Principles of multiple-liquid separation systems : interaction, application and advancement /

"Principles of Multiple-Liquid Separation Systems: Interaction, Application and Advancement describes the basic principles and advancements of multiple-liquid separation systems in downstream processing. Several important elements are included, such as the fundamental process and mechanisms of...

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Bibliographic Details
Corporate Author:	ScienceDirect (Online service)
Other Authors:	Chew, Kit Wayne (Editor), Chia, Shir Reen (Editor), Show, Pau Loke (Editor)
Format:	eBook
Language:	English
Published:	Amsterdam, Netherlands ; Oxford, United Kingdom ; Cambridge MA : Elsevier, [2023]
Subjects:	Separation (Technology) Liquids. Séparation (Technologie) Liquides. liquid. Liquids Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Front cover
Half title
Title
Copyright
Contents
Contributors
Chapter 1 Polymer-polymer interaction
1.1 Introduction
1.2 Phase diagram
1.3 Parameters influencing phase diagram
1.3.1 Molecular weight
1.3.2 Polymer concentration
1.3.3 Temperature
1.3.4 pH
1.3.5 Tie line length
1.4 Application of aqueous two-phase system
1.4.1 Proteins
1.4.2 Pharmaceutical products
1.4.3 Low molecular weight compounds
1.5 Genetic materials
1.6 Future perspective
1.7 Conclusion
References
Chapter 2 Polymer-salt interaction
2.1 Introduction
2.2 Mechanism and working principles
2.2.1 Binodal curve
2.3 Key process parameters
2.3.1 Effect of polymer molecular weight (MW)
2.3.2 Effect of concentration of polymer
2.3.3 Effect of system pH
2.3.4 Effect of temperature
2.3.5 Effect of hydrophobicity and addition of salt
2.4 Applications
2.4.1 Protein purification
2.4.2 DNA and nucleic acids
2.4.3 Virus, virus-like particles (VLPs)
2.4.4 Drug residues in food and water
2.5 Limitation and future challenges
Conclusion
References
Chapter 3 Alcohol-salt interaction
3.1 Introduction
3.2 Background and basic principle of alcohol/salt-based liquid biphasic system
3.3 Influence of key parameters
3.3.1 Effect of temperature
3.3.2 Effect of anion salt type
3.3.3 Effect of type of alcohol
3.4 Applications of alcohol/salt-based LBS
3.4.1 Enzymes
3.4.2 Proteins
3.4.3 Medicinal plants
3.4.4 Other applications
3.5 Limitations and advancements to the alcohol/salt-based liquid biphasic system
3.6 Conclusions
References
Chapter 4 Sugar-based deep eutectic solvent-aqueous two-phase system
4.1 Introduction
4.2 Sugar-based deep eutectic solvent
4.2.1 Synthesis of deep eutectic solvent.
4.2.2 Characterization of deep eutectic solvent
4.3 Sugar-based deep eutectic solvent-aqueous two-phase system
4.4 Effect of parameters
4.4.1 Mass fraction of deep eutectic solvent
4.4.2 Type of hydrogen bond acceptor and hydrogen bond donor
4.4.3 Hydrogen bond acceptor to hydrogen bond donor mass/molar ratio
4.4.4 Temperature
4.4.5 Type of phase forming component
4.5 Application of sugar-based deep eutectic solvent-aqueous two-phase system
4.6 Advancement of sugar-based deep eutectic solvent-aqueous two-phase system over the last 5 years
4.7 Recycling of sugar-based deep eutectic solvent
4.8 Conclusions
References
Chapter 5 Ionic liquid-salt interaction
5.1 Introduction
5.1.1 Types of ATPS
5.2 Fundamentals of ionic liquid-salt: thermodynamic and properties
5.3 Determination of solution concentration in both phases
5.4 Factors that influence the two-phase separation in ionic liquid/salt ATPS
5.4.1 Effect of type of inorganic salt
5.4.2 Effect of inorganic salt concentration
5.4.3 Effect of temperature
5.5 Applications of Ionic liquid/salt ATPS
5.5.1 Separation and concentration of chloramphenicol using Ionic liquid/salt two-phase flotation system (IL-ATPF )
5.5.2 Extraction of protein using Ionic liquid
5.5.3 Purification of roxithromycin using IL-salt ATPS
5.5.4 Extraction of anthraquinones using ILATPS
