Cover Image

Biomedical defense principles to counter DNA deep hacking /

The book covers the use of tools such as CRISPR for malicious purposes, which has led agencies such as the U.S. Office of the Director of National Intelligence to add gene editing to its annual list of threats posed by weapons of mass destruction and proliferation. --

Bibliographic Details
Main Author: Termanini, Rocky
Corporate Author: ScienceDirect (Online service)
Format: eBook
Language:English
Published: London : Academic Press, 2023.
Subjects:
Medical informatics > Security measures.
DNA data banks > Security measures.
Médecine > Informatique > Sécurité > Mesures.
Banques de données génétiques (Génétique légale) > Sécurité > Mesures.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Front Cover
  • Biomedical Defense Principles to Counter DNA Deep Hacking
  • Biomedical Defense Principles to Counter DNA Deep Hacking
  • Copyright
  • Dedication
  • Contents
  • About the Author
  • Acknowledgment
  • 1
  • The miraculous architecture of the gene pyramid
  • My name is DNA
  • Initial thoughts
  • Anatomy of DNA
  • Watson and crick story
  • DNA double helix
  • What is a gene?
  • What is the chromosome?
  • Chromosomes in forensics
  • The central dogma
  • Proteins
  • Amino acid
  • RNA structure
  • Transcription (phase-1 of central dogma)
  • The transcription process
  • Translation (phase-2 of central dogma) process
  • Anatomy of CRISPR machine
  • CRISPR structure
  • Drawbacks and unethical issues
  • Bio-hacking CRISPR, cracking the biological atom
  • CRISPR cyber hacking
  • Appendix
  • Appendix-A: Glossary of DNA (courtesy MERIT CyberSecurity technical library)
  • Appendix-B: Landmine Nobel sweet irony
  • Appendix-C: CRISPER pioneers
  • Recommended sources
  • 2
  • History of bio-hackers, psychological profiling, and fingerprinting of the bio-hacker
  • The chemistry of DNA bio-hacking
  • Hackers wear four colorful hats
  • The emergence of DNA bio-hacking
  • Hall of fame of DNA bio-hackers
  • Advanced DNA bio-hacking technologies
  • The cloud of malware of DNA bio-hacking
  • Eysenck's theory
  • Profiling, Dr. Edward Jones, our actor
  • Our hypothetical DNA lab
  • A change of belief
  • Dr. Edward's DNA-hacking rationale
  • Data guardian turned into hacker
  • The ``toxic stress'' syndrome
  • DNA-hacker fingerprinting
  • The crime databases
  • The combined DNA index system (CODIS)
  • The national crime information center DB (NCIC)
  • How does ransomware work?
  • The story of the recent North Korean WannaCry ransomware attack
  • What's the next step for Dr. Edward?
  • Appendices.
  • Appendix-A Glossary: Courtesy of The National Academies of Sciences, Engineering, and Medicine
  • Notes: Hans Eysenck
  • Recommended sources
  • 3
  • The E. coli story as the carrier of DNA malware code
  • What is Escherichia coli (E. coli)?
  • Defense by offense
  • The CRISPR-Cas immunity projects
  • CODIS data bank structures
  • The malicious code injection method
  • Dr. Edward's bio-attack plan
  • Strategic attack timeline
  • Anatomy of spyware
  • Spyware's spying process
  • Digital malware data destruction process
  • DNA sequence malware setup
  • DNA fingerprinting
  • Design of the DNA sequence malware
  • The drone flight for malware delivery
  • DNA genome browser
  • Genome browser users
  • Appendices
  • Appendix-A SQL storage on DNA
  • Appendix-B SQL command converted to DNA code
  • Appendix-C DNA profiling (fingerprinting) technology
  • Appendix-D how to convert gene sequence into protein
  • Appendix-E the BLAST browser
  • Appendix-F glossary of genome technology extracted from MERIT cybersecurity library
  • Recommended sources
  • 4
  • CRISPR the magical knife, the good, the bad, and the ugly
  • A warmup thought
  • Crystal balling the future with blurry vision
  • Game-changing discovery, an eureka moment
  • Doudna and Charpentier get nobel
  • Historical CRISPR ovation
  • CRISPR the new sunrise of gene editing
  • The grim side of CRISPR
  • The partners who are racing for bio-genetics fame
  • Jennifer A. Doudna
  • Emmanuelle Charpentier
  • Feng Zhang
  • Embryo concerns
  • A crack in the creation
  • Doudna meets Charpentier
  • Nobel 2020 winners in chemistry
  • CRISPR timeline
  • The impossible became possible
  • The Frankenstein unfortunate legacy
  • Genetic manipulation gone awry
  • He Jiankui, China's Dr. Frankenstein
  • Who is He Jiankui?
  • Lulu and Nana
  • Appendices
  • Appendix-A: the human genome
  • The Human Genome Project (HGP).
  • Appendix-B: CRISPR glossary from MERIT cybersecurity archive library
  • Recommended sources
  • 5
  • The genome vandalism. ``When ISIS meets CRISPR''
  • A precious thought
  • The next generation of bio-hacking
  • ISIS, the army from hell
  • ISIS was born
  • The bitcoin story
  • Bio-hacking is a money-making service
  • ISIS meets CRISPR
  • CRISPR 101
  • DNA 101
  • DNA physical and sequence data banking
  • DNA ecosystem
  • Anatomy of DNA synthesizers
  • Anatomy of DNA sequencers
  • Anatomy of CRISPR
  • Miraculous power of CRISPR
  • Autonomy of the human genome (NHG)
  • Mapping of the genome
