Nanomedicine : technologies and applications /

Nanomedicine: Technologies and Applications, Second Edition provides an important review of this exciting technology and its growing range of applications. In this new edition, all chapters are thoroughly updated and revised, with new content on antibacterial technologies and green nanomedicine. Sec...

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Bibliographic Details
Corporate Author:	ScienceDirect (Online service)
Other Authors:	Webster, Thomas J., 1971- (Editor)
Format:	eBook
Language:	English
Published:	Cambridge, MA : Woodhead Publishing, 2023.
Edition:	Second edition.
Series:	Woodhead Publishing series in biomaterials.
Subjects:	Nanomedicine. Medical technology. Nanomedicine Medical Laboratory Science Nanomédecine. Technologie médicale. Medical technology Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Intro
Nanomedicine: Technologies and Applications
Copyright
Dedication
Contents
Contributors
Preface: Nanomedicine: Proven and getting stronger
References
Chapter 1: Trends in nanomedicine
1.1. Diagnosis/imaging
1.2. Therapeutic applications
1.3. Antiviral/antibacterial
1.4. Advanced nanoparticles (NPs)
1.5. Immunization/vaccine production
1.6. Drug delivery
1.7. Stem cells
1.8. Future nanomedicine efforts
References
Chapter 2: Application and translation of nano calcium phosphates in biomedicine
2.1. Introduction
2.2. Calcium phosphate coatings
2.2.1. High-temperature fabrication
2.2.1.1. Plasma spraying
2.2.1.2. Sol-gel deposition
2.2.1.3. Hydrothermal coating
2.2.1.4. Pulsed laser
2.2.1.5. High velocity oxy-fuel spraying
2.2.1.6. Metal-organic chemical vapor deposition
2.2.2. Ambient temperature fabrication
2.2.2.1. Biomimetic coating
2.2.2.2. Electrophoretic deposition
2.2.2.3. Electrochemical deposition
2.2.3. Summary
2.3. Calcium phosphate scaffolds
2.3.1. Bone void fillers
2.3.2. Calcium phosphate cement (CPC)
2.3.3. Calcium phosphate putty
2.3.4. Summary
2.4. Calcium phosphate nanoparticles (CaP-NPs)
2.4.1. Tissue engineering/regeneration scaffolds
2.4.2. Gene transfection
2.4.3. Drug/cargo delivery
2.4.4. Fluorescent agents
2.4.5. Summary
2.5. Translation status and outlook
Acknowledgments
References
Chapter 3: Functionalized magnetic nanoparticles for treating bone diseases
3.1. Introduction
3.1.1. Magnetic nanoparticles
3.1.2. Osteoporosis and bone loss
3.1.3. Limitations of present methods in the treatment of osteoporosis
3.1.4. Iron oxide magnetic nanoparticles
3.2. Synthesis of iron oxide magnetic nanoparticles
3.2.1. Chemical synthesis by coprecipitation.
3.2.2. The reaction in a restraint environment
3.2.3. Hydrothermal and high-temperature reaction
3.2.4. Sol-gel method
3.2.5. Polyol method
3.2.6. Flow injection method
3.2.7. Electrochemical method
3.2.8. Aerosol/vapor methods
3.2.9. Sonolysis
3.3. Surface modification of iron oxide magnetic nanoparticles
3.3.1. Functionalization of iron oxide magnetic nanoparticles
3.3.2. Calcium phosphate coatings on iron oxide magnetic nanoparticles
3.4. Biological applications of magnetic nanoparticles
3.4.1. Hyperthermia
3.4.2. Cell transfection
3.4.3. Targeted drug delivery
3.4.4. Scaffolds
3.5. Conclusions
References
Chapter 4: Nanotechnology for DNA and RNA delivery
4.1. Introduction on DNA and RNA delivery
4.2. Advanced DNA/RNA delivery approaches in nanotechnology
4.2.1. Physical methods
4.2.2. Chemical and material methods
4.2.3. Biomimetic inspired methods
4.3. Nanomaterial applications for DNA/RNA delivery
4.3.1. Anticancer treatment
4.3.2. Improved tissue/organ functions
4.3.3. Antivirus applications
4.3.4. Novel vaccines
4.3.5. Molecular probes and images
4.4. Conclusions and future prospects
4.4.1. Multifunctionality and highly composite structures
4.4.2. Simple to produce and easy to take
References
Chapter 5: Gold nanoshells for imaging and photothermal ablation of cancer
5.1. Introduction
5.2. Nanotechnology and cancer treatment
5.3. Gold nanoshells
5.4. Surface plasmon resonance properties
5.5. Laser-induced thermal effects
5.6. Advantages of nanoshells in biomedicine
5.7. Synthesis and bioconjugation
5.8. Applications of gold nanoshells
5.8.1. Gold nanoshells as imaging tracers
5.8.2. Gold nanoshells for cancer thermal ablation
5.8.3. Gold nanoshells as carriers of therapeutic agents.
5.9. Conclusion and future trends
References
Chapter 6: Microfluidics: A versatile tool for developing, optimizing, and delivering nanomedicines
6.1. Introduction
6.2. Types of microfluidics
6.2.1. Extracellular complex microenvironment-based microfluidics
6.2.2. 3-D printing-based microfluidics
6.2.3. PDMS and PMMA-based microfluidics
6.2.4. Microreactor-based microfluidics
6.2.5. Droplet-based microfluidics
6.2.6. Organ-on-a-chip