5.6 Conclusion
References
Chapter 6 T-butanol-salt three-phase interaction
6.1 Introduction
6.2 Process description
6.2.1 Process overview
6.2.2 About tert-butanol and ammonium sulfate
6.3 Principle of three-phase partitioning
6.4 Application of three-phase systems
6.4.1 Extraction of proteins
6.4.2 Oil extraction
6.4.3 Multimolecule separation
6.4.4 Other molecules
6.5 Future perspectives and challenges
6.6 Conclusion.
10.5.2 Key factors
10.5.3 Advantages and limitations
10.6 Electricity-assisted liquid biphasic system
10.6.1 Mechanism
10.6.2 Key factors
10.6.3 Advantages and limitations
10.7 Microwave-assisted liquid biphasic system
10.7.1 Mechanism
10.7.2 Key factors
10.8 Future prospects
References
Chapter 11 Economical sustainability of multiphase systems
11.1 Economic sustainability
11.1.1 Economic feasibility
11.1.2 Cost-benefit analysis
11.2 Advantages of liquid-liquid separation over conventional method
11.2.1 Water content
11.2.2 Interfacial tension
11.2.3 Energy consumption
11.2.4 Equipment requirement
11.2.5 Solvents
11.3 Three-phase interactions
11.4 Costing in liquid separation system
11.4.1 Technology for liquid separation system
11.4.2 Equipment cost for ATPS liquid separation system
11.4.3 Operating cost
11.4.4 Variable cost
11.4.5 Fixed cost
11.4.6 Plant overhead cost
11.5 Value of end product from biochemical engineering separation
11.6 Cost-benefit analysis of ATPS and conventional separation method
11.7 ATPS process cost/benefits evaluation-polymer-salt interaction
11.7.1 Capital/operating cost for ATPS process
11.7.2 Total revenue for ATPS process
11.7.3 Time value of money
11.7.4 Net present value
11.7.5 Internal rate of return
11.7.6 Break-even analysis
11.8 Conventional protein A affinity chromatography cost/benefits analysis
11.8.1 Capital/operating costs for protein A affinity chromatography
11.8.2 Operating costs for protein A capture process
11.8.3 Total revenue
11.8.4 Net present value
11.8.5 Internal rate of return
11.8.6 Break-even analysis
11.8.7 Comparison of ATPS and protein A chromatography
11.9 Conclusion
References
Chapter 12 Environmental sustainability of multiphase systems.
12.1 Introduction
12.2 Environmental impact caused by conventional extraction method
12.2.1 Air pollution
12.2.2 Water pollution
12.2.3 Soil pollution
12.3 Nonconventional extraction method
12.3.1 Microwave-assisted extraction
12.3.2 Pressurized liquid extraction
12.3.3 Gravity separation
12.3.4 Coalescing separation
12.4 Comparison between alternative extraction methods
12.5 Environmental sustainability-related industrial applications
12.5.1 Purification of natural dye carmine
12.5.2 Ionic liquid as green extraction solvent
12.6 Conclusion
References
Chapter 13 Potential upscaling of multiphase systems
13.1 Introduction
13.2 Chromatography
13.2.1 Introduction to chromatography
13.2.2 Limitation and challenges with chromatography
13.2.3 Cleaning and regeneration
13.2.4 Development and advancement in chromatography
13.2.5 Concluding remarks and future prospects
13.3 Membrane
13.3.1 Introduction to membrane
13.3.2 Issues with membrane
13.3.3 Methods to reduce membrane fouling
13.3.4 Advancement in membrane cleaning
13.3.5 Concluding remarks and future prospects
13.4 Aqueous two-phase system
13.4.1 Introduction to aqueous two-phase system
13.4.2 Limitation and challenges
13.4.3 Factor affecting ATPS
13.4.4 Development and advancement
13.4.5 Concluding remarks and future prospects
13.5 Precipitation
13.5.1 Introduction to precipitation
13.5.2 Limitation and challenges
13.5.3 Factors affecting protein solubility
13.5.4 Development and advancement
13.5.5 Concluding remarks and future prospects
13.6 Conclusion
References
Chapter 14 Integrated systems for multiphase development
14.1 Introduction
14.2 Ultrasonic-assisted extraction
14.2.1 Mechanism/working principle
14.2.2 Key factors/influencing parameters.