rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: REGULATORY GENOME IN ADAPTATION, EVOLUTION, DEVELOPMENT, AND DISEASE
  name:
    name part: SMITH, MOYRA.
    role:
      role term: creator
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: Electronic books.
  origin info:
    place:
      place term: xx
    place:
      place term: S.l.]
    publisher: ELSEVIER ACADEMIC PRESS
    date issued: 2023
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource
  abstract: The Regulatory Genome in Adaptation, Evolution, Development, and Disease synthesizes insights from recent genomic and gene expression studies across organisms, from humans to plants, animals, and single cell life, exploring common roles gene regulation plays in adaptive evolution, developmental biology and susceptibility to disease. The book sheds light on gene regulation across evolutionary timelines, illuminating new areas of focus and future research. Chapters consider key elements in gene expression regulation, fundamentals of genomic alterations over time, and in response to environmental and local conditions, epigenetics in adaptive evolution, and adaptive gene regulation in healthy processes and developmental biology, and in disease biology. Throughout the book, a comparative approach is adopted across organisms to highlight common evolutionary themes and genome diversity revealed by recent sequencing and GWAS studies, as well as how this informs our understanding of human adaptive evolution. The book finishes by detailing how we can use this knowledge to impact disease outcomes and healthy human metabolism, development, and physiology.
  table of contents: Part I. Progress in determining key elements in regulation of gene expression -- 1. Gene regulation in physiological processes -- 2. Epigenetics, the nonprotein coding genome, and human accelerated sequences -- Part II. Evolution and adaptation -- 3. Gene expression and regulation relative to specific tissues and functions -- 4. Evo-Devo and morphological diversity -- 5. Adaptation and evolution -- 6. Adaptations metabolic and genomic to environmental changes -- Part III. Adaptation -- 7. Regulatory elements relevant to brain, connectome, and neurodevelopmental disorders -- 8. Altered gene expression associated with developmental defects and disease 9. Metabolic, epigenetic functions and correlations with phenotype 10. Aging, genomic, mitochondrial, and regulatory changes -- Part IV. Altered gene expression associated with developmental defects and disease -- 11. The regulatory genome and defects in monogenic diseases -- 12. Epigenetics and human disease 13. Connecting developmental defects and evolutionary findings -- 14. The regulatory genome and complex common diseases.
  note: Includes bibliographical references and index.
  subject:
    topic: Genetic regulation
  subject:
    topic: Gene expression
  subject:
    topic: Medical genetics
  subject:
    topic: Gene Expression
  subject:
    topic: Genetics, Medical
  subject:
    topic: Gene Expression Regulation
  subject:
    topic: Régulation génétique
  subject:
    topic: Expression génique
  subject:
    topic: Génétique médicale
  subject:
    topic: Gene expression
  subject:
    topic: Genetic regulation
  subject:
    topic: Medical genetics
  classification: QH450
  classification: 572.865
  related item:
    identifier: (OCoLC)1347696339
  identifier: 9780443153532
  identifier: 0443153531
  identifier: 9780443153525
  identifier: 0443153523
  identifier: 9780443153532 Ingram Content Group
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: YDX
    record creation date: 230320
    record change date: 20260327174133.1
    record identifier: in00005771533
    language of cataloging:
      language term: eng