6.2.7. Microscale cell sorters
6.3. Nanomedicine
6.3.1. Polymeric nanoparticles
6.3.2. Inorganic nanoparticles
6.3.3. Organic-inorganic hybrid nanoparticles
6.3.4. Nanocapsules
6.3.5. Nanoliposomes
6.3.6. Nanoemulsions
6.3.7. Niosomes
6.3.8. Nanocrystalline drugs
6.3.9. Lipid-polymer hybrid nanoparticles
6.3.10. Polyionic complexes
6.4. Conclusion
References
Chapter 7: Bioinspired advanced nanomaterials for infection control and promotion of bone growth
7.1. Introduction
7.2. Alginate
7.3. Chitosan
7.4. Collagen
7.5. Gelatin
7.6. Silk
7.7. Others
7.8. Conclusions and future perspectives
References
Chapter 8: Nanostructured materials for bone tissue replacement
8.1. Introduction
8.2. Overview of bone replacement strategies
8.2.1. Bone autografts
8.2.2. Bone allografts
8.2.3. Bone xenografts
8.2.4. Artificial bone substitutes
8.3. Why nanomaterials for bone replacement?
8.4. Nanomaterial-based bone substitutes
8.4.1. Surface modification and nanocoating
8.4.2. Nanomaterials as fillers
Conclusions
References
Chapter 9: Nanocomposites for cartilage regeneration
9.1. Introduction
9.1.1. Cartilage
9.1.1.1. Anatomy and function
9.1.1.2. Microstructural and cellular organization
9.1.1.3. Properties and physiological functions of cartilage.
9.1.1.4. Cartilage degeneration and current treatments
Microfracture
Autologous chondrocyte transplantation
Cartilage transplantation
Tissue engineering
Other less invasive options for treating cartilage-related problems
9.2. Design criteria and considerations for cartilage biomaterials
9.2.1. Biocompatibility
9.2.2. Degradation properties
9.2.3. Mechanical properties
9.2.4. Porosity and pore size
9.2.5. Surface properties
9.2.6. Biologically active agents
9.2.6.1. Growth factors
9.2.6.2. Bioactive molecules
9.2.7. Cell delivery
9.2.7.1. Differentiated cells
9.2.7.2. Undifferentiated cells
9.3. Biomaterials for cartilage regeneration
9.3.1. Natural materials
9.3.2. Synthetic materials
9.3.3. Nanocomposites
9.3.3.1. Organic-organic composites
Natural organic-organic composites
Synthetic polymer-polymer composites
9.3.3.2. Organic-inorganic composites
Collagen-hydroxyapatite composites
Polymer-hydroxyapatite composites
9.4. Scaffold fabrication
9.4.1. Electrospinning nanofibers
9.4.1.1. Conventional electrospinning
9.4.1.2. Near-field electrospinning
9.4.1.3. Cell electrospinning
9.4.2. Porogen removal-induced 3-D structures
9.4.2.1. Solvent casting and particulate leaching
9.4.2.2. Gas foaming
9.4.2.3. Freeze-drying
9.4.3. Rapid prototyping
9.4.3.1. 3-D inkjet printing
9.4.3.2. Aerosol jet printing
9.4.4. 3-D bioprinting
9.4.4.1. Inkjet-based bioprinting
10.4.4.2 Laser-assisted bioprinting
9.4.4.3. Extrusion-based bioprinting
9.5. Conclusions and future trends
References
Chapter 10: Biomimetic nanofiber-enabled rapid creation of skin grafts
10.1. Introduction
10.2. Autologous skin tissue engineering for wound healing
10.3. The effects of the microenvironment on the formation of skin substitutes.
10.4. Production of biomimetic nanofibers using electrostatic spinning
10.4.1. Pore size
10.4.2. Fiber diameter
10.4.3. Fiber composition
10.4.4. Fiber spatial arrangement
10.5. Layer-by-layer assembly of cells into 3D construct using electrospun nanofibers
10.6. Rapid formation of skin grafts using the nanofiber-enabled cell layering approach
10.7. Future trends and challenges
10.8. Conclusion
Acknowledgments
References
Chapter 11: Green-synthesized metallic nanoparticles for antimicrobial applications
11.1. Bacterial diseases and antibiotic resistance in bacteria
11.2. Green nanotechnology as a potential alternative
11.3. Green-synthesized metallic nanoparticles as antimicrobial agents
11.3.1. Green-synthesized gold nanoparticles (AuNPs)
11.3.1.1. Bacterial synthesis of AuNPs
11.3.1.2. Fungal synthesis of AuNPs
11.3.1.3. Plant-mediated synthesis of AuNPs
11.3.2. Green-synthesized silver nanoparticles (AgNPs)
11.3.2.1. Bacterial synthesis of AgNPs
11.3.2.2. Fungal synthesis of AgNPs
11.3.2.3. Plant synthesis of AgNPs
11.3.3. Green-synthesized palladium nanoparticles (PdNPs)
11.3.3.1. Fungal synthesis of PdNPs
11.3.3.2. Plant synthesis of PdNPs
11.3.4. Green-synthesized platinum nanoparticles
11.3.4.1. Fungal synthesis of PtNPs
11.3.4.2. Plant synthesis of PtNPs
11.3.5. Green-synthesized magnetic nanoparticles: Iron nanoparticles (FeNPs)
11.3.5.1. Bacterial synthesis of FeNPs
11.3.5.2. Fungal synthesis of FeNPs
11.3.5.3. Plant synthesis of FeNPs
11.3.6. Green-synthesized metalloid nanoparticles: Tellurium nanoparticles (TeNPs)
11.3.6.1. Bacteria-mediated NPs
11.3.6.2. Fungi-mediated NPs
11.3.6.3. Plant-mediated NPs
11.4. Conclusion
References
Chapter 12: Green nanotechnology and nanoselenium for biomedical applications.