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Advanced technologies and polymer materials for surgical sutures /

Polymeric materials offer a high level of versatility due to the range of applications possible within the biomedical and clinical fields - including wound closure - particularly in comparison to metals or ceramics. These specialised materials also allow for a diverse array of therapeutic effects. A...

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Bibliographic Details
Corporate Author: ScienceDirect (Online service)
Other Authors: Thomas, Sabu (Editor), Coates, P. D. (Phil D.) (Editor), Whiteside, Ben (Editor), Joseph, Blessy (Editor), Nair, Karthik (Editor)
Format: eBook
Language:English
Published: Cambridge, MA : Woodhead Publishing, an imprint of Elsevier, [2023]
Series:Woodhead Publishing series in biomaterials.
Subjects:
Sutures > Materials > Technological innovations.
Polymers in medicine.
Suturing > Instruments.
Sutures
Polymers > therapeutic use
Sutures (Chirurgie) > Matériaux > Innovations.
Polymères en médecine.
Suture > Instruments.
Materials
Polymers in medicine
Angola
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Front Cover
  • ADVANCED TECHNOLOGIES AND POLYMER MATERIALS FOR SURGICAL SUTURES
  • ADVANCED TECHNOLOGIES AND POLYMER MATERIALS FOR SURGICAL SUTURES
  • Copyright
  • Contents
  • Contributors
  • 1
  • Advances in biopolymer based surgical sutures
  • 1.1 Introduction
  • 1.2 Polymers as suture materials
  • 1.3 Biopolymers
  • 1.4 Biopolymers for sutures
  • 1.4.1 Collagen
  • 1.4.2 Polylactic acid (PLA)
  • 1.4.3 Silk
  • 1.4.4 Chitin &amp
  • chitosan
  • 1.4.5 Polyhydroxyalkanoate (PHA)
  • 1.4.6 Cellulose
  • 1.5 Sterilization of sutures
  • 1.6 Conclusion and future perspectives
  • References
  • 2
  • Functionalization of sutures
  • 2.1 Introduction
  • 2.2 Suture materials: from hairs to antibacterial biopolymers
  • 2.3 Suture types
  • 2.4 Biocompatibility studies for functionalized sutures
  • 2.5 Functionalization
  • 2.5.1 Coating in fibers
  • 2.5.1.1 Dip-coating
  • 2.5.1.2 Electrodeposition
  • 2.5.2 Grafted sutures
  • 2.5.2.1 Monomer
  • 2.5.2.2 Solvent
  • 2.5.2.3 Temperature of reaction
  • 2.5.3 Stimuli-responsive polymers on sutures
  • 2.6 Functionalization of nonabsorbable sutures
  • 2.6.1 Polypropylene sutures
  • 2.6.1.1 Functionalization with azoles
  • 2.6.1.2 Functionalization with Ag
  • 2.6.2 Modified silk sutures
  • 2.7 Functionalization of absorbable sutures
  • 2.7.1 Functionalization with silver
  • 2.7.2 Chitin sutures
  • 2.7.3 Caprolactam sutures gentamicin/silver loaded
  • 2.7.4 Drug-loading on absorbable sutures
  • 2.8 Conclusions
  • Acknowledgments
  • References
  • 3
  • Improving the therapeutic value of sutures
  • 3.1 Content
  • 3.2 General concepts
  • 3.2.1 History of sutures
  • 3.2.2 Characteristics and classification of sutures
  • 3.2.3 Characteristics of commercial sutures
  • 3.3 Suture modification: bioactive devices as the future of the suture technology
  • 3.3.1 Structural modification
  • 3.3.1.1 Fiber dimensions.
  • 3.3.1.2 Topography and microstructure of the suture
  • 3.3.2 Chemical modification
  • 3.3.2.1 Antimicrobial sutures
  • 3.3.2.2 Incorporation of antimicrobial agents in sutures
  • 3.3.2.3 Surface incorporation of antimicrobial agents in sutures
  • 3.3.3 Drug delivery sutures
  • 3.3.4 Stimuli responsive systems
  • 3.3.4.1 pH-responsive polymers
  • 3.3.4.2 Thermo-responsive polymers
  • 3.3.4.3 Stimuli responsive sutures
  • 3.4 Conclusion
  • Acknowledgments
  • References
  • 4
  • Evaluating the mechanical properties of sutures
  • 4.1 Introduction
  • 4.2 Mechanical properties
  • 4.2.1 Tensile strength
  • 4.2.2 Knot strength
  • 4.2.3 Breaking strength
  • 4.2.4 Knot-pull tensile strength
  • 4.2.5 Wound breaking strength
  • 4.2.6 Elasticity
  • 4.2.7 Plasticity
  • 4.2.8 Memory
  • 4.2.9 Pliability
  • 4.2.10 Capillarity
  • 4.2.11 Abrasion
  • 4.3 Characterization techniques
  • 4.3.1 Universal testing machine (UTM)
  • 4.3.2 Abrasive testing
  • 4.4 Effect of antibacterial coating on mechanical properties
  • 4.5 Conclusion
  • References
  • 5
  • Polymers for surgical sutures
  • 5.1 Introduction
  • 5.2 Types of polymeric surgical sutures and their applications
  • 5.2.1 Natural polymers
  • 5.2.1.1 Gut
  • 5.2.1.2 Silk
  • 5.2.2 Synthetic and absorbable polymers
  • 5.2.2.1 PGA-PCL blend
  • 5.2.2.2 PGA-PLA blend
  • 5.2.2.3 P4HB
  • 5.2.2.4 PDS
  • 5.2.3 Synthetic and nonabsorbable polymers
  • 5.2.3.1 Nylon
  • 5.2.3.2 PP
  • 5.2.3.3 PET
  • 5.2.3.4 Polybutester
  • 5.2.3.5 PVDF and PTFE
  • 5.3 Tissue adhesive polymers as suture candidate
  • 5.4 Challenges with current technologies
  • 5.4.1 Bioactive sutures
  • 5.4.2 Smart sutures
  • 5.4.3 Biomimetic sutures
  • 5.4.4 Translation of basic discoveries in clinical applications
  • 5.5 Future perspective and remarks
  • 5.6 Conclusion
  • Acknowledgments
  • References
  • 6
  • Smart sutures
  • 6.1 Introduction.
