Stem cell therapy : practical considerations /
| Main Authors: | , |
|---|---|
| Corporate Author: | |
| Format: | eBook |
| Language: | English |
| Published: |
London ; San Diego, CA :
Academic Press,
[2023]
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| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Front Cover
- Stem Cell Therapy
- Copyright Page
- Dedication
- Contents
- I. Stem cells: basic biology
- 1 Introduction
- 1.1 Establishing the concept of stem cells
- Further reading
- 2 Anatomy and Histology
- 2.1 Blood supply
- 2.2 Niche
- 2.3 Hemopoietic stem cell niches
- 2.4 Differences between osteoblastic and vascular niches
- 2.5 Components of the hemopoietic stem cell niche
- 2.6 Mesenchymal stem cell niche
- 2.6.1 Bone marrow mesenchymal stem cell niche
- 2.7 Mesenchymal stem niche in adipose tissue
- 2.7.1 Epidermal stem cell niche
- 2.7.2 Intestinal epithelial niche
- 2.8 Niche functions
- 2.9 Regulation of niche function
- Further reading
- 3 Stem cells: definition, biological types, classifications, and properties
- 3.1 Definition
- 3.2 Classification
- 3.3 Properties
- 3.3.1 Potency
- 3.3.1.1 Totipotent stem cells
- 3.3.1.2 Pluripotent stem cells
- 3.3.1.3 Molecular determinants of pluripotency
- 3.3.1.4 Cell cycle profile of pluripotency
- 3.3.1.5 Multipotent stem cells
- 3.3.1.6 Oligopotent stem cells
- 3.3.1.7 Bipotent stem cells
- 3.3.1.8 Unipotent stem cells
- 3.3.2 Self-renewal
- 3.3.2.1 Regulation of self-renewal
- 3.3.3 Stem cell plasticity
- 3.3.4 Evidence of stem cell transdifferentiation
- 3.3.5 Theories of transdifferentiation
- 3.3.5.1 Requirements for proof of transdifferentiation
- 3.3.5.2 Factors affecting frequency of transdifferentiation
- 3.3.5.3 Induction of transdifferentiation
- 3.3.5.4 Evaluation of transdifferentiation
- 3.4 Differentiation
- 3.5 Homing and engraftment
- 3.5.1 Definition
- 3.5.2 Mechanism of homing
- 3.5.3 Enhanced and directed homing
- 3.5.4 Stem cell trafficking
- 3.5.5 Mechanism of stem cell trafficking
- 3.5.6 Role of stem cell trafficking in regeneration
- Further reading
- II. Stem cell induced regeneration: principles and applications
- 4 Mechanisms of stem cell-related regeneration
- 4.1 Regulation of tissue regeneration
- 4.2 Overview of the mechanism of regeneration
- 4.2.1 Transdifferentiation
- 4.2.2 Contribution to tissue regeneration
- 4.2.3 Variation in transdifferentiation potential
- 4.2.4 Molecular mechanisms of transdifferentiation
- 4.3 Signaling pathways involved in stem cell transdifferentiation
- Mogrify algorithm
- 4.4 Activation of endogenous repair system
- 4.5 Induction of angiogenesis
- 4.5.1 Variability in angiogenic potential of mesenchymal stem cells
- 4.6 Secretory function
- 4.6.1 Microvesicles and exosomes
- 4.6.2 Paracrine action
- 4.7 Mitochondrial transfer
- 4.7.1 Inducers of transfer
- 4.7.2 Mechanisms
- 4.7.3 Effects
- 4.7.4 Variability in mitochondrial transfer according to mesenchymal stem cell source
- 4.8 Microenvironment modulation
- 4.9 Conclusion
- Further reading
- 5 Sources of stem cells for regenerative purposes
- 5.1 Characteristics of the ideal source of stem cells
- 5.2 Sources of mesenchymal stem cells