rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: How synthetic drugs work
    sub title: insights into molecular pharmacology of classic and new pharmaceuticals
  name:
    name part: Kazmi, Imran.
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: Electronic books.
  origin info:
    place:
      place term: xx
    place:
      place term: S.l.]
    publisher: Academic Press
    date issued: 2022
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource
  abstract: "How Synthetic Drugs Work: Insights into Molecular Pharmacology of Classic and New Pharmaceuticals provides comprehensive, structured access to robust information on molecular pharmacology for clinicians, research scientists and advanced health care students. The book covers the foundations of molecular pharmacology and the main drug classes, including detailed information on their mechanisms of action and the application of molecular pharmacology in drug development."--
  table of contents: Front Cover -- How Synthetic Drugs Work -- Copyright Page -- Contents -- List of contributors -- 1 Introduction to molecular pharmacology: basic concepts -- Pharmacology -- Drugs -- Brief history of pharmacology -- Routes of drug administration -- Enteral routes -- Parenteral routes of drug administration -- Local routes of drug administration -- Pharmacokinetics -- Passive diffusion -- Filtration -- Specialized transport -- Carrier transport -- Active transport -- Facilitated diffusion -- Pinocytosis -- Absorption -- Factors affecting absorption of drugs -- Physical factors -- Blood perfusion to the site of administration -- Surface area available for absorption -- Retention time at the surface area -- Drug distribution -- Volume of distribution -- Water compartments in the body -- Plasma compartment -- Extracellular fluid -- Total body water -- Other sites -- Apparent volume of distribution -- Plasma protein binding of the drugs -- Drug metabolism -- Kinetics of metabolism -- Phase I reactions -- Phase II reactions -- Drug excretion -- Pharmacodynamics: drug receptor interactions or mechanism of drug effects -- Principles of drug action -- Stimulation -- Depression -- Irritation -- Replacement -- Cytotoxic action -- Mechanism of drug actions -- Physical action -- Chemical action -- Through enzymes -- Through receptors -- Some important definitions -- Agonists -- Inverse agonist -- Antagonist -- Partial agonist -- Ligand -- Nature of receptors -- Transducer mechanisms -- G protein-coupled receptors -- Receptors with intrinsic ion channels -- Rho/Rho kinase -- The mitogen activated protein kinases -- Enzymatic receptors -- Rat Sarcoma (RAS)/Rapidly Accelerated Fibrosarcoma (RAF) pathway -- Janus kinases (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway -- Nuclear receptors -- Reference.
  table of contents: Bromocriptine -- Na+-Glucose transporter-2 inhibitors -- GLP-1 agonist -- Exenatide -- Liraglutide -- Albiglutide -- Other glucose-lowering agents -- Pramlintide: amylin analog -- References -- 6 Molecular mechanism of action of estrogens, progestins, and androgens -- Introduction -- Synthesis of endogenous estrogens, progesterone, and androgens -- Mechanism of action of endogenous steroid sex hormones (estrogens, progesterone, and androgens) -- Role of estrogen, progesterone, and androgen in diseases -- Hormonal imbalance in females -- Polycystic ovary syndrome -- Hormonal imbalance in males -- Cancer -- Synthetic estrogens, progestins, and androgens for treatment of hormone-related diseases -- Hormonal therapy -- Mechanism of action of synthetic estrogens -- Mechanism of action of progestins -- Mechanism of action of synthetic Androgens -- References -- 7 Mechanism of action of sedatives, hypnotics, and antianxiety drugs -- Introduction -- Generalized mode of action of anxiolytics, sedatives/hypnotics -- Anxiety and antianxiety medications -- Novel molecules with diverse pharmacological targets -- Systems containing monoamines -- Vilazodone -- AVN-101 -- Brexpiprazole -- Cyclobenzaprine VLD (TNX-102) -- Glutamate system -- Ketamine -- Xenon gas (NBTX-001) -- Endocannabinoid system -- Inhibitors of fatty acid amide hydrolase -- Additional targets for the eCB system -- GABA system -- Sedatives and hypnotics -- Benzodiazepines -- Additional agents -- Hypnotics are used to induce and maintain anesthesia -- Selection of a hypnotic agent -- Sedatives/anesthetics administered intravenously -- Closing remarks -- References -- 8 Mechanism of action of antiepileptic drugs -- Introduction -- Pathophysiology and pathogenesis of epilepsy -- Role of GABA -- Role of glutamate -- General treatment -- Phenobarbital mechanism of action.
  table of contents: Bromide (potassium bromide/sodium bromide) -- Phenytoin mechanism of action -- Benzodiazepines mechanism of action -- Carbamazepine mechanism of action -- Ethosuximide mechanism of action -- Valproic acid mechanism of action -- Gabapentin mechanism of action -- Newer antiepileptic drugs -- Mechanism of action of eslicarbazepine acetate -- Levetiracetam -- Brivaracetam -- Lacosamide -- Perampanel -- Cannabidiol -- Stiripentol -- Conclusion -- References -- 9 Mechanism of action of anti-Parkinson's drugs -- Introduction to Parkinson's disease -- Parkinson's disease symptoms, and its subtypes -- Epidemiology and risk factors for Parkinson's disease -- Substantia nigra and its association with neuronal components -- Pathophysiology and pathoanatomy of Parkinson's disease -- Anti-Parkinson's disease drugs -- Levo-DOPA -- Dopamine agonists -- Catechol-o-methyltransferase -- Catechol-O-methyltransferase inhibitors and Parkinson's disease -- Monoamine oxidase -- Monoamine oxidase-A and monoamine oxidase-B -- Inhibitors of monoamine oxidase-A and monoamine oxidase-B -- Monoamine oxidase-B inhibitor selegiline and Parkinson's disease -- Monoamine oxidase-B inhibitor lazabemide in Parkinson's disease -- Summary -- References -- 10 Mechanism of action of antipsychotics and antimanics -- Introduction -- Psychological disorders at a glance -- Behaviors represented by a psychological disorder -- Definition of physiological disorders -- Common symptoms of psychological disorders -- Physical symptoms of psychological disorders -- Some serious symptoms that might indicate a life-threatening condition -- Causes psychological disorders -- Risk factors for psychological disorders -- Treatment of psychological disorders -- Common treatments for psychological disorders -- Ways to improve your psychological disorders -- Potential complications of psychological disorders.
  note: edited by Imran Kazmi, Sanmoy Karmakar, Md Adil Shaharyar, Muhammad Afzal, Fahad A. Al-Abbasi.
  subject:
    topic: Synthetic drugs
    topic: Physiological effect
  subject:
    topic: Molecular pharmacology
  subject:
    topic: Synthetic Drugs
    topic: pharmacology
  subject:
    topic: Synthetic Drugs
    topic: pharmacokinetics
  subject:
    topic: Molecular Mechanisms of Pharmacological Action
  subject:
    topic: Médicaments de synthèse
    topic: Effets physiologiques
  subject:
    topic: Pharmacologie moléculaire
  subject:
    topic: Molecular pharmacology
  classification: RM300
  classification: 615.1
  related item:
    identifier: (OCoLC)1283820583
  related item:
    title info:
      title: How synthetic drugs work
    identifier: (OCoLC)1314333934
  identifier: 9780323913683
  identifier: 0323913687
  identifier: 9780323998550
  identifier: 0323998550
  identifier: 9780323913683 Ingram Content Group
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: YDX
    record creation date: 220910
    record change date: 20260327173325.5
    record identifier: in00005770643
    language of cataloging:
      language term: eng