Neuroimaging in Parkinson's disease and related disorders /
"Neuroimaging in Parkinson's Disease and Related Disorders discusses the advances of molecular, structural and functional neuroimaging techniques associated with the etiology, pathophysiology, effects and complications of novel therapies in Parkinson's and related disorders. With new...
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| Other Authors: | , , |
| Format: | eBook |
| Language: | English |
| Published: |
London, United Kingdom ; San Diego, CA, United States :
Academic Press, an imprint of Elsevier,
[2023]
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| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Front Cover
- NEUROIMAGING IN PARKINSON'S DISEASE AND RELATED DISORDERS
- NEUROIMAGING IN PARKINSON'S DISEASE AND RELATED DISORDERS
- Copyright
- Contents
- Contributors
- Preface
- I
- Introduction
- 1
- Parkinson's disease and related disorders: the pursuit for reliable readouts and the role of neuroimaging
- Introduction
- Clinical aspects of movement disorders
- Hypokinetic movement disorders
- Hyperkinetic movement disorders
- Dystonia
- Restless legs syndrome
- The future of neuroimaging and the application of robust measures in clinical trials
- Conclusion
- References
- 2
- Advances in magnetic resonance imaging
- Introduction
- Basic MRI physics
- T1, T2, and T2∗ relaxation
- Free induction decay
- MRI scanner hardware
- The magnet
- Radiofrequency coils
- Gradient coils
- Shim coils
- Image acquisition
- Spin echo and gradient echo
- Spatial localization gradients
- Inversion recovery
- Image reconstruction
- Echoplanar imaging and turbo spin echo
- Parallel imaging
- MRI modalities
- T1-weighted MR imaging
- T2-weighted MR imaging
- Diffusion-weighted imaging
- Functional MRI
- Arterial spin labeling
- Neuromelanin-sensitive MRI
- Susceptibility-weighted imaging
- Quantitative susceptibility mapping
- Magnetic resonance spectroscopy
- Conclusion
- References
- 3
- Advances in molecular neuroimaging methodology
- Introduction
- PET acquisition
- Quantitative PET analysis
- Kinetic modeling analysis
- Parametric modeling
- Standardized uptake value
- Partial volume correction
- Advanced analysis methodology
- Conclusion
- References
- II
- Clinical applications in Parkinson's disease
- 4
- Dopaminergic molecular imaging in familial and idiopathic Parkinson's disease
- Introduction
- Molecular biology and imaging of the dopaminergic system.
- Molecular imaging of the presynaptic dopaminergic terminals
- Molecular imaging of the amino l-acid decarboxylase
- Molecular imaging of the dopamine transporter
- Molecular imaging of the vesicular Monoamine Transporter 2
- Combined study of the AADC, DAT, and VMAT2 enzyme in idiopathic and familial PD
- Molecular imaging of the postsynaptic dopaminergic terminals
- Molecular imaging of the D1 receptors
- Molecular imaging of the D2 receptors
- Molecular imaging of the D3 receptors
- Conclusive remarks
- References
- 5
- Serotonergic molecular imaging in familial and idiopathic PD
- Introduction
- Serotonergic system changes in Parkinson's disease
- Molecular imaging of serotonergic system
- Serotonergic molecular imaging of motor symptoms
- Serotonergic molecular imaging of nonmotor symptoms
- Serotonergic molecular imaging of prodromal stages of Parkinson's disease
- Conclusions
- References
- 6
- Molecular imaging beyond dopamine and serotonin in familial and idiopathic Parkinson's disease
- Introduction
- Glucose metabolism
- Synaptic pathology
- Neurotransmitter systems
- Cannabinoid
- Cholinergic
- Opioid
- Noradrenergic
- Glutamatergic
- Phosphodiesterase
- Neuroinflammation
- Protein aggregation
- Energy dysregulation
- Conclusion
- References
- 7
- Structural MRI in familial and idiopathic PD
- Introduction
- Structural volumetric MRI
- Gray matter volumes in idiopathic Parkinson's disease
- Association between gray matter changes with idiopathic Parkinson's disease motor symptoms
- Correlation between gray matter changes with nonmotor symptoms
- Cortical thickness
- Structural MRI changes in familial Parkinson's disease
- Diffusion MRI studies in idiopathic Parkinson's disease
- Free-water MRI changes in idiopathic Parkinson's disease.
