rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Ph-interfering agents as chemosensitizers in cancer therapy
  name:
    name part: Supuran, Claudiu T.
  name:
    name part: Carradori, Simone.
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: Electronic books.
  genre: Internet Resources.
  genre: Index not Present.
  origin info:
    place:
      place term: enk
    place:
      place term: London
    publisher: Academic Press
    date issued: [2021]
    date issued: 2021
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource
  table of contents: Intro -- pH-Interfering Agents as Chemosensitizers in Cancer Therapy -- Copyright -- Cover Image Insert -- Aims and scope for series``Cancer sensitizing agents for chemotherapy ́́ -- About the Series Editor -- Aims and Scope of the Volume -- About the Volume Editors -- Preface -- Contents -- Contributors -- Part I: General overview of the topic: An update -- Chapter 1: Tumors and their microenvironment -- Introduction -- The role of tumor microenvironment -- Cancer-associated fibroblasts (CAFs) -- Angiogenic vascular cells -- Immune infiltrating cells -- ECM within the microenvironment
  table of contents: Hypoxia and acidity -- References -- Chapter 2: pH regulators of the tumoral microenvironment: A general overview -- Introduction -- MCT1 and MCT4 -- Carbonic anhydrases -- NHE1 -- Sodium bicarbonate cotransporters and anion exchangers -- pH metabolons -- Effect of inhibiting pH regulators on migration, invasion, and metastasis -- Effect of inhibiting pH regulation on response to chemotherapy -- pH and mitochondria -- Conclusions -- References -- Chapter 3: Use of pH-interfering agents as chemosensitizers: Clinical studies survey -- Carbonic anhydrases -- Proton pump inhibitors
  table of contents: Monocarboxylate transporters -- Ionophores -- Other pH-interfering agents -- Conclusion -- Acknowledgments -- References -- Part II: pH-Interfering agents as chemosensitizers -- Chapter 4: Proton pump inhibitors and other pH-buffering agents -- Introduction -- Tumor acidity and chemoresistance -- V-ATPases and proton pump inhibitors -- Preclinical data supporting the use of proton pump inhibitors in cancer treatment -- Clinical outcomes of proton pump inhibitors in association to anticancer therapies -- Monocarboxylate transporter (MCT) inhibitors
  table of contents: Inhibitors of Na+/H+ exchanger (NHE), Na+/HCO3- cotransporter (NBC), and anion exchanger (AE) -- Conclusions -- References -- Chapter 5: Design, synthesis, and biological evaluation of selective hCA IX inhibitors -- Introduction -- Antibodies and antibody fragments which target CA IX -- Small molecules which target CA IX -- Conclusion -- References -- Chapter 6: Small molecules and monoclonal antibodies as selective hCA XII inhibitors: An update -- Introduction -- Small molecules and monoclonal antibodies as selective hCA XII inhibitors -- Differences in the active site of hCA IX and XII
  table of contents: Recent sulfonamide derivatives as (selective) hCA XII inhibitors -- Coumarins and their derivatives as hCA XII inhibitors -- Drug repurposing and polypharmacology as innovative approaches to discover selective hCA XII inhibitors -- Monoclonal antibodies as very selective hCA XII inhibitors -- Conclusion -- References -- Chapter 7: Efflux pumps, NHE1, monocarboxylate transporters, and ABC transporter subfamily inhibitors -- Introduction -- Classes of transporters and efflux pumps -- Solute carrier class (SLC) transporters -- Monocarboxylate transporters -- MCT expression in normal tissues
  note: edited by Claudiu T. Supuran and Simone Carradori.
  subject:
    topic: Cancer
    topic: Chemotherapy
  subject:
    topic: Cancer
    topic: Treatment
    topic: Technological innovations
  subject:
    topic: Oncology
  subject:
    topic: Medical Oncology
  subject:
    topic: Neoplasms
  subject:
    topic: Neoplasms
    topic: drug therapy
  subject:
    topic: Cancer
    topic: Chimiothérapie
  subject:
    topic: Cancérologie
  subject:
    topic: Oncology
  subject:
    topic: Cancer
    topic: Chemotherapy
  subject:
    topic: Cancer
    topic: Treatment
    topic: Technological innovations
  classification: RC271.C5
  classification: 616.994061
  related item:
    title info:
      title: Ph-interfering agents as chemosensitizers in cancer therapy
    origin info:
      publisher: London : Academic Press, [2021]
    identifier: (OCoLC)1135670406
  related item:
    title info:
      title: Cancer sensitizing agents for chemotherapy ; 10
  identifier: 9780128209288
  identifier: 0128209283
  identifier: 9780128207017
  identifier: 9780128209288 Ingram Content Group
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: YDX
    record creation date: 200909
    record change date: 20260327165224.5
    record identifier: in00005767072
    language of cataloging:
      language term: eng