The science of glaucoma management : from translational research to next-generation clinical practice /

The Science of Glaucoma Management: From Translational Research to Next-Generation Clinical Practice bridges the gap between laboratory research and clinicians by bringing the latest promising research directly from researchers to clinicians long before they translate into clinical advances, and oft...

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Bibliographic Details
Corporate Author:	ScienceDirect (Online service)
Other Authors:	Gillmann, Kevin, Mansouri, Kaweh
Format:	eBook
Language:	English
Published:	London : Academic Press, 2023.
Subjects:	Glaucoma > Treatment. Glaucoma > therapy Glaucome > Traitement. Glaucoma > Treatment Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Front Cover
The Science of Glaucoma Management
Copyright Page
Dedication
Contents
List of contributors
Foreword
Preface
1 Currently accepted glaucoma practice
1 Glaucoma pathology
1.1 Quick reference summary
1.2 Introduction to glaucomatous pathology
1.2.1 Glaucoma classification
1.2.2 Worldwide prevalence
1.2.3 The financial burden of glaucoma
1.2.4 Risk factors and the continuum of intraocular pressure
1.3 Causes of glaucomatous pathology (linking ocular hypertension to optic nerve degeneration)
1.3.1 Clinical observations
1.3.2 Compression and strain on the optic nerve head
1.3.3 Age-related mechanisms
1.3.4 Immune mechanisms
1.3.5 Vascular mechanisms
1.3.6 Translaminar pressure gradient
1.3.7 Metabolic mechanisms
1.3.8 Glaucomatous pathology at the optic nerve head-a unifying hypothesis
1.4 The processes of neurodegeneration
1.4.1 Axonal degeneration
1.4.2 Dendritic arbor remodeling
1.4.3 Neuronal loss by intrinsic apoptosis
1.4.4 Signaling of apoptosis in glaucoma
1.5 Unmet needs
References
2 Epidemiology of glaucoma
2.1 Quick reference summary
2.2 Global epidemiology of glaucoma
2.3 New trends in glaucoma epidemiology
2.3.1 Regional differences in prevalence and the ongoing epidemiological transition
2.3.2 Incidence of glaucoma
2.3.3 Myopia epidemic and glaucoma
2.3.4 Risk factors for primary open-angle glaucoma
2.3.4.1 Age
2.3.4.2 Race
2.3.4.3 Family history
2.3.4.4 Intraocular pressure
2.3.4.5 Corneal properties
2.3.4.6 Optic disk features
2.3.4.7 Myopia
2.3.4.8 Systemic risk factors
2.3.5 Risk factors for primary angle-closure glaucoma
2.4 Discussion
2.4.1 Implications for current practice
2.4.2 The future of glaucoma practice
References
3 Diagnosis and investigations in glaucoma.
3.1 Quick reference summary
3.1.1 History
3.1.2 Examination
3.1.3 OCT
3.1.4 Optic nerve head
3.1.5 Retinal nerve fiber layer
3.1.6 Macula
3.1.7 Visual fields
3.2 Conclusion
References
4 Follow-up
4.1 Quick reference summary
4.2 Intraocular pressure and general considerations
4.3 Optic nerve head and retinal nerve fiber layer
4.4 Visual field
References
5 Glaucoma management
5.1 Quick reference summary
5.2 Aims of management
5.3 Management protocol
5.4 First-line treatments
5.4.1 Selective laser trabeculoplasty
5.4.2 Topical medications
5.4.3 Instillation technique and compliance
5.5 Surgical options
5.6 Angle-closure glaucoma
References
6 Section summary: into the unknown-identifying the needs
6.1 Glaucoma detection and screening
6.2 Early diagnosis and identification of progression
6.3 Pressure-independent treatments
6.4 Minimally invasive glaucoma surgery
6.5 Pathophysiology and biomarkers
6.6 Patient-centered care and personalized medicine
2 Pathophysiology and investigation methods
7 Considerations for an effective screening program for glaucoma
7.1 Quick reference summary
7.2 Review of accepted practice
7.2.1 Rationale for screening
7.2.2 Current consensus
7.3 Considerations for an effective screening program
7.3.1 World Glaucoma Association Criteria for screening
7.3.1.1 Pivotal trials to date
7.3.1.2 Validation of screening programs
7.3.1.3 Updates in the cost-benefit analysis for glaucoma screening
7.3.1.4 Glaucoma screening should not focus on risk factors
7.3.1.5 Considerations for a suitable testing strategy
7.3.1.6 The challenge with follow-up
7.3.2 Novel technologies for glaucoma screening
7.3.2.1 Telemedicine screening
7.3.2.2 Genetics for screening.
7.3.2.3 Artificial intelligence for screening
7.4 Discussion and conclusion
7.4.1 Practical recommendations for effective glaucoma screening
7.4.2 The future of glaucoma screening practice
References
8 Vascular health and glaucoma
8.1 Quick reference summary
8.2 Review of the currently accepted knowledge
8.2.1 Association between vascular dysfunction and glaucoma
8.2.1.1 Vascular risk factors in glaucoma pathogenesis
8.2.1.2 Genome-wide association studies
8.2.1.3 Preclinical studies