  • Hard copy of the genome
  • Bio vandalism and genetically engineered bioweaponry-the new paradigm shift
  • Bio-hacking strategies and tools
  • Hacking the prison computer systems, it really happened
  • CRISPR the unethical sawing machine, gene-editing babies
  • SARS-CoV-2 omicron variant
  • The virus started in Wuhan, China
  • Generating malicious DNA sequence
  • DNA forensics, going back in time with reverse bio-hacking
  • Genome vandalism
  • Hacking the human genome databases
  • What are the databases
  • Bio-hacking DNA ecosystem
  • Bio-hacking DNA data storage
  • The Trojan horse saga
  • The Trojan horse malware
  • The ransom formula
  • The Dillinger ransome
  • DNA bio-hacking with website-powered ransom attack
  • DNA bio-hacking with SQL injection (SQLI) attack
  • DNA bio-hacking with microchip
  • A word on RFID
  • DNA bio-hacking with external buffer overflow payload
  • DNA bio-hacking with internal sequenced malicious binary
  • Appendices
  • Appendix-A: Strategic terms used in DNA cyber hacking
  • Appendix-B: The national center for biotechnology information (BCBI)
  • Appendix-C: Immune-system arms race
  • Appendix-D: DNA data format
  • Recommended sources
  • 6
  • The E. Coli plasmids and COVID-19 saga, loaded directly into DNA
  • DNA the new beast.
  • Anatomy of coronavirus
  • Bio-hacking DNA with COVID-19
  • The CORONA attack (Act-1)
  • The CORONA attack (Act-2)
  • Neuro-invasion of COVID-19 in the human brain
  • E. Coli physical transport (spyware delivery)
  • Pathogens transported into DNA lab
  • Lab definitions
  • DNA bio-hacking with FASTQ method
  • Appendices
  • Glossary of COVID-19-from MERIT CyberSecurity consulting
  • References
  • 7
  • DNA fingerprinting, biohacking-as-a service to alter criminal records from DNA national Banks
  • God created the fingers, we created the DNA fingerprinting
  • DNA is the Holy Grail
  • DNA profiling is the enemy of privacy
  • Bio-medical engineering and bio-informatics
  • Definition of forensic science
  • In the beginning we had fingerprints
  • Definition of human fingerprinting
  • IAFIS-the integrated automated fingerprint identification system
  • AFIS (automated fingerprint identification system) record layout
  • hacking IAFIS system
  • The million stolen fingerprints
  • DNA profiling
  • Mitochondrial DNA
  • The two bio-hacking scenarios
  • Scenario-1: hacking the combined DNA index system (CODIS)
  • Introduction
  • Architecture of the almighty CODIS
  • NDIS the smart DNA indexing engine of CODIS
  • CODIS technology and DNA analysis
  • Biohacking-as-a-service (BhaaS) organizations
  • The strategy of attack on CODIS
  • CODIS vulnerabilities
  • REDIS: remote dictionary server (Redis)
  • CODIS management
  • CODIS storage stats
  • Hacking CODIS execution
  • Hacking the combined DNA index system (CODIS)
  • Scenario-1 hacking CODIS DNA criminal database
  • Hacker's zero day
  • Scenario-2 hacking genome databanks
  • Goals for the human genome project (HGP)
  • Medical implications
  • The human genome data resources
  • First step in hacking HGP: knowing the CODIS system as a geneticist and system guru
  • Blast search engine
  • Important database tools.
  • The cancer moonshot project
  • Hacking prerequisites
  • Biometrics technologies
  • Group-1 biological evidence
  • Group-2 biometric evidence
  • Group-3 external evidence
  • Hacking biometrics technologies
  • A snapshot of history
  • The medical examiner system
  • CODIS
  • The onion router (TOR) and the dark web
  • The onion router
  • The dark web
  • Appendix
  • Appendix-A REDIS technology
  • Appendix-B Glossary of CODIS
  • ASCII
  • Accredited laboratory
  • Administrative removal
  • Allele
  • Arrestee
  • Arrestee hit
  • Arrestee index
  • Assessment
  • Auto searcher
  • Base pair distance
  • Benchwork match
  • Biological child
  • Biological father/mother
  • Biological sibling
  • Cambridge reference
  • Candidate match
  • Candidate profile
  • Case disposition
  • Case report
  • Casework laboratory
  • CJIS-WAN
  • CMF
  • CODIS
  • CODIS administrator
  • CODIS core loci
  • CODIS information technology (IT) user
  • CODIS custodian/supervisor
  • CODIS user
  • CODIS user role (in the CODIS software)
  • Contract laboratory
  • Control certification form
  • Cold hit
  • Composite DNA profile
  • Convicted offender
  • Convicted offender index
  • Convicted offender lab
  • Convicted offender sample
  • Convicted offender profile
  • Conviction match
  • Criminal justice agency
  • Criminal history record
  • DAO
  • Databank coordinator
  • DCJS
  • DCJS match letter
  • Deduced missing person
  • Detainee
  • Detainee index
  • DNA analysis backlog elimination act
  • DNA analyst
  • DNA databank
  • DNA hits
  • DNA identification act
  • DNA profile
  • DNA record
  • Elimination sample
  • Employee
  • Exact match
  • Executive law article 49-B section 995
  • Expert system
  • Expungement
  • Familial search
  • FBI
  • Forensic DNA laboratory
  • Forensic DNA profile
  • Forensic DNA testing
  • Forensic hit (FH)
  • Forensic index
  • Forensic mixture category
  • Forensic mixture index.