http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Transport Proteins, Volume 123, provides the latest information on the two major groups of transport proteins, those that carry molecules to different locations within a cell or organism and those that carry molecules across otherwise impermeable membranes. Chapters in the updated release include Biology of Iron Transport: Ferroportin, Transport of transition metals across biological membranes, The effect of sport and physical activity on transport proteins: implications for cancer prevention and control, Structural rearrangement in polyketide synthase for improvement its bio-physicochemical properties, Autophagy Proteins and its Homeostasis in Cellular Environment, and much more.- Integrates experimental and computational methods for studying the structure and function of transport proteins and their implication in drug design- Contains timely chapters written by well-renowned authorities in their field- Includes a high number of top quality illustrations, figures and tables, and targets a very wide audience of specialists, researchers and students.
Front Cover -- Advances in Protein Chemistry and Structural Biology: Transport proteins -- Advances in Protein Chemistry and Structural Biology: Transport proteins -- Copyright -- Contents -- Contributors -- One -- Biology of the iron efflux transporter, ferroportin -- 1. Iron metabolism and the central role of ferroportin -- 1.1 Identification of ferroportin -- 2. Structure of ferroportin -- 3. Regulation of ferroportin -- 4. Disorders associated with ferroportin dysfunction -- 5. Ferroportin partners-molecules involved in efficient ferroportin functioning -- 6. Conclusion -- References
Two -- The effect of sport and physical activity on transport proteins: implications for cancer prevention and control -- 1. Transport proteins -- 2. Muscles -- 3. Muscle and transport proteins -- 4. Sport and transport proteins: implications for cancer treatment and prevention -- 5. Conclusions -- References -- Three -- Cancer bioenergetics as emerging holistic cancer theory: the role of metabolic fluxes and transport protein ... -- 1. Introduction -- 2. Cancer and bio-energetics: the emerging field of "onco-energetics" -- 3. Altered glycolysis and pyruvate oxidation metabolic fluxes in cancer
4. Altered glutamine metabolic fluxes in cancer -- 5. Altered serine metabolic fluxes in cancer -- 6. Altered TCA metabolism in cancer -- 7. Altered methionine metabolism in cancer -- 8. Altered tryptophan metabolism in cancer -- 9. Altered leucine metabolism in cancer -- 10. Altered ornithine metabolism in cancer -- 11. Altered proline metabolism in cancer -- 12. Altered acetate metabolism in cancer -- 13. Altered lipid metabolism in cancer -- 14. Mitochondrial structural and functional impairment -- 15. Tumor microenvironment -- 16. Nuclear DNA genes mutations -- 17. Cellular pathways mutations
18. Conclusions and future prospects -- References -- Four -- Investigating mutations at the hotspot position of the ERBB2 and screening for the novel lead compound to tr ... -- 1. Introduction -- 2. Materials and methods -- 2.1 Database for prevalence mutations in breast cancer -- 2.2 Pathogenicity and stability prediction tools -- 2.3 Amino acid conservation analysis -- 2.4 Lipinski's rule -- 2.5 Molecular docking -- 2.6 Protein dynamics simulation -- 3. Results -- 3.1 Mutation prevalence -- 3.2 Pathogenicity and stability analysis -- 3.3 Conservation analysis -- 3.4 Protein dynamics simulations
Advances in protein chemistry and structural biology ; v. 123