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Joint and bone : from bench to bedside /

Joint and Bone: From Bench to Bedside, Volume Three, the latest release in the Stem Cell Innovation in Health and Disease series, is a timely and fascinating collection of information and new discoveries that provides a contemporary snapshot album from the fast-moving field of regenerative medicine...

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Bibliographic Details
Corporate Author: ScienceDirect (Online service)
Other Authors: Jiang, Deming (Editor), El-Hashash, Ahmed (Editor)
Format: eBook
Language:English
Published: London : Academic Press, [2023]
Subjects:
Bones > Diseases > Treatment.
Joints > Diseases > Treatment.
Stem cells > Therapeutic use.
Bone remodeling.
Regenerative medicine.
Tissue engineering.
Bone Remodeling
Regenerative Medicine
Stem Cells
Tissue Engineering
Os > Maladies > Traitement.
Articulations > Maladies > Traitement.
Cellules souches > Emploi en thérapeutique.
Os > Remodelage.
Médecine régénératrice.
Génie tissulaire.
Bones > Diseases > Treatment
Joints > Diseases > Treatment
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Front Cover
  • Joint and Bone
  • Copyright Page
  • Dedication
  • Contents
  • List of contributors
  • About the editors
  • Foreword
  • Preface
  • Epigraph
  • Introduction
  • References
  • 1 Cutting edge research on stem cell applications in joint, cartilage, and bone repair and regeneration
  • Abbreviations
  • 1.1 Introduction
  • 1.1.1 Brief structure of joint and bones
  • 1.1.1.1 Joint structure
  • 1.1.1.2 Bone structure, function, and remodeling
  • 1.1.1.2.1 Bone ultrastructure and matrix
  • 1.1.1.2.2 The bone cellular components
  • 1.1.1.2.3 The process of bone remodeling
  • 1.1.2 Advances in stem cell application in joint and cartilage repair and regeneration
  • 1.1.2.1 Stem cell implantation, homing and in situ regeneration strategies
  • 1.1.2.1.1 Exogenous stem cell implantation strategy
  • 1.1.2.1.2 In situ regeneration strategy and stem cell homing
  • 1.1.3 Stem cells in bone repair and regeneration
  • 1.1.3.1 Stem cell differentiation into osteoblasts
  • 1.1.3.2 Stem cell roles in bone repair and regeneration
  • 1.1.3.3 The contributions of stem cells to bone defects and bone/cartilage restoration and regeneration
  • 1.2 Conclusions and future directions
  • References
  • 2 Stem cell-based organoid culture system as an innovative model of osteoarthritis and other joint/bone diseases
  • 2.1 Introduction
  • 2.1.1 Organoid culture system
  • 2.1.2 Bone organoids culture
  • 2.1.3 Woven bone organoids
  • 2.1.4 Bone marrow organoids
  • 2.1.5 Cartilaginous organoids
  • 2.1.6 Callus organoids
  • 2.1.7 Trabecular bone organoids
  • 2.1.8 Organoid-based disease modeling
  • 2.1.9 Osteoarthritis model
  • 2.1.10 Osteoporosis model
  • 2.1.11 Bone defect model
  • 2.1.12 Bone deformities model
  • 2.1.13 Osteomyelitis model
  • 2.1.14 Bone tumor model
  • 2.1.15 Challenges and prospective
  • References.
  • 5 Therapies related to mesenchymal stem cells for cartilage, joint, and bone diseases
  • 5.1 Introduction
  • 5.2 Mesenchymal stem cells
  • 5.3 MSCs for cartilage repair and regeneration
  • 5.3.1 Physiology
  • 5.3.2 Pathology
  • 5.3.3 Clinical treatment
  • 5.3.4 MSCs for treatment of cartilage disease and cartilage regeneration
  • 5.3.5 Clinical trials
  • 5.4 MSCs for tendon/ligament repair
  • 5.4.1 Physiology
  • 5.4.2 Pathology
  • 5.4.3 Clinical treatment
  • 5.4.4 MSCs for the treatment of tendon/ligament disease and tendon/ligament regeneration
  • 5.4.5 Clinical trials
  • 5.5 MSCs for bone regeneration
  • 5.5.1 Physiology
  • 5.5.2 Pathology
  • 5.5.3 Clinical treatment
  • 5.5.4 MSCs for treatment of bone disease and bone regeneration
  • 5.5.5 Clinical trials
  • 5.6 Prospects
  • 5.6.1 MSCs-derived exosomes
  • 5.6.2 MSCs-derived exosomes in cartilage regeneration
  • 5.6.3 MSCs-derived exosomes in tendon/ligament regeneration
  • 5.6.4 MSCs-derived exosomes in bone regeneration
  • 5.6.5 Obstacles related to exosomes in clinical treatment
  • 5.6.6 Selecting functional subpopulations of MSCs
  • 5.7 Conclusion
  • Acknowledgement
  • References
  • 6 Application potentials of the iPSC technology in modeling, drug discovery and regeneration of skeletal system disorders
  • 6.1 Introduction
  • 6.2 Somatic cell reprogramming and iPSC differentiation
  • 6.2.1 Evolving technologies for cell reprogramming
  • 6.2.2 Differentiation of iPSC towards skeletal cell lineages
  • 6.2.2.1 Chondrogenic differentiation of iPSC
  • 6.2.2.2 Differentiation of iPSC towards bone cells
  • 6.2.2.3 iPSC derivation of mesenchymal stem cells
  • 6.3 iPSC application in disease modeling and drug screening
  • 6.3.1 Modeling cartilage diseases with iPSC
  • 6.3.2 Modeling bone diseases with iPSC
  • 6.4 iPSC-based regenerative therapy for orthopedic disorders.
