http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Principles of multiple-liquid separation systems
interaction, application and advancement
"Principles of Multiple-Liquid Separation Systems: Interaction, Application and Advancement describes the basic principles and advancements of multiple-liquid separation systems in downstream processing. Several important elements are included, such as the fundamental process and mechanisms of the multiple-liquid separation system, key principles of the interaction between different solvents and phase components, applications, and green solvents for the separation system. Furthermore, the book gives insights in commercializing this separation technique to industrial scale and making the process environmentally and economically sustainable. The book also presents constructive critics of this separation technique for both past and the latest findings."--provided by Publisher.
Front cover -- Half title -- Title -- Copyright -- Contents -- Contributors -- Chapter 1 Polymer-polymer interaction -- 1.1 Introduction -- 1.2 Phase diagram -- 1.3 Parameters influencing phase diagram -- 1.3.1 Molecular weight -- 1.3.2 Polymer concentration -- 1.3.3 Temperature -- 1.3.4 pH -- 1.3.5 Tie line length -- 1.4 Application of aqueous two-phase system -- 1.4.1 Proteins -- 1.4.2 Pharmaceutical products -- 1.4.3 Low molecular weight compounds -- 1.5 Genetic materials -- 1.6 Future perspective -- 1.7 Conclusion -- References -- Chapter 2 Polymer-salt interaction -- 2.1 Introduction -- 2.2 Mechanism and working principles -- 2.2.1 Binodal curve -- 2.3 Key process parameters -- 2.3.1 Effect of polymer molecular weight (MW) -- 2.3.2 Effect of concentration of polymer -- 2.3.3 Effect of system pH -- 2.3.4 Effect of temperature -- 2.3.5 Effect of hydrophobicity and addition of salt -- 2.4 Applications -- 2.4.1 Protein purification -- 2.4.2 DNA and nucleic acids -- 2.4.3 Virus, virus-like particles (VLPs) -- 2.4.4 Drug residues in food and water -- 2.5 Limitation and future challenges -- Conclusion -- References -- Chapter 3 Alcohol-salt interaction -- 3.1 Introduction -- 3.2 Background and basic principle of alcohol/salt-based liquid biphasic system -- 3.3 Influence of key parameters -- 3.3.1 Effect of temperature -- 3.3.2 Effect of anion salt type -- 3.3.3 Effect of type of alcohol -- 3.4 Applications of alcohol/salt-based LBS -- 3.4.1 Enzymes -- 3.4.2 Proteins -- 3.4.3 Medicinal plants -- 3.4.4 Other applications -- 3.5 Limitations and advancements to the alcohol/salt-based liquid biphasic system -- 3.6 Conclusions -- References -- Chapter 4 Sugar-based deep eutectic solvent-aqueous two-phase system -- 4.1 Introduction -- 4.2 Sugar-based deep eutectic solvent -- 4.2.1 Synthesis of deep eutectic solvent.
4.2.2 Characterization of deep eutectic solvent -- 4.3 Sugar-based deep eutectic solvent-aqueous two-phase system -- 4.4 Effect of parameters -- 4.4.1 Mass fraction of deep eutectic solvent -- 4.4.2 Type of hydrogen bond acceptor and hydrogen bond donor -- 4.4.3 Hydrogen bond acceptor to hydrogen bond donor mass/molar ratio -- 4.4.4 Temperature -- 4.4.5 Type of phase forming component -- 4.5 Application of sugar-based deep eutectic solvent-aqueous two-phase system -- 4.6 Advancement of sugar-based deep eutectic solvent-aqueous two-phase system over the last 5 years -- 4.7 Recycling of sugar-based deep eutectic solvent -- 4.8 Conclusions -- References -- Chapter 5 Ionic liquid-salt interaction -- 5.1 Introduction -- 5.1.1 Types of ATPS -- 5.2 Fundamentals of ionic liquid-salt: thermodynamic and properties -- 5.3 Determination of solution concentration in both phases -- 5.4 Factors that influence the two-phase separation in ionic liquid/salt ATPS -- 5.4.1 Effect of type of inorganic salt -- 5.4.2 Effect of inorganic salt concentration -- 5.4.3 Effect of temperature -- 5.5 Applications of Ionic liquid/salt ATPS -- 5.5.1 Separation and concentration of chloramphenicol using Ionic liquid/salt two-phase flotation system (IL-ATPF ) -- 5.5.2 Extraction of protein using Ionic liquid -- 5.5.3 Purification of roxithromycin using IL-salt ATPS -- 5.5.4 Extraction of anthraquinones using ILATPS -- 5.6 Conclusion -- References -- Chapter 6 T-butanol-salt three-phase interaction -- 6.1 Introduction -- 6.2 Process description -- 6.2.1 Process overview -- 6.2.2 About tert-butanol and ammonium sulfate -- 6.3 Principle of three-phase partitioning -- 6.4 Application of three-phase systems -- 6.4.1 Extraction of proteins -- 6.4.2 Oil extraction -- 6.4.3 Multimolecule separation -- 6.4.4 Other molecules -- 6.5 Future perspectives and challenges -- 6.6 Conclusion.