- Diffusion MRI changes and nonmotor symptoms of idiopathic Parkinson's disease
- Diffusion MRI changes associated with cognitive impairment in idiopathic Parkinson's disease
- Diffusion MRI changes within the glymphatic system in idiopathic Parkinson's disease
- Diffusion tensor imaging in familial Parkinson's disease
- Neuromelanin-sensitive MRI in idiopathic Parkinson's disease
- Neuromelanin-sensitive MRI in familial Parkinson's disease
- Iron-sensitive MRI studies in idiopathic Parkinson's disease
- Iron-sensitive MRI studies in familial Parkinson's disease
- Arterial spin labeling in idiopathic Parkinson's disease
- Summary
- References
- 8
- Functional MRI in familial and idiopathic PD
- Introduction
- rs-fMRI of motor symptoms in idiopathic Parkinson's disease
- As PD progresses, different FC changes in the brain can occur: multiple cross-sectional and longitudinal studies
- rs-fMRI of non-motor symptoms in idiopathic Parkinson's disease
- rs-fMRI studies in familial Parkinson's disease
- Task-based fMRI
- Motor tb-fMRI in idiopathic Parkinson's disease patients
- Motor skill learning
- Cognitive tb-fMRI in idiopathic Parkinson's disease patients
- tb-fMRI studies in familial Parkinson's disease
- Conclusions
- References
- 9
- Molecular imaging in prodromal Parkinson's disease
- Introduction
- Definition of prodromal Parkinson's disease
- Dopaminergic imaging of prodromal Parkinsonism
- Molecular imaging of brain metabolism in prodromal Parkinson's disease
- Serotonergic molecular imaging of prodromal Parkinson's disease
- Molecular imaging of other neurotransmettitorial systems in prodromal Parkinson's disease
- Conclusions
- References
- III
- Clinical applications in lewy body dementias
- 10
- Molecular imaging evidence in favor or against PDD and DLB overlap
- Introduction.
- Functional magnetic resonance imaging
- Single-photon emission computed tomography
- Positron emission tomography
- Brain metabolism
- Dopaminergic system
- Microglial activation
- Cholinergic system
- Tau deposition
- Synaptic pathology
- Conclusion and future directions
- References
- V
- Clinical applications in other movement disorders
- 15
- Molecular imaging in Huntington's disease
- Introduction
- Brain metabolism
- Dopaminergic system
- Neuroinflammation
- Phosphodiesterases
- Opioidergic system
- GABAergic system
- Cannabinoid system
- Adenosinergic system
- Synaptic pathology
- Use of molecular imaging to track disease progression in Huntington's disease
- Use of molecular imaging as outcome measure in Huntington's disease trials
- Future perspectives of molecular imaging in Huntington's disease
- References
- 16
- Magnetic resonance imaging in Huntington's disease
- Introduction
- Structural MRI markers of disease pathology in Huntington's disease
- Volumetric MRI
- Diffusion tensor imaging
- Magnetization transfer imaging
- Functional MRI markers of disease pathology in Huntington's disease
- Resting-state fMRI
- Task-based fMRI
- Arterial spin labeling
- Iron
- Magnetic resonance spectroscopy
- The use of MRI to track disease progression in Huntington's disease
- Macrostructural MRI measures
- Microstructural MRI measures
- Functional MRI measures
- Magnetic resonance spectroscopy
- The use of MRI as outcome measures and for stratification in Huntington's disease trials
- Conclusion
- References
- 17
- Neuroimaging in essential tremor
- Introduction
- MRI markers of essential tremor
- Structural MRI
- Volumetric MRI
- Cortical thickness
- Diffusion tensor imaging
- Iron-sensitive MRI
- Neuromelanin MRI
- Functional MRI
- Task-based fMRI
- Resting-state fMRI.