Transcription and translation in health and disease /
Transcription and Translation in Health and Disease provides a detailed overview of the regulators underlying transcription and translation in relation to a variety of human diseases and disorders. Beginning with an introduction into the current perspectives relating to these processes in human dise...
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| Other Authors: | , , |
| Format: | eBook |
| Language: | English |
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London ; San Diego, CA :
Academic Press, an imprint of Elsevier,
[2023]
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| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Intro
- Transcription and Translation in Health and Disease
- Copyright
- Contents
- Contributors
- About the editors
- Preface
- Section I: Introduction
- Chapter 1: Current perspective of transcriptional regulators in human health and diseases
- Introduction
- Key transcriptional regulators and their critical role in regulating the transcription
- Chromatin modifiers
- Histone modifications
- DNA methylation
- N6-methyladenosine (m6A)
- Noncoding RNAs
- Alternative splicing
- Transcription factors
- Super-enhancers
- Dysregulation of transcriptional regulators in diabetes
- Dysregulation of transcriptional regulators in human cancers
- Chromatin regulators
- DNA methylation
- N6-methyladenosine (m6A)
- Noncoding RNAs
- Alternative splicing
- Misregulation of transcription factors (TFs) and mediator coactivation complex
- References
- Section II: Transcriptional and translational regulators in cancer
- Chapter 2: Role of alternative splicing in health and diseases
- Introduction
- Gene expression
- Transcription
- Posttranscriptional changes or RNA processing
- Translation
- Regulation of gene expression
- Splicing and alternative splicing
- Regulation of alternative splicing: Splicing factors
- Technologies to find alternative splicing
- Splicing arrays
- Analysis of AS using microarray
- RNA-sequencing
- Analysis of AS using RNA_Seq
- Alternative splicing in disease
- References
- Chapter 3: Role of transcriptional and posttranscriptional regulation of sphingolipid genes in molecular heterogeneity of ...
- Introduction to sphingolipids
- Breast cancer heterogeneity
- Sphingolipid gene expression in different subtypes of breast cancer
- Molecular mechanisms by which sphingolipids regulate gene expression in signaling cascades
- Posttranscriptional modifications
- References.
- Chapter 7: Regulation of posttranscriptional events by RNA-binding proteins
- Introduction
- Dysregulation of RBPs involved in posttranscriptional regulation
- Nascent mRNA bound proteins in cancer
- Cap-binding proteins in cancer
- Splicing associated proteins in cancer
- Poly(A) tail and alternative polyadenylation-dependent proteins in cancer
- Modified base recognizing proteins in cancer
- mRNPs involved in nuclear export and their role in cancer
- mRNPs involved in subcellular localization and their role in cancer
- mRNPs in translation and cancer
- mRNP stability and cancer
- Conclusions
- Acknowledgment
- References
- Chapter 8: The language of posttranslational modifications and deciphering it from proteomics data
- Introduction
- PTMs in cancer
- PTM cross-talks are prevalent in health and disease
- Positive cross-talk
- Negative PTM cross-talk
- PTMs in drug resistance
- PTMs and SNPs
- Shotgun proteomics for studying proteins and their modifications
- Global proteome analysis by bottom-up shotgun proteomics
- Sample processing for PTM enrichment
- Fragmentation modes for PTM analysis
- Data analysis for PTMs
- Identification of PTMs
- Variable modification search
- Tag-based error tolerant search
- Open modification search
- Multistage search
- Open spectral library search
- Global PTM discovery approaches (G-PTM and G-PTM-D)
- Diagnostic-ion scanning for modification analysis
- DIA methods for modification analysis
- Modification site false discovery rate (FDR) and false localization rate (FLR)
- PTM quantitation techniques
- Functional analysis of protein mod-forms
- Conclusion
- Acknowledgments
- References
- Section III: Transcriptional and translation regulators of other diseases
- Chapter 9: Noncoding RNAs in human health and diseases
- Introduction
- Noncoding RNA.
- Types of noncoding RNA
- Long noncoding RNAs
- MicroRNAs
- Small-interfering RNA
- PIWI-interacting RNA
- Enhancer RNAs
- Circular RNAs
- Role of noncoding RNAs in diseases
- MicroRNAs in diseases
- Small-interfering RNA in diseases
- PIWI-interacting RNA in diseases
- Enhancer RNAs in diseases
- Circular RNAs in diseases
- Role of ncRNAs in diabetes
- Cross-talk between miR-29 and miR-let7 in diabetes-induced kidney fibrosis
- Conclusion
- Perspectives and future directions
- IntroductionMetabolic disorders resulting due to high blood sugar leads to destruction of pancreatic beta cells resulting into
- References
- Chapter 10: MiRNAs as epigenetic regulators for gut microbiome
- Introduction
- MicroRNA discovery and biogenesis
- Gene regulation by miRNAs
- miRNAs in host immune system
- Gut microbiome-As a regulator of wellness and diseases
- Microbiota-miRNA interplay to influence gene expression
- Epithelial cell microRNAs in gut immunity
- Gut microbiome-miRNA And human diseases
- Inflammatory bowel diseases
- Liver diseases
- Cardiovascular diseases
- Neurological disorders
- Human carcinomas
- Concluding comments and future viewpoints
- References
- Chapter 11: Crosstalk between microRNAs and epigenetics during brain development and neurological diseases
- Introduction
- Micro-RNAs
- miRNA genomic sites
- miRNA biogenesis
- Regulation of micro-RNA functions
- Nonconventional ways of miRNA regulation
- Epigenetic changes
- Neural development and miRNAs
- Neural development and epigenetics
- Neurodevelopmental disorders
- Autism spectrum disorder
- Role of miRNAs in autism
- Role of epigenetics in autism
- Cross-talk between miRNAs and epigenetics in autism
- Rett syndrome
- Role of miRNAs in Rett syndrome
- Role of epigenetics in Rett syndrome.