.10 Handjani-vila
  • 5.11 Heating
  • 5.12 Freeze and thaw
  • 5.13 Enzymatic
  • 5.14 Microfluidic hydrodynamic focusing
  • 5.15 Dehydration-rehydration
  • 5.16 Supercritical carbon dioxide fluid (scCO2)
  • 5.17 Lipid injection
  • 5.18 Emulsion
  • 5.19 Formation of niosomes from proniosomes
  • 6. Methods for controlling the size of niosomes
  • 6.1 Fractionation
  • 6.2 Homogenization
  • 6.3 Extrusion
  • 7. Niosome purification
  • 7.1 Dialysis
  • 7.2 Reverse dialysis
  • 7.3 Gel filtration/column chromatography
  • 7.4 Centrifugation
  • 7.5 Ultra-centrifugation
  • 8. Characterization of niosomes
  • 8.1 Size, morphology, and size distribution.