Autophagy and metabolism : potential target for cancer therapy.

Autophagy and Metabolism: Potential Target for Cancer Therapy presents updates on autophagy in cancer metabolism and how it can be used to develop new, more efficient treatments. Written by experts in the field, the book presents recent research and explains how to translate it to the clinical setti...

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Bibliographic Details
Corporate Author:	ScienceDirect (Online service)
Format:	eBook
Language:	English
Published:	London, United Kingdom ; Cambridge, MA : Elsevier, 2022.
Subjects:	Cancer > Treatment. Cell death. Neoplasms > metabolism Neoplasms > drug therapy Autophagy Antineoplastic Agents Drug Discovery Cancer > Traitement. Cellules > Mort. Autophagie (Cytologie) Anticancéreux. Cancer > Treatment Cell death Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Front Cover
Autophagy and Metabolism
Copyright Page
Contents
List of contributors
Preface
1 Metabolic dysregulation in cancer progression
1.1 Introduction
1.1.1 Hallmarks of dysregulated cancer metabolism
1.2 Impact of dysregulated metabolism on cancer progression
1.2.1 Dysregulated amino acid metabolism and effect on cancer progression
1.2.1.1 Arginine and tryptophan metabolism
1.2.1.2 Serine and glycine metabolism
1.2.1.3 Glutamine metabolism
1.2.1.4 Branched-chain amino acid metabolism
1.2.1.5 Role of long noncoding RNAs in regulating cancer amino acid metabolism
1.2.2 Dysregulated lipid metabolism and effect on cancer progression
1.2.3 Dysregulation of RNA metabolism: N6-methyladenosine (m6A) modification
1.2.4 Dysregulated mitochondrial metabolism and Warburg effect
1.3 Metabolic reprogramming for anchorage-independent growth, and to form metastatic tumors
1.4 Targeting dysregulated cancer metabolism: a therapeutic perspective
1.4.1 Antimetabolite chemotherapy, inhibitors of nucleotide synthesis, and antifolates
1.4.2 Repurposing common metabolic agents-vit C, vit D, aspirin, metformin
1.5 Conclusion
References
2 Molecular dynamics of autophagy in cancer metabolism
2.1 Introduction
2.2 Autophagy
2.2.1 Microautophagy
2.2.2 Chaperone-mediated autophagy
2.2.3 Macroautophagy
2.2.4 Metabolic reprogramming
2.2.5 Crosstalk between metabolic reprogramming and autophagy in carcinogenesis
2.3 Molecular mechanism of macroautophagy
2.3.1 Initiation
2.3.2 Nucleation
2.3.3 Maturation
2.3.4 Fusion and degradation
2.4 Autophagy regulation by metabolic stimuli
2.4.1 Nutrient starvation
2.4.2 Glucose
2.4.3 Amino acids
2.4.4 Lipids and free fatty acid
2.5 Molecular mechanism of autophagy regulation.
2.5.1 Target of rapamycin TOR/mammalian target of rapamycin
2.5.2 Phosphatidylinositol 3-kinase-I/ protein kinase B (PKB)
2.5.3 Beclin-1/phosphatidylinositol 3-kinase-III
2.5.4 Guanosine triphosphateases
2.5.5 Calcium
2.5.6 p53 and autophagy
2.5.7 Survivin and autophagy
2.6 Cancer regulation via autophagy
2.6.1 Tumor suppressor mechanism of autophagy
2.6.1.1 Oxidative stress and genetic instability
2.6.1.2 Necrosis and inflammation
2.6.2 Oncogenic mechanism of autophagy
2.6.2.1 Ras-dependent tumor progression
2.6.2.2 Ras-independent tumor progression
2.7 Therapeutics targeting autophagy
2.7.1 In vitro studies
2.7.2 Clinical trials
2.8 Conclusion
References
3 Tumor cell metabolism and autophagy as therapeutic targets
3.1 Introduction
3.2 Cancer metabolism in the tumor microenvironment
3.2.1 Cancer-associated fibroblasts
3.2.2 Endothelial cells
3.3 Metabolism of macrophages in tumor microenvironment
3.3.1 Tumor-associated macrophages metabolism in the proliferation of tumor cells
3.3.2 Effect of tumor-associated macrophages metabolism on the immune system
3.3.3 Tumor-associated macrophages and tumor cells
3.4 Altered metabolic enzymes
3.4.1 Glucose metabolism
3.4.2 Serine synthetic pathway
3.4.3 Glutamine and fatty acid metabolism
3.5 Role of autophagy in cancer
