Smart nanomaterials for bioencapsulation /

Smart Nanomaterials for Bioencapsulation focuses on the fundamentals, synthesis methods and matrix design for the encapsulation of drugs, drug release, food and nutraceuticals, mechanisms of nano- encapsulated drugs on liposomes, micelles, silica composites, carbon nanotubes, dendrimers, and protein...

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Bibliographic Details
Corporate Author:	ScienceDirect (Online service)
Other Authors:	Castro, Guillermo R. (Editor), Nadda, Ashok Kumar (Editor), Nguyen, Tuan Anh (Editor), Sharma, Swati (Editor), Gupta, Ram K. (Editor)
Format:	eBook
Language:	English
Published:	Amsterdam, Netherlands : Elsevier, [2023]
Series:	Micro & nano technologies.
Subjects:	Drugs > Coatings. Nanostructured materials > Therapeutic use. Capsules (Pharmacy) Drug carriers (Pharmacy) Capsules Nanoparticle Drug Delivery System Drug Carriers Nanostructures Médicaments > Enrobages. Nanomatériaux > Emploi en thérapeutique. Capsules (Pharmacie) Vecteurs de médicaments. Drugs > Coatings Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Front cover
Half title
Title
Copyright
Contents
Contributors
Chapter 1 Hybrid systems in bio-encapsulation
1.1 Introduction
1.2 Crystalline calcium carbonate
1.3 Synthesis of CaCO3 particles
1.3.1 Solution route
1.3.2 Evaporation-diffusion route
1.3.3 Carbonation route
1.4 Characterization of crystalline calcium carbonate
1.4.1 Microscopic analysis
1.4.2 Spectroscopic analysis
1.4.3 Scattering analysis
1.4.4 Thermal analysis
1.4.5 Porosity and surface area analysis
1.4.6 Drug loading and drug release studies
1.5 Cytocompatibility of CaCO3 particles
1.6 CaCO3 particles as drug carriers
1.6.1 Drug delivery
1.6.2 Anticancer drug delivery
1.6.3 Protein delivery
1.6.4 Gene delivery
1.6.5 CaCO3 as carriers for biosensing and bioimaging
1.6.6 CaCO3 as carriers for radiotherapy
1.7 Conclusion
Declaration of competing interest
Acknowledgements
References
Chapter 2 Polysaccharides as natural nanoencapsulants for controlled release of compounds
2.1 Introduction
2.2 Structure, properties, and health benefits of natural polysaccharide
2.3 Development of smart polysaccharide-based delivery systems of bioactive compounds
2.3.1 The natural polysaccharides to be used in delivery systems
2.4 Interactions between biopolymers for nanoencapsulation
2.5 Polysaccharide-based nanocompounds as potential delivery systems for bioactive compounds: applications and future perspectives
