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Disorders of protein synthesis /

Disorders of Protein Synthesis, Volume 132 in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.- Provides the authority and expertise of leading con...

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Bibliographic Details
Corporate Author: ScienceDirect (Online service)
Other Authors: Donev, Rossen (Editor)
Format: eBook
Language:English
Published: Cambridge, MA : Academic Press, [2022]
Series:Advances in protein chemistry and structural biology ; 132
Subjects:
Proteins > Synthesis.
Protéines > Synthèse.
Proteins > Synthesis
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Intro
  • Disorders of Protein Synthesis
  • Copyright
  • Contents
  • Contributors
  • Chapter One: Translation termination codons in protein synthesis and disease
  • 1. Ribosome fidelity and translation termination
  • 2. Nonsense mutations and the mRNA quality control
  • 3. Ribosome readthrough
  • 3.1. Mechanism, programmed readthrough and natural vs premature stop codons
  • 3.2. Readthrough-inducing compounds
  • 3.3. The determinants of readthrough
  • 3.3.1. The sequence context
  • 3.3.2. The reinserted amino acid
  • 4. Readthrough induction as a therapeutic approach for PTC suppression
  • 4.1. Cystic fibrosis
  • 4.2. Duchenne muscular dystrophy
  • 4.3. Coagulation factor deficiencies
  • 4.4. Lysosomal storage disorders
  • 5. Conclusions
  • Author contributions
  • Funding
  • Conflicts of interest
  • References
  • Chapter Two: The disturbance of protein synthesis/degradation homeostasis is a common trait of age-related neurodegenerat ...
  • 1. Introduction
  • 2. Proteostasis: The balance between synthesis, folding and degradation
  • 2.1. Protein re-folding and surveillance
  • 2.1.1. Molecular chaperones
  • 2.1.2. The unfolded protein response
  • 2.1.3. The integrated stress response
  • 2.2. Protein degradation
  • 2.2.1. The ubiquitin proteome system
  • 2.2.2. Autophagy
  • 3. The proteostasis network in the brain
  • 3.1. Evidence of aberrant proteostasis in age-related neurodegenerative diseases
  • 3.1.1. Alzheimerś disease
  • 3.1.2. Parkinsonś disease
  • 3.1.3. Amyotrophic lateral sclerosis
  • References
  • Chapter Three: Computational and structural investigation of Palmitoyl-Protein Thioesterase 1 (PPT1) protein causing Neur ...
  • 1. Introduction
  • 2. Materials and methods
  • 2.1. Sequence and mutations retrieval
  • 2.2. Deleteriousness, stability, and conservation analysis
  • 2.3. Structural effects prediction
  • 2.4. Molecular dynamics simulation (MDS) analysis
  • 3. Results
  • 3.1. Sequence and mutations retrieval
  • 3.2. Deleteriousness, stability, and conservation analysis
  • 3.3. Structural effects prediction
  • 3.4. Molecular dynamics simulations
  • 4. Discussion
  • 5. Conclusion
  • Acknowledgment
  • Role of funding source
  • Author contributions
  • Conflict of interest
  • References
  • Chapter Four: Translation initiation and its relationship with metabolic mechanisms in cancer development, progression an ...
  • 1. Introduction
  • 2. Translation initiation and its regulation
  • 2.1. The formation of the preinitiation complex (PIC)
  • 2.2. mRNA activation by assembly with eIF4F complex and binding to the 43S PIC
  • 2.2.1. Formation of mRNA structures in 5 untranslated region (5UTR)
  • 2.3. Scanning of the mRNA-bound ribosomal complex along with the 5UTR mRNA
  • 2.4. Formation of the 80S ribosome
  • 3. The impact of translation initiation in cancer