  • 6.2 Base material of smart suture
  • 6.2.1 Paper
  • 6.2.2 Polyglycerol sebacate
  • 6.2.3 Polycaprolactone
  • 6.2.4 PCL/PGS blend
  • 6.2.5 Cotton
  • 6.2.6 Carbon nanotubes
  • 6.2.7 Wicking
  • 6.2.8 Polyurethane
  • 6.3 Temperature sensors for smart sutures
  • 6.4 pH sensor smart sutures
  • 6.5 Strain smart sutures
  • 6.6 Glucose smart sutures
  • 6.7 Microfluidic analysis smart sutures
  • 6.8 Resorbable smart sutures
  • 6.9 Future smart sutures
  • 6.9.1 Bacterial detection sensors
  • 6.9.2 Neutrophil sensor
  • 6.9.3 Colorimetric smart sutures
  • 6.10 Conclusions
  • References
  • 7
  • Bioactive sutures: advances in surgical suture functionalization
  • 7.1 Introduction
  • 7.2 Suture structure
  • 7.2.1 Absorbable sutures
  • 7.2.2 Nonabsorbable sutures
  • 7.2.3 Monofilament sutures
  • 7.2.4 Multifilament sutures
  • 7.3 Fabricating bioactive suture methods
  • 7.3.1 Fiber level
  • 7.3.2 Cell and gene activators
  • 7.3.3 Stimuli responsive
  • 7.3.4 Researched bioactive suture
  • 7.4 Cell based bioactive sutures
  • 7.4.1 Stem cells
  • 7.4.2 Stem cells for wound healing
  • 7.4.3 Stem cells
  • cardiovascular application
  • 7.4.4 Stem cells
  • tendon repair
  • 7.4.5 Stem cell suture conclusions
  • 7.4.6 mRNA suture
  • 7.4.7 Gene regulation
  • 7.4.8 Growth factor bioactive suture
  • 7.5 Incorporated bioactive material
  • 7.5.1 Chitin bioactive sutures
  • 7.5.2 Bioactive glass for antibacterial sutures
  • 7.6 Future developments of bioactive sutures
  • 7.6.1 Surface architecture sutures
  • 7.7 Conclusion
  • References
  • 8
  • Engineering aspects of suture fabrication
  • 8.1 Introduction
  • 8.1.1 Surgical sutures
  • 8.1.2 The association of surgical sutures with wound healing cascade
  • 8.2 Why is the engineering of suture fabrication important?
  • 8.2.1 Suture design parameters
  • 8.2.1.1 Structural attributes
  • 8.2.1.1.1 Suture size.
  • 9.4 Properties of suture materials: comparative analysis
  • 9.4.1 Physico-mechanical properties
  • 9.4.2 Biological properties
  • 9.5 Micro and nanotechnology-enabled suture materials
  • 9.6 Conclusions and future outlook
  • References
  • 10
  • Suture materials, emerging trends
  • 10.1 Introduction
  • 10.2 Taxonomy of sutures
  • 10.3 Absorbable and nonabsorbable suture materials
  • 10.4 Monofilament, multifilament sutures and barbed sutures brands
  • 10.5 Categories of absorbable sutures
  • 10.5.1 Catgut sutures
  • 10.5.2 Chromic gut sutures
  • 10.5.3 Polyglycolic acid sutures
  • 10.5.4 Polydioxanone sutures
  • 10.5.5 Poliglecaprone sutures
  • 10.5.6 Polyglactin sutures
  • 10.6 Slowly absorbable sutures
  • 10.6.1 Polydioxanone (PDS II)
  • 10.6.2 Polyglyconate (Maxon)
  • 10.6.3 Nonabsorbable sutures
  • 10.6.4 Silk suture
  • 10.6.5 Polymerized caprolactum suture (Supramid)
  • 10.6.6 Polyester suture (Mersilene, Ethibond)
  • 10.6.7 Nylon (Dermalon or Ethilon)
  • 10.6.8 Polybutester (Novafil)
  • 10.6.9 Polypropylene (Prolene)
  • 10.6.10 Structurally coated and un-coated sutures
  • 10.6.10.1 Coated sutures include
  • 10.6.10.2 Un-coated sutures include
  • 10.6.11 Application-based suture categories
  • 10.7 New trends in sutures
  • 10.7.1 Knotless barbed sutures
  • 10.7.2 Antibacterial sutures
  • 10.7.3 Stem cell seeded suture
  • 10.7.4 Smart sutures: electronic/elastic sutures
  • 10.8 Conclusion
  • References
  • Further reading
  • 11
  • Biocompatibility and cytotoxicity of polymer sutures
  • 11.1 Introduction
  • 11.2 Classification of sutures
  • 11.2.1 Origin based classification
  • 11.2.2 Material based classification
  • 11.2.3 Classification based on size
  • 11.2.4 Classification based on physical configuration
  • 11.3 Necessary characteristics of suture materials
  • 11.3.1 Physical and mechanical properties
  • 11.3.2 Handling properties.