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Receptor tyrosine kinases in neurodegenerative and psychiatric disorders /

Overexpression of receptor tyrosine kinases (RTKs) has been implicated in cancer.Increasing evidence suggests that dysregulation of RTKs is reported in many neurodegenerative and psychiatric disorders.Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders provides a fundamental, pr...

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Bibliographic Details
Corporate Author: ScienceDirect (Online service)
Other Authors: Mansour, Heba Mohamed
Format: eBook
Language:English
Published: [S.l.] : Academic Press, 2023.
Subjects:
Protein-tyrosine kinase > Receptors.
Nervous system > Degeneration > Treatment.
Mental illness > Treatment.
Mental Disorders > therapy
Protéine-tyrosine kinase > Récepteurs.
Maladies mentales > Traitement.
Mental illness > Treatment
Nervous system > Degeneration > Treatment
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • 5.1.4 The impact of the immune system in psychiatric disorders
  • 5.1.5 Brain structural alterations in psychiatric disorders
  • 5.1.6 Altered functional connectivity in psychiatric disorders
  • 5.2 Unmet clinical needs of psychiatric disorders
  • References
  • 2
  • Receptor tyrosine kinases: an overview
  • 1. Introduction
  • 2. Receptor tyrosine kinases families and subfamilies
  • 2.1 Structural organization of receptor tyrosine kinases
  • 2.1.1 The epidermal growth factor receptors (EGFR/ErbB) family
  • 2.1.2 The insulin and insulin-like growth factor receptors (INSR/IGFR) family
  • 2.1.3 The platelet-derived growth factor receptors (PDGFRs) family
  • 2.1.4 The vascular endothelial growth factor receptor (VEGFR) family
  • 2.1.5 The fibroblast growth factor receptors (FGFRs) family
  • 2.1.6 The colon carcinoma kinase 4 (CCK) receptor
  • tyrosine-protein kinase-like 7 (PTK-7) receptor family
  • 2.1.7 The tropomyosin receptor kinase (Trk) family
  • 2.1.8 The Wnt receptor family
  • 2.1.9 The anaplastic lymphoma kinase (ALK) receptor family
  • 2.1.10 The mesenchymal-epithelial transition factor (MET) receptor family
  • 2.1.11 The tyrosine kinases with immunoglobulin and epidermal growth factor homology domains (TIE) receptor family
  • 2.1.12 The Ephrin (Eph) receptor family
  • 2.1.13 The REarranged during transfection (Ret) receptor family
  • 2.1.14 The (Tyro3-Axl-Mer) TAM receptors family
  • 3. Receptor tyrosine kinase signaling
  • 3.1 Different activated mechanisms of RTKs
  • 3.2 Ligand-induced dimerization of RTK extracellular regions
  • 3.3 Tropomyosin receptor kinase A (TrkA): ligand-mediated dimerization
  • 3.4 KIT: a ligand-mediated dimer containing connections to the receptors
  • 3.5 FGFR: multiple contacts with FGF and heparin molecules
  • 3.6 The extreme activation of EGFR/ErbB family
  • 3.7 Activation of intracellular kinase domains.
  • 4.4.2 Signaling pathways of VEGFRs in CNS
  • 4.4.3 Role in VEGFRs CNS
  • 4.5 Fibroblast growth factor receptor (FGFR)
  • 4.5.1 Structural basis for activation of FGFR in CNS
  • 4.5.2 Signaling pathway of FGFRs in CNS
  • 4.5.3 Role of FGFRs in CNS
  • 4.6 Cholecystokinin (CCK) receptor family
  • 4.6.1 Structural basis for activation of CCK receptors in CNS
  • 4.6.2 Signaling pathways of CCK receptors in CNS
  • 4.6.3 Role of CCK receptors in CNS
  • 4.7 Nerve growth factor receptors (NGFRs)
  • 4.7.1 Structural basis for activation of nerve growth factor receptors in CNS
  • 4.7.2 Signaling pathways of NGFR in CNS
  • 4.8 Hepatocyte growth factor (HGF) receptors
  • 4.8.1 Structural basis for activation of hepatocyte growth factor receptors
  • 4.8.2 Signaling pathways of HGF receptors in CNS
  • 4.8.3 Role of HGF receptors in CNS
  • 4.9 Erythropoietin-producing human hepatocellular (Eph) receptors
  • 4.9.1 Structural basis for activation of erythropoietin-producing human hepatocellular receptors in CNS
  • 4.9.2 Eph-ephrin bidirectional signaling pathways in CNS
  • 4.9.3 Role of ephrine receptors in CNS
  • 4.10 Tyro3, Axl, and Mertk (TAM) receptors
  • 4.10.1 Structural basis for activation of TAM receptors
  • 4.10.2 Signaling pathways of TAM receptors in CNS
  • 4.10.3 Role of TAM receptors in CNS
  • 4.11 RYK receptors
  • 4.11.1 Structural basis for activation of RYK receptors
  • 4.11.2 Signaling pathways of RYK receptors in CNS
  • 4.11.3 Role in RYK receptors in CNS
  • 4.12 Muscle-specific kinase (MuSk) receptors
  • 4.12.1 Structural basis for activation of muscle-specific kinase receptors
  • 4.12.2 Signaling pathways of MuSK receptors in CNS
  • 4.12.3 Role of MuSK receptors in CNS
  • 4.13 Discoidin domain receptor (DDR)
  • 4.13.1 Structural basis for activation of discoidin domain receptor
  • 4.13.2 Signaling pathways of discoidin domain receptors in CNS.