8.2.2 Ocular perfusion pressure and ocular blood flow
8.2.2.1 Introduction to ocular blood flow and ocular perfusion pressure
8.2.2.2 Regulation of ocular blood flow and ocular perfusion pressure
8.2.3 Assessment of ocular blood flow and vascular changes
8.3 Novel concepts on vascular factors in glaucoma
8.3.1 Systemic vascular risk factors for glaucoma
8.3.1.1 Blood pressure and glaucoma
8.3.1.2 Diabetes and glycemic control
8.3.1.3 Hyperlipidemia
8.3.1.4 Atherosclerotic disease
8.3.1.5 Migraine and vasospasm
8.3.2 Management of systemic vascular risk factors and glaucoma
8.3.2.1 Antihypertensive use and glaucoma
8.3.2.2 Hypoglycemic therapy and glaucoma
8.3.2.3 Statin use and glaucoma
8.3.3 Ocular blood flow disruptions associated with glaucoma
8.3.3.1 Impaired autoregulation in glaucoma
8.3.3.2 Disruption of neurovascular coupling
8.3.4 Novel approaches to glaucoma diagnosis and management
8.3.4.1 Precision medicine-driven targets for optimizing treatment of glaucoma patients based on genetic profile
8.3.4.2 Personalization of treatment using chronotherapy/individualized circadian rhythms
8.3.4.3 Novel diagnostic tools that consider vascular autoregulation
8.3.4.4 Development and evaluation of novel therapeutics that alter perfusion.
8.4 Discussion on current and future implications
8.4.1 Choice of treatment for vascular disease and glaucoma
8.4.1.1 Management of modifiable vascular risk factors in glaucoma
8.4.1.2 Selection of glaucoma medications based on systemic conditions
8.4.2 Clinical guidelines for vascular disease management in glaucoma patients
8.4.2.1 Defining best practice for treatment of systemic vascular disease in glaucoma patients
8.4.2.2 Guidelines for selective glaucoma screening
8.4.3 Novel diagnostic and therapeutic tools for vascular health in glaucoma
8.5 Conclusion
References
9 The role of circadian and extrinsic intraocular pressure fluctuations
9.1 Introduction
9.2 Research and technological advancements
9.3 Implications in clinical practice
References
10 Pseudoexfoliative glaucoma: epidemiology, pathophysiology, and clinical implications
10.1 Quick reference summary
10.2 Introduction
10.3 Epidemiology
10.3.1 Prevalence
10.3.2 Incidence
10.3.3 Natural history and prognosis
10.4 Pathophysiology
10.4.1 Etiology
10.4.2 Pathogenesis
10.4.3 Mechanisms of glaucoma development
10.4.4 Biomarker
10.5 Clinical implications
10.5.1 Diagnosis
10.5.2 Management
10.5.3 Medical therapy
10.5.4 Laser therapy
10.5.5 Surgical therapy
10.6 Conclusions and perspective
References
11 Angle-closure glaucoma: epidemiology, pathophysiology, and clinical impact
11.1 Quick reference summary
11.2 Overview
11.3 Novel concepts/promising research
11.3.1 Epidemiology and pathophysiology
11.3.1.1 Genetic biomarkers
11.3.1.2 Aqueous humor and blood biomarkers
11.3.2 Anterior segment imaging and current understanding of primary angle-closure glaucoma
11.3.2.1 Anterior segment optical coherence tomography
11.3.2.2 Ultrasound biomicroscopy.
11.3.2.3 Scanning peripheral anterior chamber depth analyzer
11.3.2.4 Scheimpflug photography
11.3.2.5 Gonio-photographic systems
11.3.3 Current evidence on the effectiveness of interventions for primary angle-closure glaucoma disease
11.4 Discussion
11.4.1 Implications for current practice
11.4.2 The future of glaucoma practice
References
12 The role of optical coherence tomography angiography in glaucoma
12.1 Quick reference summary
12.2 Introduction
12.3 Optical coherence tomography angiography in glaucoma
12.3.1 Optical coherence tomography angiography scanning regions and parameters of interest in glaucoma
12.3.1.1 Optic disk optical coherence tomography angiography scan
12.3.1.2 Macular optical coherence tomography angiography scan
12.3.1.3 Artifacts in optical coherence tomography angiography imaging
12.3.1.4 Optical coherence tomography angiography parameters of interest in glaucoma
12.3.1.5 Repeatability and reproducibility
12.3.1.6 Factors affecting optical coherence tomography angiography parameters in normal eyes
12.3.2 Optical coherence tomography angiography in primary open-angle glaucoma
12.3.2.1 Optical coherence tomography angiography in primary open-angle glaucoma diagnosis
12.3.2.2 Optical coherence tomography angiography in primary open-angle glaucoma progression
12.3.3 Optical coherence tomography angiography in other subtypes of glaucoma
12.3.3.1 Normal-tension glaucoma
12.3.3.2 Pseudoexfoliation glaucoma
12.3.3.3 Primary angle-closure glaucoma
12.4 Discussion
12.4.1 Implications for current practice
12.4.2 Implications for future glaucoma practice
References
13 Structural testing modalities: RNFL, GCIPL, BMO-MRW, or vessel density?
13.1 Quick reference summary.