Perinatal and developmental epigenetics /
Perinatal and Developmental Epigenetics, Volume 32, a new volume in the Translational Epigenetics series, provides a thorough overview of epigenetics in the early developmental and perinatal stages, illuminating pathways for drug discovery and clinical advances.
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| Format: | eBook |
| Language: | English |
| Published: |
London ; San Diego, CA :
Academic Press, an imprint of Elsevier,
[2023]
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| Series: | Translational epigenetics series ;
v. 35. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Front Cover
- Perinatal and Developmental Epigenetics
- Translational Epigenetics Series
- Translational Epigenetics Perinatal and Developmental Epigenetics
- Copyright
- Contents
- Contributors
- 1
- The ever-growingcomplexity ofepigenetic regulationof gene expression
- 1
- Epigenetic regulation of gene expression: an overview of classical and recently discovered novel players
- Introduction
- DNA methylation
- DNMTs and DNA-binding proteins
- Importance of epigenetic reprogramming during development
- Role of DNA methylation in embryonic stem cells
- Pathological impact of altered DNA methylation
- Genomic imprinting
- Epigenetic mechanisms of gene regulation for imprinted genes
- Establishing epigenetic marks on imprinted genes
- Role of genomic imprinting in development
- Role of genomic imprinting in fetoplacental development
- Genomic imprinting and X-chromosome inactivation
- Histone modifications
- Types of histone modifications
- Regulation of gene expression by histone modifications during embryonic and perinatal development
- Nucleosome remodeling
- Chromatin structure of embryonic stem cells
- Ontogeny of chromatin remodeling
- Higher-order chromatin organization (topologically associating domains)
- Pathological impact of deregulation in histone modifications
- Noncoding RNAs
- Regulation of gene expression by noncoding RNAs during embryonic and perinatal development
- Small noncoding RNAs (miRNAs and siRNAs)
- Piwi-interacting RNAs
- Long noncoding RNAs
- Interaction of lncRNAs with chromatin-modifying complexes
- Pathological impact of deregulation in lncRNAs
- Effect of different conditions on Epigenetic mechanisms and programming of human health and disease risk
- Impact of prenatal stress on epigenetic modifications
- Long-term impacts of epigenetic deregulation during childhood.
- Effect of acute intrapartum events on epigenetic mechanisms
- References
- 2
- Histone modifications in germline development and maintenance
- Dynamic reorganization of histone PTMs supports germ cell development, identity, and functions in mammals
- Description of histone PTMs and their dynamics
- From PGC specification to birth
- During gametogenesis
- Histone PTMs cooperate to regulate germline functions and shape the epigenetic landscape
- Histone PTMs in meiotic recombination
- Histone PTMs and meiotic sex chromosome inactivation
- Histone PTMs and transcriptional control during gametogenesis
- Histone PTMs distribution and function in Caenorhabditis elegans hermaphrodite germ cells
- Distribution of histone PTMs in the Caenorhabditis elegans germline
- Repressive chromatin structure in the P blastomeres and PGC
- Chromatin landscape in the adult hermaphrodite germline
- Role of histone PTMs in transcriptional regulation in the Caenorhabditis elegans germline
- X chromosome silencing
- Histone PTMs and transcriptional memory
- Histone PTMs and maintenance of germline identity
- Histone PTMs and transgenerational epigenetic inheritance of environmental conditions
- H3K9 methylation and genome stability
- Concluding remarks
- References
- 3
- Epigenetic regulation of cis-regulatory elements and transcription factors during development
- Epigenetic mechanisms govern developmental processes via Genome regulation
- cis-regulatory elements and trans-acting factors orchestrate Cell type-specific gene transcription
- Trans-acting factors
- Transcription factors
- Noncoding RNAs
- Making the connections: readers and writers program the epigenome during early development
- Three-dimensional genome organization
- Identification and characterization of cis-regulatory elements and trans-acting factors.
- Conserved sequences and chromatin features aid in the identification of regulatory elements
- Sequence conservation and characteristic motifs
- Chromatin features
- Emergent approaches for the identification of regulatory elements
- Computational methods for harnessing epigenomic data sets to predict regulatory elements
- Epigenetic programming in perinatal and early development
- Switching chromatin states-dynamic epigenomic landscape at developmental cis-regulatory elements
- Trans-regulatory networks govern stem cell pluripotency and differentiation
- Regulatory elements in early development inform adult health and disease states
- Conclusion
- References
- 4
- Genomic imprinting and developmental physiology: intrauterine growth and postnatal period
- Genomic imprinting: discovery and early work
- Imprinted gene functions converge on neuronal and metabolic processes that govern early development: The cost of altered im ...