  • 6.4.1 Preclinical and clinical studies of iPSC-derived chondrocytes
  • 6.4.2 iMSC and the application potentials
  • 6.4.3 iMSC-Exos for regenerative repairing of articular cartilage
  • 6.4.4 Gene-edition of iPSC/iMSC to enhance their regenerative properties
  • 6.5 Perspectives and further challenges
  • References
  • 7 Advances in animal models for bone and joint diseases
  • 7.1 Introduction
  • 7.2 Osteoarthritis
  • 7.2.1 General characteristics of osteoarthritis
  • 7.2.1.1 Epidemiology of osteoarthritis
  • 7.2.1.2 Pathogenesis of osteoarthritis
  • 7.2.1.3 Diagnosis of osteoarthritis
  • 7.2.1.4 Treatment of osteoarthritis
  • 7.2.2 Animal models of osteoarthritis
  • 7.2.2.1 Classification of osteoarthritis animal models
  • 7.2.2.2 Spontaneous osteoarthritis models
  • 7.2.2.2.1 Naturally occurring models
  • 7.2.2.2.2 Genetically modified models
  • 7.2.2.3 Induced osteoarthritis models
  • 7.2.2.3.1 Surgically induced models
  • 7.2.2.3.2 Chemically induced models
  • 7.3 Rheumatoid arthritis
  • 7.3.1 General characteristics of rheumatoid arthritis
  • 7.3.1.1 Epidemiology and etiology of rheumatoid arthritis
  • 7.3.1.2 Pathogenesis of rheumatoid arthritis
  • 7.3.1.3 Clinical manifestations of rheumatoid arthritis
  • 7.3.1.4 Treatment of rheumatoid arthritis
  • 7.3.2 Animal models of rheumatoid arthritis
  • 7.3.2.1 Induced rheumatoid arthritis models
  • 7.3.2.1.1 Collagen-induced arthritis models
  • 7.3.2.1.2 Collagen antibody-induced arthritis model
  • 7.3.2.1.3 Zymosan-induced arthritis model
  • 7.3.2.1.4 Antigen-induced arthritis model
  • 7.3.2.1.5 Other induced arthritis models
  • 7.3.2.2 Genetically modified rheumatoid arthritis models
  • 7.3.2.2.1 Human tumor necrosis factor gene mice
  • 7.3.2.2.2 Human/SCID chimeric mice
  • 7.3.2.2.3 Human Dr4-CD4 mice
  • 7.3.2.2.4 Human IL-1ra-/- transgenic mice
  • 7.3.2.2.5 K/B×N model
  • 7.3.2.2.6 SKG model.
  • 7.4 Conclusions
  • References
  • 8 Novel biomaterials for stem cell engineering and bone regeneration
  • 8.1 The role of biomaterials in bone regeneration
  • 8.1.1 Local delivery biomaterials
  • 8.1.1.1 Decellularized extracellular matrix-based biomaterial
  • 8.1.1.2 Inorganic biomaterial
  • 8.1.1.3 Organic hydrogel
  • 8.1.1.4 Injectable material
  • 8.1.2 Systemic delivery biomaterials
  • 8.2 Biomaterials for stem cell delivery in bone regeneration
  • 8.2.1 Scaffold biomaterials for stem cells delivery
  • 8.2.1.1 Decellularized scaffold
  • 8.2.1.2 Natural polymeric materials
  • 8.2.1.3 Synthetic polymeric materials
  • 8.2.2 Hydrogels for stem cell delivery
  • 8.2.2.1 Polysaccharide-based hydrogels
  • 8.2.2.2 Protein/peptide-based hydrogels
  • 8.2.2.3 dECM-based hydrogels
  • 8.2.2.4 Synthetic polymer-based and composite hydrogels
  • 8.2.3 Engineered stem cell delivery
  • 8.3 Biomaterials for stem cell-derived substance delivery in bone regeneration
  • 8.3.1 Therapy based on exosome delivery in bone regeneration
  • 8.3.2 Therapy based on RNA delivery in bone regeneration
  • 8.3.2.1 miRNA-based therapy
  • 8.3.2.2 mRNA-based therapy
  • 8.3.2.3 siRNA-based therapy
  • 8.3.3 Therapy based on other stem cell-derived substances in bone regeneration
  • 8.4 Biomaterials for endogenous stem cell regulation in bone regeneration
  • 8.5 Transformation and limitations of biomaterials for bone regeneration
  • References
  • 9 Stem cell innovation in bone and joint health and diseases: general conclusions, challenges and prospectives
  • 9.1 Roles of stem cells in modeling bone and joint disease
  • 9.2 Stem cell application in the treatment of bone and joint diseases, repair and regeneration
  • References
  • Index
  • Back Cover.