Cause of pyloric stenosis of infancy /
The Cause of Pyloric Stenosis of Infancy chronicles the debate surrounding the cause of pyloric stenosis from its earliest discovery 300 years ago to the present.The Primary Hyperacidity Theory offers a credible explanation for all the classical signs and symptoms of pyloric stenosis as well a its a...
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| Format: | eBook |
| Language: | English |
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London :
Academic Press,
2021.
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| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Intro
- The Cause of Pyloric Stenosis of Infancy
- Copyright
- Dedication
- Contents
- Foreword
- Acknowledgments
- Introduction
- The first boy
- Reference
- Preamble
- Chapter 1 The early descriptions
- Overview
- The 1911 M.D. Thesis
- Early adjuvant diagnostic procedures
- References
- Chapter 2 The early theories of causation
- Were the retained stomach contents different in any way?
- References
- Chapter 3 History of medical treatment
- Medical treatment
- Antispasmodic drugs
- Dietary measures used to treat PS
- Other methods
- References
- Chapter 4 Early surgical treatment
- Preliminary jejeunostomy
- Gastro-enterostomy (GE)
- Divulsion of the pylorus (Nicoll-Loreta's operation)
- Pylorectomy
- Pyloroplasty (Heineke-Miculicz)
- Pyloroplasty leaving the mucosa intact (extra-mucosal)
- Dr. Pierre Fredet
- References
- Chapter 5 Ramstedt and beyond
- The UK experience
- England
- Scotland
- Contrasting surgical outcomes
- References
- Chapter 6 The alkalosis story
- Histamine, histamine receptors and H2 receptor blockade
- Alkalosis in PS and the search for the cause
- Professor Leonard Findlay, Pediatrician 1878-1947
- A moment in time
- References
- Chapter 7 The personal story
- How it was-Acid secretion physiology
- Where does pyloric stenosis of infancy come in?
- The helicobacter story and duodenal ulcer
- References
- Chapter 8 What makes the adult pyloric sphincter contract?
- The contribution from nerves
- The autonomic nervous system
- Non-adrenergic non-cholinergic nerves (NANC nerves)
- Purinergic nerves
- The nitric oxide story (NO)
- An overview
- Interstitial cells of Cahal (ICC)
- References
- Chapter 9 How does acid in the duodenum trigger sphincter contraction?
- Acid sensing-dependent processes in the gastrointestinal tract.
- Feedback control of gastric acid secretion
- The duodenal mucosal function
- Gastro-duodenal motility
- Molecular acid sensors
- Overview
- Prostaglandins
- Prostaglandins as a possible intermediary between duodenal hyperacidity and pyloric sphincter contraction
- References
- Chapter 10 Stomach motility and gastric emptying
- Motility of the adult stomach
- Function of the gastric reservoir
- Gastric emptying and the antral pump
- Gastric emptying
- Regulation elicited from stomach
- Regulation elicited from small intestine
- Interdigestive motility of stomach and small intestine
- Reference
- Chapter 11 The pyloric sphincter and pyloric stenosis of infancy
- References
- Chapter 12 Symptoms, signs and other clues
- The clinical clues
- The journey
- Neonatal gastrin and acidity
- References
- Chapter 13 Genetics-The seed and the soil
- References
- Chapter 14 The gastrin connection-Is it responsible for neonatal hyperacidity?
- References
- Further reading
- Chapter 15 The hesitant beginnings of the primary hyperacidity theory of cause
- The gastrin effect
- Is a narrowed pylorus enough to kick-start PS in real life?
- Do babies with PS have high gastrin levels?
- The sphincter and the agents which cause it to contract
- The feeding effect
- Feeding frequency and the effect
- References
- Chapter 16 The primary hyperacidity theory
- PS and acid secretion
- Sphincter thickness as a variable continuum
- The unexplained peaks in incidence
- Cholecystokinin (CCK) levels
- The puppy experiments
- Hyperacidity starts PS
- Physiology of acid secretion
- Acid-induced work hypertrophy as the cause
- The alleged histological abnormalities in PS
- The continuum theory
- The normal baby sphincter
- Unexplained peaks in incidence revisited
- Pyloromyotomy and falling mortality
- Erythromycin.
- The motilin story
- References
- Chapter 17 Clinical aspects and their explanation
- The clinical diagnosis
- Clinical questions resolved
- What makes some babies develop PS?
- Supporting evidence for hyperacidity as the cause
- Why male babies?
- Why self-cure with time?
- Overview
- Why is it more frequent in the first-born?
- Seasonal incidence
- Medical treatment
- The importance of relative underfeeding
- The African experience
- Two illustrative cases
- Why does the tumor disappear after pyloromyotomy and not after gastro-enterostomy?
- Why do symptoms appear at around 3-4 weeks of age?
- Neonatal PPI drugs-For good or ill
- References
- Further reading
- Chapter 18 The link between pyloric stenosis of infancy and duodenal ulcer in adults: Feedback-negative and positive
- Pyloric sphincter contraction
- Hyperacidity and hypertrophy-The connection
- The acid-producing consequences of pyloric sphincter hold-up
- What happens when gastric outlet obstruction (GOO) begins?
- Japanese contribution
- The link between pyloric stenosis of infancy and duodenal ulcer in adults
- The differences between duodenal ulcer and P.S.
- Conclusion
- References
- Chapter 19 Other contemporary lines of enquiry
- The genetic story
- Growth factors, chemical agents, and abnormalities of nerves
- The infection theories
- References
- Chapter 20 Conclusion
- References
- Chapter 21 The PS or reflux dilemma: Addendum 1
- Milk vomiting or regurgitation in the first 3 months of life
- Something old-something new
- The developmental process
- The pyloric stenosis (PS) of infancy connection
- How does this concern babies vomiting from an incompetent but normally placed cardia?
- Conclusion
- References
- Chapter 22 The real world: Addendum 2
- Index.