- Genomic imprinting-mediated control of fetal growth and placental resources
- Genomic imprinting and human imprinting disorders
- Imprinted genes regulate multiple maternal-fetal interactions and are essential for early survival
- Postnatal control of growth and development is mediated by imprinted genes via key metabolic systems and is crucial for pre ...
- Final comments
- References
- 5
- Role of RNA epigenetics in development
- Introduction
- RNA modifications
- RNA N6-methyladenosine modification (m6A)
- RNA 5-methylcytosine (m5C) modification
- RNA A-to-I editing
- Role of RNA modifications in development
- Conclusion and future perspective
- References
- 2
- Epigenetic programming of placenta regulatesshort-term and long-term health outcomes
- 6
- Epigenetic regulation of placental function
- Introduction
- Epigenetic regulation during placentation.
- Epigenetics and human placenta development
- Epigenetics and mouse placental development
- Transcriptional factors and trophoblast lineage differentiation
- Epigenetics and regulation of trophoblast functions
- Epigenetic mechanisms regulating placental development and function
- DNA methylation
- DNA methylation in trophoblast
- DNA methylation and regulation of placental nutrient transfer
- Genomic imprinting
- Genomic imprinting and regulation of placental endocrine function
- Histone modifications and placental functions
- Noncoding RNA
- miRs
- C19MC in placental functions
- C14MC in placental function
- C2MC in placental functions
- Long noncoding RNAs
- Epigenetics and placenta-related pathologies
- Epigenetics and preeclampsia
- Epigenetics and gestational diabetes
- Epigenetics and intrauterine growth restriction
- Conclusion
- References
- 7
- Role of placenta in developmental programming of sex-specific adult outcomes
- Mechanisms of developmental programming
- Sex-specific effects and disease programming in utero
- References
- Further reading
- 3
- Epigenetics,hormones, sex,and developmental programming
- 8
- Role of epigenetics in shaping sex differences in brain development and behavior
- Introduction
- Introduction to epigenetics
- Gonadal steroid hormones drive sexual differentiation and are epigenetic modifiers
- An extreme sex difference in epigenetic regulation: X chromosome inactivation
- Sex differences in the human epigenome: normal development
- DNA methylation
- Histones and microRNAs
- Genomic imprinting
- Implications for neurological disorders and diseases
- Sex differences in the brain epigenome: rodent studies
- DNA methylation
- Histone modifications
- Sex differences in the epigenetic writers, erasers, and readers
- DNA methylation
- Histone modifications
- MicroRNAs.
- Manipulating epigenetic marks during development: effects on sexual differentiation of neural morphology and behavior
- Manipulating epigenetic marks during development: sexual differentiation of neurochemistry
- Future directions
- References
- 4
- Epigenetic programming by adverse perinatal influences
- 9
- Early-life stress exposure and epigenetic programming
- Introduction to epigenetics
- History of epigenetics
- Epigenetic mechanisms
- DNA methylation
- Histone modifications
- Nucleosome positioning
- Small noncoding RNAs
- Mechanisms of stress
- Stress and early-life stress
- The hypothalamic-pituitary-adrenal and sympathetic-adrenal-medullary axes
- Developmental and physiological overview
- Stress and oxytocin
- Stress and the serotonergic system
- Stress and brain-derived neurotrophic factor
- Candidate early-life stress-mediated epigenetic markers
- The glucocorticoid receptor (NR3C1)
- FK506-binding protein
- The mineralocorticoid receptor (NR3C2)
- The oxytocin receptor
- Solute carrier family 6 member 4 and monoamine oxidase-A
- Brain-derived neurotrophic factor
- Conclusion
- References
- 10
- Early life substance abuse and epigenetic programming
- Substance abuse and substance use disorders
- Epigenetics and gene expression regulation
- Histone modification
- DNA methylation
- RNA-associated modifications
- Inherited predispositions (i.e., susceptibility of future generations)
- Early drug use and epigenetic modifications
- Nicotine
- Alcohol
- Cocaine
- Marijuana/THC
- Opioids
- Molecular strategies targeting epigenetic modifications as novel therapeutics for treatment
- Conclusions
- References
- 11
- Paternal and maternal environmental influences on offspring health: inter- and transgenerational epigenetic in ...
- Introduction
- Germline epigenome and reprogramming
- DNA methylation.