http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
1 online resource (xx, 612 pages :) illustrations.
Front Cover -- IFC -- HEMODYNAMICS AND CARDIOLOGY: Neonatology Questions and Controversies -- Series Page -- HEMODYNAMICS AND CARDIOLOGY: Neonatology Questions and Controversies -- Copyright -- Contributors -- Preface -- Series Foreword -- Contents -- A -- Developmental Cardiovascular Physiology and Pathophysiology -- 1 -- Principles of Developmental Cardiovascular Physiology and Pathophysiology -- Principles of Developmental Physiology -- Fetal Circulation -- Transitional Physiology -- Postnatal Circulation -- Pressure, Flow, and Resistance -- Organ Blood Flow Distribution -- Microcirculatory Physiology (see Chapter 19) -- Myocardial Function-Developmental Aspects -- Developmental Cardiovascular Pathophysiology: Etiology and Pathophysiology of Neonatal Shock -- Definition and Phases of Shock -- Etiology of Neonatal Shock -- Hypovolemia -- Myocardial Dysfunction (see Chapter 26) -- Vasodilation -- Adrenal Insufficiency (see Chapter 30) -- Downregulation of Adrenergic Receptors -- Summary -- REFERENCES -- 2 -- Vascular Regulation of Blood Flow to Organs in the Preterm and Term Neonate -- Regulation of Arterial Tone -- The Role of Conduit Arteries in Regulating Vascular Resistance -- Arterial Reaction to Pressure (Autoregulation) -- Interaction of Autoregulation and Hypoxic Vasodilatation -- Interaction of Autoregulation and Pco2 -- Interaction of Autoregulation and Functional Activation (Metabolic Blood Flow Control) -- Flow-Mediated Vasodilatation -- Sympathetic Nervous System -- Humoral Factors in General Circulation -- Blood Flow to the Brain -- Autoregulation of Cerebral Blood Flow in the Immature Brain -- Effect of Carbon Dioxide on Cerebral Blood Flow -- Metabolic Control of Blood Flow to the Brain -- Adrenergic Mechanisms Affecting Cerebral Blood Flow -- Effect of Medications on Cerebral Blood Flow -- Ischemic Thresholds in the Brain.
Blood Flow to Other Organs -- Kidney -- Liver -- Stomach and Intestines -- Distribution of Cardiac Output in the Healthy Human Neonate -- Blood Flow to the Upper Part of the Body -- Blood Flow to the Lower Part of the Body -- Mechanisms Governing the Redistribution of Cardiac Output in the Fetal "Diving" Reflex -- Aerobic Diving -- Reactions to Hypoxia -- Modifying Effects -- Distribution of Cardiac Output in the Shocked Newborn -- The Term Neonate With Low Cardiac Output -- The Very Preterm Neonate During Immediate Postnatal Adaptation -- Other Scenarios -- REFERENCES -- 3 -- Definition of Normal Blood Pressure Range: The Elusive Target -- Measuring Blood Pressure -- Blood Pressure Standards -- Clinical Factors Affecting Blood Pressure -- Antenatal Steroids -- Placental Transfusion -- Respiratory Support -- Blood Pressure and Short- and Long-Term Outcomes -- Bedside Clinical Assessment and Hemodynamic Monitoring -- Conclusion -- REFERENCES -- B -- Hemodynamic Principles of Postnatal Transition -- 4 -- Cardiorespiratory Effects of Delayed Cord Clamping -- The Transition to Newborn Life -- Airway Liquid Clearance -- Increase in Pulmonary Blood Flow at Birth in Response to Lung Aeration -- The Cardiovascular Transition at Birth: Effect of Umbilical Cord Clamping -- Neonatal Cardiovascular Responses to Umbilical Cord Clamping -- Neonatal Cardiovascular Consequences of Umbilical Cord Milking -- Placental Transfusion During Delayed Umbilical Cord Clamping -- Potential Mechanisms for Placental Blood Transfusion -- Gravity and Uterine Contraction -- Increase in Pulmonary Blood Flow at Birth -- Vaginal Birth -- Clinical Effects of Delayed/Deferred Umbilical Cord Clamping -- Potential Mechanisms of Benefit: Transfusion Versus Timing -- Determinants of the Placental Transfusion -- Time -- Position/Gravity -- Contractions/Oxytocics -- Mode of Delivery.
Umbilical Blood Vessel Patency -- Breathing/Crying -- Prevention of Hypotension/Low Systemic Blood Flow -- Less Intervention at Birth: Resuscitation Versus Transitioning -- Physiologically Based Cord Clamping -- Conclusions -- REFERENCES -- 5 -- Hemodynamic Significance and Clinical Relevance of Delayed Cord Clamping and Umbilical Cord Milking -- Transitional Physiology and Animal Studies of Delayed Cord Clamping and Umbilical Cord Milking -- Cardiovascular Effects of Delayed Cord Clamping and Umbilical Cord Milking in the Delivery Room -- Hemodynamic Measurements in the First Hours After Birth Following Delayed Cord Clamping and Umbilical Cord Milking -- Neonatal Blood Volume After Delayed Cord Clamping and Umbilical Cord Milking -- Long-Term Outcomes and Mortality After Delayed Cord Clamping and Umbilical Cord Milking -- Conclusions and Future Directions -- REFERENCES -- 6 -- Transitional Hemodynamics and Pathophysiology of Peri/Intraventricular Hemorrhage -- Fetal and Transitional Circulation -- Cerebral Blood Flow -- Normal Changes in Cerebral Blood Flow -- Cerebral Blood Flow and Peri/Intraventricular Hemorrhage -- Vulnerabilities of Preterm Infants During Transition -- Inherent Vulnerability of the Immature Brain -- Immature Myocardium -- Hypovolemia and Timing of Cord Clamping -- Patent Ductus Arteriosus -- Hypotension -- Cardiorespiratory Interaction -- Hypocapnia and Hypercapnia -- Conclusions -- REFERENCES -- 7 -- The Immature Autonomic Nervous System, Hemodynamic Regulation, and Brain Injury in the Preterm Neonate -- Magnitude of the Problem -- Hemodynamic Vulnerability in Premature Infants -- The Premature Autonomic Nervous System -- The Premature Cardiovascular System -- Cerebral Hemodynamic Control in Premature Infants -- Evidence for an Association Between Systemic Hemodynamic Disturbances and Prematurity-Related Brain Injury.
