Biomedical applications of inorganic photochemistry /

Biomedical Applications of Inorganic Photochemistry, Volume 80 in the Advances in Inorganic Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

Bibliographic Details
Corporate Author:	ScienceDirect (Online service)
Other Authors:	Ford, Peter C., Eldik, Rudi van
Format:	eBook
Language:	English
Published:	[S.l.] : Academic Press, 2022.
Series:	Advances in inorganic chemistry ; v. 80.
Subjects:	Photochemistry. Photochimie. Photochemistry Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Intro
Biomedical Applications of Inorganic Photochemistry
Copyright
Contents
Contributors
Preface
Chapter One: Leveraging the photophysical properties of rhenium(I) tricarbonyl complexes for biomedical applications
1. Introduction
2. Properties and applications of Re(CO)3 complexes
3. Re(CO)3 complexes as photoluminescent imaging agents
4. Simple diimine Re(CO)3 complexes exhibit anticancer activity
5. Pyridylimine Re(CO)3 complexes
6. Isonitrile-containing Re(CO)3 complexes
7. Photoactivation of Re(CO)3 anticancer agents
8. Conclusions and future outlook
Acknowledgments
References
Chapter Two: Strategic design of photofunctional transition metal complexes for cancer diagnosis and therapy
1. Introduction
2. Transition metal complexes for targeted cancer diagnosis and therapy
2.1. Glucose transporters
2.2. Biotin receptors
2.3. Integrins
2.4. G-Protein-coupled receptors
2.5. Epidermal growth factor receptor
2.6. Carbonic anhydrase
2.7. Cyclooxygenase
2.8. Sialylated glycoproteins and glycolipids
3. Activatable transition metal complexes for cancer diagnosis and therapy
3.1. Hypoxia
3.2. pH
3.3. Polarity
3.4. Viscosity
3.5. Redox status
3.6. Enzymes
3.7. Mismatched DNA molecules
3.8. Bioorthogonal chemical reporters
4. Conclusions and future perspective
Acknowledgments
References
Chapter Three: Advances in the design of photoactivated platinum anticancer complexes
1. Introduction
2. Discovery of photoactive Pt(IV) anticancer complexes
3. Mechanism of action
3.1. Radical and ROS generation
3.2. DNA as a target
3.3. Peptide and protein targets
3.4. Induction of immunogenic cell death
4. Axial derivatives of Pt(IV) complexes
4.1. Targeting vectors
4.2. Multi-action derivatives
5. Pt(IV) azide-acetylene derivatives via ``click ́́reactions
6. Nanocarriers
6.1. Proteins
6.2. Polysaccharides
6.3. Hydrogels
6.4. Block copolymers
6.5. Polymetallodrugs
6.6. Carbon dots
6.7. Up-converting nanoparticles (UCNPs)
6.8. Summary and prospects
Acknowledgments
References
Chapter Four: Adventures in the photo-uncaging of small molecule bioregulators
1. Introduction
2. PhotoNORMs and PhotoCORMs
2.1. Uncaging nitric oxide
2.2. Uncaging carbon monoxide
3. Enhancing photoreaction SMB release rates with antennas
3.1. Organic chromophore antennas
3.2. Semiconductor quantum dot antennas
4. Moving toward the phototherapeutic window
4.1. Single photon excitation strategies
4.2. Simultaneous two photon excitation
4.3. Upconverting nanoparticles
4.4. Nano-carriers
5. Biological targeting
5.1. Liposomes
5.2. Hollow gold nanoshells
5.3. Macrophage Trojan Horses
6. Summary
Acknowledgments
References