http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Ph-interfering agents as chemosensitizers in cancer therapy
Intro -- pH-Interfering Agents as Chemosensitizers in Cancer Therapy -- Copyright -- Cover Image Insert -- Aims and scope for series``Cancer sensitizing agents for chemotherapy ́́ -- About the Series Editor -- Aims and Scope of the Volume -- About the Volume Editors -- Preface -- Contents -- Contributors -- Part I: General overview of the topic: An update -- Chapter 1: Tumors and their microenvironment -- Introduction -- The role of tumor microenvironment -- Cancer-associated fibroblasts (CAFs) -- Angiogenic vascular cells -- Immune infiltrating cells -- ECM within the microenvironment
Hypoxia and acidity -- References -- Chapter 2: pH regulators of the tumoral microenvironment: A general overview -- Introduction -- MCT1 and MCT4 -- Carbonic anhydrases -- NHE1 -- Sodium bicarbonate cotransporters and anion exchangers -- pH metabolons -- Effect of inhibiting pH regulators on migration, invasion, and metastasis -- Effect of inhibiting pH regulation on response to chemotherapy -- pH and mitochondria -- Conclusions -- References -- Chapter 3: Use of pH-interfering agents as chemosensitizers: Clinical studies survey -- Carbonic anhydrases -- Proton pump inhibitors
Monocarboxylate transporters -- Ionophores -- Other pH-interfering agents -- Conclusion -- Acknowledgments -- References -- Part II: pH-Interfering agents as chemosensitizers -- Chapter 4: Proton pump inhibitors and other pH-buffering agents -- Introduction -- Tumor acidity and chemoresistance -- V-ATPases and proton pump inhibitors -- Preclinical data supporting the use of proton pump inhibitors in cancer treatment -- Clinical outcomes of proton pump inhibitors in association to anticancer therapies -- Monocarboxylate transporter (MCT) inhibitors
Inhibitors of Na+/H+ exchanger (NHE), Na+/HCO3- cotransporter (NBC), and anion exchanger (AE) -- Conclusions -- References -- Chapter 5: Design, synthesis, and biological evaluation of selective hCA IX inhibitors -- Introduction -- Antibodies and antibody fragments which target CA IX -- Small molecules which target CA IX -- Conclusion -- References -- Chapter 6: Small molecules and monoclonal antibodies as selective hCA XII inhibitors: An update -- Introduction -- Small molecules and monoclonal antibodies as selective hCA XII inhibitors -- Differences in the active site of hCA IX and XII
Recent sulfonamide derivatives as (selective) hCA XII inhibitors -- Coumarins and their derivatives as hCA XII inhibitors -- Drug repurposing and polypharmacology as innovative approaches to discover selective hCA XII inhibitors -- Monoclonal antibodies as very selective hCA XII inhibitors -- Conclusion -- References -- Chapter 7: Efflux pumps, NHE1, monocarboxylate transporters, and ABC transporter subfamily inhibitors -- Introduction -- Classes of transporters and efflux pumps -- Solute carrier class (SLC) transporters -- Monocarboxylate transporters -- MCT expression in normal tissues
edited by Claudiu T. Supuran and Simone Carradori.
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