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Ionizing Radiation and the Immune Response - Part A.

Ionizing Radiation and the Immune Response, Volume 376, Part A reviews the latest updates on the immune response induced by ionizing radiations. Sections discuss NK functions in radio-induced immune response, TRT and immune response, Radio-induced immune response and lipid metabolism, Effect of prot...

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Bibliographic Details
Main Author: Galluzzi, Lorenzo
Corporate Author: ScienceDirect (Online service)
Other Authors: Mirjolet, Celine
Format: eBook
Language:English
Published: San Diego : Elsevier Science & Technology, 2023.
Series:Issn Series.
Subjects:
Immune response.
Ionizing radiation > Health aspects.
Réaction immunitaire.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Intro
  • Ionizing Radiation and the Immune Response
  • Part A
  • Copyright
  • Contents
  • Contributors
  • Chapter One: Are charged particles a good match for combination with immunotherapy? Current knowledge and perspectives
  • 1. Introduction
  • 2. Charged particles: physics and biology
  • 2.1. Physical characteristics of charged particle therapy as opposed to photon therapy
  • 2.2. Resulting biological effects and enhanced biological effectiveness for cell death related effects
  • 3. Impact of charged particles on the immune response
  • 3.1. Biological differences with respect to immunogenicity of the cell death modality
  • 3.2. Pre-clinical studies suggesting a match of charged particles with immunotherapy
  • 3.3. Impact on immune cells and the tumor immune microenvironment
  • 3.4. Sparing of normal tissue leads to reduced lymphopenia
  • 3.5. Potential for charged particles in combination with immunotherapy and clinical studies
  • 4. Future perspectives
  • 5. Conclusions
  • Reference
  • Chapter Two: Radiation-induced immune response in novel radiotherapy approaches FLASH and spatially fractionated radiothe ...
  • 1. Introduction
  • 2. FLASH radiation therapy and the immune system
  • 2.1. Immune cell sparing in blood and normal tissues
  • 2.2. FLASH-RT effects on tumor immune microenvironment
  • 2.3. FLASH-RT effects on cytokines production and distant effects
  • 2.4. Combination of FLASH-RT with immunotherapy
  • 3. Spatially fractionated radiotherapy and radiation-induced immune response
  • 3.1. Impact of SFRT on the tumor microenvironment
  • 3.2. SFRT effects on inflammation and cytokine secretion
  • 3.3. SFRT impact on peripheral immune cells
  • 3.4. Abscopal effect and distant effect of healthy tissue irradiation
  • 3.5. Long-term antitumor immunity
  • 3.6. Combination of SFRT and immunotherapy
  • 4. Conclusions
  • Acknowledgments
  • References
  • Chapter Three: Impact of radiation therapy on healthy tissues
  • 1. Acute normal tissue reactions associated with an inflammatory response
  • 1.1. Clinical aspects
  • 1.2. Radioprotection against oxidative stress
  • 1.3. Pro-inflammatory mediators
  • 1.4. Macrophages roles in early normal tissue response
  • 2. Late normal tissue effects
  • 2.1. Radiation-induced stromal changes