3.5.1 Cancer metabolism and autophagy
3.5.2 Autophagy as a therapeutic target
References
4 Autophagy regulation in cancer: current knowledge on action and therapy
4.1 Introduction
4.2 Regulation of autophagy
4.2.1 ATG12-ATG5-ATG16L complex
4.2.2 PABPC1-FAM134B-ER phagy pathway
4.2.3 Forkhead box K2
4.2.4 FKBP4/NR3C1/TMEM173 signaling pathway
4.2.5 Major histocompatibility complex class I
4.2.6 Sestrin 2 participates in autophagy induction.
6.1 Global arsenic scenario
6.2 Indian arsenic scenario
6.3 Bihar arsenic scenario
6.4 Cancer scenario
6.5 Disease cause
6.6 Autophagy in arsenic exposed population
6.7 Autophagy in cancer patients
6.8 Conclusion
References
7 Autophagy in cancer-associated fibroblasts: biology and targeting
7.1 Introduction
7.2 Cancer-associated fibroblast
7.2.1 Cancer-associated fibroblast identification
7.2.2 Source and heterogeneity in cancer-associated fibroblasts
7.2.3 Role of cancer-associated fibroblasts in cancer progression
7.3 Autophagy in cancer-associated fibroblast in cancer progression
7.3.1 Amino acid
7.3.2 Growth factor, cytokine, and chemokines
7.3.3 Autophagy maintains the cancer-associated fibroblast phenotype, keeping them from dedifferentiating to normal fibroblast
7.4 Targeting cancer-associated fibroblast autophagy for oncologic treatment
7.4.1 Targeting autophagy in current clinical trials for cancer treatment
7.4.2 Clinical trials targeting cancer-associated fibroblasts
Funding
References
8 Autophagy and metabolic regulation in cancer and its application in drug discovery
8.1 Introduction
8.2 Molecular mechanism of autophagy
8.3 Initiation of phagophore formation
8.4 Elongation
8.5 Maturation and fusion
8.6 Major autophagy-regulating targets
8.6.1 Autophagy and diseases
8.7 Autophagy and cancers
8.8 Mechanism of tumor suppression
8.9 Mechanism of tumor promotion
8.10 Therapeutic targets of autophagy in cancers
8.11 Conclusions and prospects
References
9 Mitophagy in cancer and cancer stem cells: a role in metabolic reprogramming
9.1 Introduction
9.2 Mitochondrial function and dynamics
9.3 Introduction to mitophagy
9.4 The mechanism of mitophagy
9.4.1 PINK1-Parkin-mediated mitophagy.
9.4.2 Alternative mitophagy mechanisms
9.5 Mitophagy and diseases
9.6 Mitophagy and cancer
9.6.1 The PINK1-PARKIN pathway in cancer
9.6.2 Role of mitochondrial fission and fusion in cancer
9.7 Mitophagy and cancer stem cells
9.8 Mitophagy in cancer stem cell drug-resistance
9.9 Concluding remarks
References
10 Combined targeting autophagy and metabolism for cancer therapy
10.1 Introduction
10.2 Autophagy: an introduction
10.3 Molecular mechanism of autophagy
10.4 Autophagy and cancer
10.5 Role of autophagy inducers in cancer therapy
10.6 Role of autophagy inhibitors in cancer therapy
10.7 Conclusion
References
11 Designing metabolic target-specific inhibitors for cancer therapy
11.1 Introduction
11.2 Role of metabolic target-specific inhibitors for cancer therapeutics
11.2.1 Glycolytic pathway targeted by novel anticancer drugs and phytochemicals
11.2.2 Effect of inhibitors on fatty acid metabolism
11.2.3 The therapeutic approach of phytochemicals toward the tricarboxylic acid cycle
11.2.4 De novo nucleotide biosynthesis and folate cycle inhibitors
11.2.5 Purine nucleotide synthesis
11.2.6 Pyrimidine nucleotide synthesis mechanism
11.2.7 Serine biosynthesis mechanism and Folate cycle
11.2.8 Tumor cells can tune the signal transduction pathways to allow synthesis of nucleotides
11.2.9 Advances in targeting the folate receptor
11.2.10 Metabolic inhibitors targeting urea cycle-methionine cycle
11.3 Conclusion
Conflict of Interest
Author contributions
Abbreviations
References
12 Interplay between gut microbiota and autophagy in human health
12.1 Autophagy
12.1.1 An overview of autophagy
12.1.2 Role of autophagy in gastrointestinal homeostasis
12.2 Gut microbiota
12.2.1 Technologies used to detect the gut microbiota.