Mitochondrial intoxication /

Mitochondrial Intoxication explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications a...

Full description

Bibliographic Details
Corporate Author:	ScienceDirect (Online service)
Other Authors:	Roberto de Oliveira, Marcos
Format:	eBook
Language:	English
Published:	[S.l.] : Academic Press, 2023.
Subjects:	Mitochondrial pathology. Toxins > Health aspects. Mitochondria > pathology Xenobiotics > toxicity Maladies mitochondriales. Mitochondrial pathology Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Intro
Mitochondrial Intoxication
Copyright
Dedication
Contents
Contributors
Preface
Acknowledgments
Chapter 1: Mitochondrial physiology: An overview
1. Introduction
2. TCA cycle and oxidative phosphorylation system activity
3. Mitochondrial dynamics: Fusion and fission
3.1. Mitochondrial fusion
3.2. Mitochondrial fission
4. Mitochondrial biogenesis and mitophagy
4.1. Regulation of mitochondrial biogenesis
4.2. Mitophagy: Molecular mechanisms
4.3. Mitochondrial homeostasis: Coordination of mitochondrial biogenesis and mitophagy
4.4. Physiological functions of biogenesis and mitophagy
5. Mitochondria-related cell death
5.1. Mitochondrial role in apoptosis
5.2. Mitochondria in pyroptosis, necroptosis, and ferroptosis
6. Mitochondrial redox biology
6.1. Superoxide dismutase
6.2. Mitochondrial catalase and oxidative injury
6.3. Mitochondrial NADPH and redox homeostasis
6.4. Mitochondrial glutathione
7. Concluding remarks
References
Chapter 2: Molecular markers of mitochondrial intoxication
1. Mechanisms of interaction leading to mitochondrial injury
2. Markers of mitochondrial damage
2.1. ROS/RNS production by mitochondria
2.2. Protein nitration
2.3. Protein carbonylation
2.4. Lipid peroxidation
2.5. MMP loss
2.6. Opening of the MPT and apoptosis
2.7. Calcium metabolism dyshomeostasis
2.8. Damage to mitochondrial DNA
2.9. Bioenergetics failure
3. Chemical-induced mitochondrial damage: Case examples
3.1. Interference in membrane structure and functions
3.2. Inhibition and uncoupling of oxidative phosphorylation
3.3. Alteration of the calcium homeostasis
3.4. Complexation with biomolecules
4. Conclusions
References
Chapter 3: Drug-induced mitochondrial impairment: Mechanisms and testing systems.
1. Introduction
2. Mechanisms of drug-induced mitochondrial impairment
2.1. Changes in mitochondrial membrane composition and integrity
2.2. The inhibition of mitochondrial respiratory chain components
2.3. Mitochondrial permeabilization
2.4. Mitochondrial DNA damage
2.5. Effects of drugs on the uptake of molecules required for mitochondrial function
2.6. Drugs with protonophoretic and oxidative phosphorylation uncoupling activity
3. Testing systems for evaluating drug-induced mitochondrial impairment
4. Biomarkers of drug-induced mitochondrial injury in clinical settings
5. Protective strategies against drug-induced mitochondrial dysfunction
6. Outlook
Conflicts of interest
References
Chapter 4: Clinical consequences of drug-induced mitochondrial dysfunction
Abbreviations
1. Introduction
2. Clinical manifestations of drug-induced mitochondrial dysfunction
2.1. Hepatotoxicity
2.1.1. Steatosis
2.1.1.1. Mitochondrial involvement
2.1.1.2. Clinical examples
2.1.2. Acute liver failure
2.1.2.1. Mitochondrial involvement
2.1.2.2. Clinical examples
2.2. Skeletal muscle toxicity
2.2.1. Mitochondrial involvement
2.2.2. Clinical examples
2.3. Cardiotoxicity
2.3.1. Mitochondrial involvement
2.3.2. Clinical examples
2.4. Neuropathy
2.4.1. Mitochondrial involvement
2.4.2. Clinical examples
2.5. Nephrotoxicity
2.5.1. Mitochondrial involvement
2.5.2. Clinical examples
2.6. Ototoxicity
2.6.1. Mitochondrial involvement
2.6.2. Clinical examples
3. Interindividual variation
4. Concluding remarks
References
Chapter 5: Challenges in mitochondrial profiling during pre-clinical studies
Abbreviations and formulae
1. Introduction
1.1. Introduction to mitochondrial toxicology
1.2. Main roles of mitochondria.
2. Biotransformation of AFB1
3. AFB1 toxicity of the mitochondria
3.1. AFB1 toxicity in the mitochondria: Lipids
3.2. AFB1 toxicity in the mitochondria: Membrane potential and permeability
3.3. AFB1 toxicity in the mitochondria: Oxidative stress and apoptosis
3.4. AFB1 toxicity in the mitochondria: Respiratory chain enzymes
4. Conclusion
References
Chapter 9: The effects of alcohol abuse against the mitochondria: Functional consequences for liver, muscle, and the brain
1. Introduction
2. Alcohol toxicity
2.1. Alcohol consumption in our current society
2.2. Types of alcohol consumption
3. Alcohol consumption affects mitochondrial function
3.1. Alcohol impairs mitochondria in the liver
3.2. Alcohol impairs mitochondrial health in muscle cells
3.3. Association of alcohol consumption with brain abnormalities
4. Strategies to reduce mitochondrial injury induced by alcohol
4.1. Enhancing mitochondrial function to reduce alcohol-induced liver disease
4.2. Reversing mitochondria injury to reduce muscle disease induced by alcohol
4.3. Activation of melanocortin system and Nrf2 antioxidant pathway to reduce brain mitochondrial dysfunction induced by ...
5. Conclusions
Acknowledgments
References
Further reading
Chapter 10: The effect of aluminum on mitochondrial dysfunctions
1. Introduction
2. Aluminum and human exposure
3. Aluminum toxicokinetic
4. Basic mechanism of action of aluminum
5. Mitochondrion as a target organelle for Al toxicity
5.1. Production of aluminum-superoxide anion complexes in the mitochondrial matrix
5.2. Oxidative environment leads to lipid peroxidation of mitochondrial membranes
5.3. Disturbance in the activity of antioxidant enzymes after aluminum exposure
5.4. Disruption of mitochondrial energy metabolism mediated by aluminum.