Resolving the Relationship Between Systemic Hemodynamics and Prematurity-Related Brain Injury: Obstacles to Progress -- Measurement of Relevant Hemodynamic and Metabolic Indices -- Potential for "Dysmaturation" of the Autonomic Nervous System in Premature Newborns -- Conclusion -- REFERENCES -- 8 -- Pathophysiology of Persistent Pulmonary Hypertension of the Newborn-Cellular Basis and Lessons from Animal Studies -- Physiology of the Fetal Circulation -- Low Placental Vascular Resistance -- High Fetal Pulmonary Vascular Resistance -- Transition at Birth -- Animal Models of Pulmonary Hypertension in the Newborn -- Antenatal Ductal Ligation Model in Sheep With Reduced Pulmonary Blood Flow -- Cellular and Biochemical Changes -- Aortopulmonary Graft With Pulmonary Overcirculation -- Cellular and Biochemical Changes -- Drug Induced Pulmonary Hypertension -- Meconium Aspiration Model -- Chronic Hypoxia -- Monocrotaline-Induced Pulmonary Hypertension in Rats -- Intrauterine Growth Restriction -- Congenital Diaphragmatic Hernia -- Fetal Surgical Model in Lambs -- Cellular and Biochemical Changes -- Nitrofen Model in Rats -- Cellular and Biochemical Abnormalities -- Medications in Pregnancy and Persistent Pulmonary Hypertension of the Newborn: Cellular Basis -- Selective Serotonin Reuptake Inhibitors -- Nonsteroidal Antiinflammatory Drugs -- Antenatal Betamethasone -- Free Radicals in Persistent Pulmonary Hypertension of the Newborn -- Oxidative Stress -- Reactive Nitrogen Species -- Pathological Vascular Remodeling in Persistent Pulmonary Hypertension of the Newborn -- Cellular and Biochemical Basis of Various Persistent Pulmonary Hypertension of the Newborn Therapies -- Oxygen -- Human Data on Hypoxic Pulmonary Vasoconstriction -- Inhaled Nitric Oxide -- Attenuating Inactivation of Inhaled Nitric Oxide by Superoxide.
Soluble Guanylate Cyclase Stimulators and Activators (see Fig. 8.9) -- Inhibition of Phosphodiesterase 5 -- Hydrocortisone -- Inhibition of Phosphodiesterase 3 -- Cellular Basis for Emerging Therapies -- L-citrulline -- Rho-kinase inhibitors -- Stem Cell Therapies -- Conclusion -- Founding Sources -- REFERENCES -- 9 -- Pathophysiologically Based Management of Persistent Pulmonary Hypertension of the Newborn -- Pathophysiology, Hemodynamics and Treatment Targets -- Principles of Management of Persistent Pulmonary Hypertension of the Newborn -- Supportive Care -- Mechanical Ventilation and Surfactant -- Vasodilator Therapy in Persistent Pulmonary Hypertension of the Newborn -- Oxygen and Carbon Dioxide -- Inhaled Nitric Oxide -- Role of Inhaled Nitric Oxide in Preterm Oxygenation Failure -- Weaning Inhaled Nitric Oxide -- Other Pulmonary/Systemic Vasodilators -- Phosphodiesterase-5 Inhibitors -- Phosphodiesterase-3 Inhibitors -- Prostaglandins -- Endothelin Receptor Antagonists -- Magnesium Sulfate -- Utilizing Pathophysiology to Guide the Use of Vasodilators in Persistent Pulmonary Hypertension of the Newborn -- Vasopressor Therapy in Persistent Pulmonary Hypertension of the Newborn -- Using Pathophysiology to Guide Use of Vasopressors in Persistent Pulmonary Hypertension of the Newborn -- Extracorporeal Membrane Oxygenation -- Conclusions -- REFERENCES -- C -- Diagnosis of Neonatal Cardiovascular Compromise: Methods and Their Clinical Applications -- C1 -- Assessment of Systemic Blood Flow and Cardiac Function: Ultrasound -- 10 -- Point of Care Ultrasound in the Assessment of the Neonatal Cardiovascular System -- Politics of Ultrasound -- What's in a Name? -- Training and Accreditation in Point of Care Ultrasound -- Using Physiology to Target Treatment -- Uses of Point of Care Ultrasound in the Neonatal Intensive Care Unit.
[edited by] Istvan Seri ; consulting editor, Richard A. Polin.
Preceded by Hemodynamics and cardiology : neonatology questions and controversies / [edited by] Charles S. Kleinman, Istvan Seri ; consulting editor, Richard A. Polin. 2nd ed. c 2012.
Includes bibliographical references and index.