http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Studies in Natural Products Chemistry, Volume 70 covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, this book presents exciting opportunities in the field of new drug development to the pharmaceutical industry. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores.
Intro -- Bioactive Natural Products -- Copyright -- Contents -- Contributors -- Preface -- Chapter 1: HPLC-ESR-MS determination of the structures of radicals formed in the reaction of the antimalarial drug arte -- Introduction -- HPLC-ESR and HP LC-ESR-MS -- Determination of the structures of radicals formed in the reactions of hydroperoxides (or endoperoxides) with iron(II) ions ... -- Reaction of lipid-derived peroxides with iron(II) ions -- Reaction of 9-hydroperoxy-(10E,12E)-octadeca-10,12-dienoic acid (9EE-OOH) [or 13-hydroperoxy-(9Z,11E)-octadeca-9,11-dienoic ...
Possible reaction pathways for the formation of methyl and 1-methylethyl radicals -- Reaction of artemisinin with iron(II) ions -- Structure-activity studies of artemisinin and artemisinin-derived compounds -- Nonradical products formed through the cleavage of artemisinin, 1 with FeSO4 -- TEMPO or heme/tetraoxane-derived secondary C-centered radical adducts -- The determination of structures of radicals based on ESR hyperfine coupling constants -- The reaction mixture of artemisinin with iron(II) ions -- ESR analysis for the reaction of artemisinin with iron(II) ions
HPLC-ESR analyses of reaction mixtures of artemisinin, artemether, and artesunate -- HPLC-ESR-MS analyses of peaks 1-9 [56] -- Possible reaction pathways for the formation of artemisinin-, artemether- and artesunate-derived radicals -- Conclusion -- Acknowledgment -- Abbreviations -- References -- Chapter 2: Sensitive analysis of secondary metabolites in different lichen species using liquid chromatography-mass -- An introduction to lichens -- Ethnic and commercial uses of lichens -- Lichen in traditional medicine, and its biopharmaceutical potential
Secondary lichen metabolites: Unique as compared with other metabolites -- Current results on biological activities of secondary lichen metabolites -- Analysis of lichen metabolites: Recent trends -- Mass spectrometry in the analysis of lichen compounds -- LC-MS, a powerful analytical platform for the analysis of lichen compounds -- Limitations of LC-MS in lichen research and measures to expand the limits -- Structural characterization -- Lichen dereplication and screening -- LC-MS in lichen omics -- Quantification of lichen metabolites using LC-MS -- Conclusions -- Acknowledgments
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