2.6 Conclusion and further remarks
References
Chapter 3 Application in gene therapy and DNA/RNA vaccines
3.1 Introduction
3.2 Gene therapy: principles and strategies for DNA/RNA editing approaches
3.2.1 RNA editing approaches
3.2.2 DNA editing approaches
3.3 DNA and RNA vaccines: general concepts, mechanisms of action and their advantages and limitations.
3.3.1 Mechanism of action
3.3.2 Advantages and limitations
3.3.3 RNA-based vaccines
3.4 DNA/RNA delivery methods: viral versus nonviral vectors
3.4.1 Viral vectors
3.4.2 Nonviral methods
3.5 Nanomedicines as vaccine adjuvants
3.6 Current status of nanomedicines for gene therapy and DNA/RNA vaccines: preclinical and clinical studies
3.7 Conclusions
References
Chapter 4 Delivery of bioencapsulated proteins
4.1 Introduction
4.2 Protein bioencapsulation development
4.3 Challenges in protein and peptides bioencapsulation
4.4 Nanomaterials and strategies for protein nanoencapsulation
4.4.1 Organic nanomaterials
4.4.2 Protein nanomaterials
4.4.3 Inorganic nanomaterials
4.4.4 Hybrid nanosystems
4.5 Conclusion
Acknowledgment
References
Chapter 5 Smart bio-encapsulation for immunotherapy
5.1 Introduction (Immunotherapy)
5.2 Immunotherapy strategies
5.3 Checkpoint inhibitors
5.3.1 Cell surface checkpoint inhibitors
5.3.2 Intracellular checkpoint inhibitors
5.4 Cytokine
5.5 Vaccines
5.6 Immune cell therapy
5.7 Smart nanocarriers for immunotherapy
5.7.1 Polymeric nanoparticles
5.7.2 Membrane-camouflaged nanoparticles
5.7.3 Lipid-based nanoparticles
5.7.4 Inorganic nanoparticles
5.7.5 DNA origami
5.7.6 Exosome
5.7.7 Virus-like particles
5.8 Conclusion
References
Chapter 6 Bioencapsulation for protein delivery
6.1 Introduction
6.2 The characteristics of proteins for bioencapsulation
6.3 Coating components in bioencapsulation
6.3.1 Solvent
6.3.2 Polymers in bioencapsulation
6.3.3 Plasticizers
6.4 Methods of bioencapsulation
6.4.1 Spray drying
6.4.2 Spray chilling
6.4.3 Fluidized bed coating
6.4.4 Freeze-drying
6.4.5 Emulsification
6.4.6 Extrusion
6.4.7 Complex coacervation
6.4.8 Compression coating.
6.5 Bioencapsulation using smart polymers
6.5.1 Polymeric nanoreservoirs
6.5.2 Polymeric microcapsules
6.5.3 Polymeric micelles
6.5.4 Hydrogels
6.6 Bioencapsulation by nanoparticle and microparticle system for protein delivery
6.6.1 Inorganic carriers
6.6.2 Dendrimer based protein delivery
6.6.3 Liposome based protein delivery
6.6.4 Plant cell based protein delivery
6.6.5 Bacteria mediated protein delivery
6.6.6 Yeast mediated protein delivery
6.7 Advantages of bioencapsulating proteins
6.8 Challenges in bioencapsulation of proteins
6.9 Future prospects and conclusion
Acknowledgment
References
Chapter 7 Bioencapsulation for probiotics
7.1 Introduction to probiotics
7.1.1 Types of probiotics
7.1.2 Health benefits
7.1.3 Properties of probiotics
7.2 Bioencapsulation of probiotics
7.2.1 Introduction to bioencapsulation
7.2.2 Types of wall material used in bioencapsulation
7.2.3 Techniques of bioencapsulation for probiotics
7.2.4 Mechanism of bioencapsulation for probiotics
7.3 Characterization and properties of encapsulated probiotics
7.3.1 Physical properties of encapsulated probiotics
7.3.2 Stability and shelf life of encapsulated probiotics
7.3.3 Bioavailability and release properties of encapsulated probiotics
7.4 Issues and challenges in the bioencapsulation for probiotics
7.4.1 Technical challenges and shortcomings
7.4.2 Scaling up and commercialization
7.4.3 Roads to alternative lines of product
7.5 Future of the bioencapsulation for probiotics
References
Chapter 8 Bioencapsulation for the functional foods and nutraceuticals
8.1 Food additives
8.2 Bioencapsulation for food additives
8.2.1 Introduction to bioencapsulation
8.2.2 Types of wall material used in bioencapsulation.
8.2.3 Techniques of bioencapsulation for food additives
8.2.4 Mechanism of bioencapsulation for food additives
8.3 Characterization and properties of encapsulated food additive
8.3.1 Physical properties and stability of encapsulated food additive
8.3.2 Bioavailability and release properties of encapsulated food additive
8.4 Issues in the bioencapsulation for food additive
8.5 Future and challenges of the bioencapsulation for food additives
References
Chapter 9 Bioencapsulation of proteins in therapeutics
9.1 Introduction
9.2 Characteristics of therapeutic proteins
9.3 Therapeutic proteins of biotechnological origin
9.4 Strategies for modeling the pharmacokinetic and pharmacodynamic characteristics of therapeutic proteins
9.5 Methods and materials for encapsulation of therapeutic proteins
9.5.1 Physical encapsulation
9.5.2 Covalent bond encapsulation
9.5.3 Microparticles and nanoparticles
9.5.4 Conjugation of proteins with polyethylene glycol (PEGylation)
9.5.5 Hyperglycosylation of proteins
9.6 Conclusions and future prospects
References
Chapter 10 Bioencapsulation for food additives
10.1 Introduction
10.2 Encapsulation processes
10.2.1 Spray drying
10.2.2 Freeze drying
10.2.3 Air-suspension coating
10.2.4 Centrifugal suspension-separation
10.2.5 Centrifugal extrusion
10.2.6 Cocrystallization
10.2.7 Coacervation
10.2.8 Molecular inclusion in cyclodextrins
10.2.9 Liposomes
10.2.10 Extrusion
10.2.11 Emulsions
10.2.12 Microemulsions and nanoemulsions
10.3 Coating materials
10.4 Characterization of encapsulated materials
10.5 Encapsulation applications in food industry
10.6 Encapsulation of lactic acid bacteria and probiotics
10.7 The use of encapsulation technology for inhibition of pathogens.
10.8 The use of encapsulat^^c4^^b1on technology for the prevention of fish oil oxidation
10.9 The use of encapsulation technology to improve the quality of meat products
10.10 Results and future suggestions
References
Chapter 11 Theragnostic applications
11.1 Introduction
11.2 Evolution of theragnosis
11.3 In vivo imaging modalities
11.4 Treatment strategies
11.4.1 Photodynamic therapy (PDT)
11.4.2 Photothermal therapy (PTT)
11.4.3 Fluorophores
11.4.4 Electric and magnetic field activation
11.5 Nanotheragnostics
11.6 Nanomaterials with theragnostic applications
11.7 Radionuclides associated with nanocarriers
11.8 Metallic nanoparticles
11.8.1 Gold (Au)
11.8.2 Gadolinium (Gd)
11.8.3 Iron (Fe)
11.8.4 Quantum dots (QD)
11.8.5 Carbon-based nanostructures
11.9 Future of clinical studies
References
Chapter 12 Nanotechnology in agriculture and bioencapsulation of probiotics/food additives
12.1 Introduction
12.2 Application of nanotechnology in agriculture
12.2.1 Crop improvement
12.2.2 Nonofertilizers
12.2.3 Remediation of toxic pollutants
12.2.4 Crop protection
12.3 Bioencapsulation for probiotics and food additives
12.3.1 Bioencapsulation for probiotics
12.3.2 Bioencapsulation for food additives
12.4 Conclusion
Acknowledgement
References
Chapter 13 Smart systems in bio-encapsulation for cancer therapy
13.1 Introduction
13.2 Smart nanocarrier-based delivery systems
13.3 The tumor microenvironment as the target site for smart systems
13.3.1 Stimuli-response mechanisms and drug release
13.4 Conclusion and perspectives
References
Chapter 14 Nanoencapsulation for production of fermented foods and pigments
14.1 Introduction
14.2 Nanoencapsulation methods
14.3 Strategies for the production of nanoparticles.