Neurostimulation for epilepsy : advances, applications and opportunities /
Neurostimulation for Epilepsy: Advances, Applications, and Opportunities comprehensively reviews the diverse array of neurostimulation technologies currently in use and in development for the treatment of epilepsy. The book covers basic mechanisms of neurostimulation, technical characteristics of ap...
| Corporate Author: | |
|---|---|
| Other Authors: | |
| Format: | eBook |
| Language: | English |
| Published: |
London, San Diego, CA :
Academic Press,
2023.
|
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Intro
- Neurostimulation for Epilepsy: Advances, Applications, and Opportunities
- Copyright
- Contents
- Contributors
- Preface
- Acknowledgments
- Chapter 1 Principles of neurostimulation
- Introduction
- Technical and biophysical background of neurostimulation
- Targets for neurostimulation in epilepsy
- Antiepileptic effects of specific stimulus forms
- High-frequency stimulation (HFS)
- Low-Frequency Stimulation (LFS)
- DC stimulation
- Stimulation of peripheral nerves: Vagus nerve stimulation
- Stimulation of network hubs: Anterior and centromedian nuclei of the thalamus
- Combining neuromodulatory approaches
- Closed-loop stimulation
- Cognitive tolerability of therapeutic brain stimulation
- References
- Chapter 2 Neurostimulation device technology
- Introduction
- Neuromodulation technology
- Neural interface model
- Neural biosignal sensing
- Neural stimulation
- Limitation and safety
- Commercially available implantable neuromodulation devices for epilepsy
- Direction of future neuromodulation technology
- References
- Chapter 3 Vagus nerve stimulation
- Introduction
- History
- Efficacy
- Long-term clinical studies
- Postapproval long-term outcomes
- New features, pediatric, elderly, and special populations
- Mechanism of action
- Experimental studies
- Clinical studies
- Selection of candidates
- Initiation and maintenance
- Complications and adverse effects
- Advantages and disadvantages
- Future developments
- Addendum
- References
- Chapter 4 Responsive neurostimulation
- Theoretical underpinnings
- Temporal and spatial specificity
- Open- versus closed-loop stimulation
- Acute disruptive and long-term neuromodulatory effects
- RNS System
- Detection
- Electrocorticograms (ECoGs)
- Stimulation
- Trending
- Clinical data
- Pivotal trial
- Study design
- Results
- Safety.
- Post hoc analyses of pivotal trial data
- Seven-year neocortical outcomes
- Seven-year mesial temporal outcomes
- Quality of life
- Neuropsychological outcomes
- Real-world trial
- Nine-year long-term extension data
- Utilization of long-term trending data
- Identification of intrinsic patient-specific variations
- Illustrate effects of other treatments
- Inform future surgeries
- Sudden unexpected death in epilepsy (SUDEP)
- MRI compatibility
- Practical considerations and troubleshooting
- High impedances during implantation
- High impedances at a return visit
- Side effects from stimulation
- Scalp EEG artifact
- Failure of seizures to respond adequately to standard stimulation parameters
- Targets for responsive neurostimulation
- Cortical RNS targets
- White matter targets
- Subcortical targets: Thalamic
- Subcortical targets: Thalamic-Anterior nucleus
- Subcortical targets: Thalamic-Centromedian nucleus
- Subcortical targets: Pulvinar
- Subcortical targets: Heterotopias
- Future directions
- Conclusions
- Acknowledgments
- References
- Chapter 5 Deep brain stimulation (DBS) of thalamus for epilepsy
- Brief historical background
- Laboratory studies
- ANT DBS
- Early ANT DBS clinical studies
- SANTE trial
- Efficacy in SANTE
- What improved in the SANTE study?
- Adverse events in SANTE
- Targeting ANT for DBS
- Practical management of ANT DBS
- Other thalamic DBS targets
- Centromedian nucleus (CM)
- Pulvinar
- Dorsalis medialis (DM)
- Nucleus reticularis of thalamus (nRT)
- DBS for status epilepticus
- Conclusions and future directions
- References
- Chapter 6 Epicranial focal cortex stimulation with the EASEE system
- Background
- Device components
- The implantable pulse generator-EASEE Power
- The electrode-EASEE Lead
- Electrical fields
- Device programming
- Patient controller.
- Clinical trials
- Future avenues
- References
- Chapter 7 Noninvasive brain stimulation for epilepsy
- Introduction
- Transcranial magnetic stimulation (TMS)
- Transcranial direct/alternating current stimulation (tDCS/tACS)
- Transcutaneous vagus nerve stimulation (tVNS)
- Transcutaneous trigeminal nerve stimulation (TNS)
- Low-intensity focused ultrasound (FUS)
- Vision for the future
- References
- Chapter 8 Applications of long-term data from neurostimulation devices
- Introduction
- Responsive Neurostimulation
- Chronic electroencephalography (cEEG)
- Seizure tracking
- Seizure lateralization and localization
- Characterization of clinical events
- Characterization of seizure cycles
- Measuring effects of medications and other substances
- Research applications
- Deep brain stimulation (DBS) for epilepsy
- Local field potentials and brain sensing
- Vagus nerve stimulation
- Long-term events and trends
- Conclusion
- References
- Chapter 9 Next-generation brain sensing, stimulation, and adaptive control devices for epilepsy
- Introduction
- Current state of ESB devices
- Solutions to some current clinical gaps and opportunities
- Conclusions
- References
- Chapter 10 Quality of life, neurocognitive outcomes, and mood effects with neurostimulation devices
- Introduction
- Vagus nerve stimulation (VNS)
- Quality of life measures
- Neurocognitive outcomes
- Depression and anxiety
- Responsive neurostimulation (RNS)
- Quality of life measures
- Neurocognitive outcomes
- Depression and anxiety
- Deep brain stimulation (DBS)
- Quality of life measures
- DBS-ANT and the SANTE trial
- DBS-CMN
- DBS-HC
- DBS-cerebellum
- Neurocognitive outcomes
- DBS-ant
- DBS-CMN
- DBS-HC
- DBS-cerebellum
- Depression and anxiety
- DBS-ANT
- Other targets
- Limitations and future opportunities
- References.