10.5.2 Key factors -- 10.5.3 Advantages and limitations -- 10.6 Electricity-assisted liquid biphasic system -- 10.6.1 Mechanism -- 10.6.2 Key factors -- 10.6.3 Advantages and limitations -- 10.7 Microwave-assisted liquid biphasic system -- 10.7.1 Mechanism -- 10.7.2 Key factors -- 10.8 Future prospects -- References -- Chapter 11 Economical sustainability of multiphase systems -- 11.1 Economic sustainability -- 11.1.1 Economic feasibility -- 11.1.2 Cost-benefit analysis -- 11.2 Advantages of liquid-liquid separation over conventional method -- 11.2.1 Water content -- 11.2.2 Interfacial tension -- 11.2.3 Energy consumption -- 11.2.4 Equipment requirement -- 11.2.5 Solvents -- 11.3 Three-phase interactions -- 11.4 Costing in liquid separation system -- 11.4.1 Technology for liquid separation system -- 11.4.2 Equipment cost for ATPS liquid separation system -- 11.4.3 Operating cost -- 11.4.4 Variable cost -- 11.4.5 Fixed cost -- 11.4.6 Plant overhead cost -- 11.5 Value of end product from biochemical engineering separation -- 11.6 Cost-benefit analysis of ATPS and conventional separation method -- 11.7 ATPS process cost/benefits evaluation-polymer-salt interaction -- 11.7.1 Capital/operating cost for ATPS process -- 11.7.2 Total revenue for ATPS process -- 11.7.3 Time value of money -- 11.7.4 Net present value -- 11.7.5 Internal rate of return -- 11.7.6 Break-even analysis -- 11.8 Conventional protein A affinity chromatography cost/benefits analysis -- 11.8.1 Capital/operating costs for protein A affinity chromatography -- 11.8.2 Operating costs for protein A capture process -- 11.8.3 Total revenue -- 11.8.4 Net present value -- 11.8.5 Internal rate of return -- 11.8.6 Break-even analysis -- 11.8.7 Comparison of ATPS and protein A chromatography -- 11.9 Conclusion -- References -- Chapter 12 Environmental sustainability of multiphase systems.
12.1 Introduction -- 12.2 Environmental impact caused by conventional extraction method -- 12.2.1 Air pollution -- 12.2.2 Water pollution -- 12.2.3 Soil pollution -- 12.3 Nonconventional extraction method -- 12.3.1 Microwave-assisted extraction -- 12.3.2 Pressurized liquid extraction -- 12.3.3 Gravity separation -- 12.3.4 Coalescing separation -- 12.4 Comparison between alternative extraction methods -- 12.5 Environmental sustainability-related industrial applications -- 12.5.1 Purification of natural dye carmine -- 12.5.2 Ionic liquid as green extraction solvent -- 12.6 Conclusion -- References -- Chapter 13 Potential upscaling of multiphase systems -- 13.1 Introduction -- 13.2 Chromatography -- 13.2.1 Introduction to chromatography -- 13.2.2 Limitation and challenges with chromatography -- 13.2.3 Cleaning and regeneration -- 13.2.4 Development and advancement in chromatography -- 13.2.5 Concluding remarks and future prospects -- 13.3 Membrane -- 13.3.1 Introduction to membrane -- 13.3.2 Issues with membrane -- 13.3.3 Methods to reduce membrane fouling -- 13.3.4 Advancement in membrane cleaning -- 13.3.5 Concluding remarks and future prospects -- 13.4 Aqueous two-phase system -- 13.4.1 Introduction to aqueous two-phase system -- 13.4.2 Limitation and challenges -- 13.4.3 Factor affecting ATPS -- 13.4.4 Development and advancement -- 13.4.5 Concluding remarks and future prospects -- 13.5 Precipitation -- 13.5.1 Introduction to precipitation -- 13.5.2 Limitation and challenges -- 13.5.3 Factors affecting protein solubility -- 13.5.4 Development and advancement -- 13.5.5 Concluding remarks and future prospects -- 13.6 Conclusion -- References -- Chapter 14 Integrated systems for multiphase development -- 14.1 Introduction -- 14.2 Ultrasonic-assisted extraction -- 14.2.1 Mechanism/working principle -- 14.2.2 Key factors/influencing parameters.
edited by Kit Wayne Chew, Shir Reen Chia, Pau Loke Show.
Includes bibliographical references and index.