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Schering Workshop on Pharmacokinetics, Berlin, May 8 and 9, 1969
Schering Workshop on Pharmacokinetics (1969 : Berlin)
Advances in the Biosciences 5: Schering Workshop on Pharmacokinetics, Berlin, May 8 and 9, 1969 is a collection of papers presented at the Schering Workshop on Pharmacokinetics held in Berlin, Germany, on May 8 and 9, 1969. Contributors focus on advances in the field of pharmacokinetics, including the use of digital computers in defining pharmacokinetic parameters and of mathematical models in the study of steroid dynamics. The pharmacokinetics of acetazolamide and endogenous substances is also described. This book is comprised of 19 chapters and begins with an overview of the basic concepts a.
Front Cover; Advances in the Biosciences 5; Copyright Page; Table of Contents; Chapter 1. Introduction; Chapter 2. Opening; What is Pharmacokinetics?; Additional Remark; Chapter 3. Basic Concepts and Experimental Methods of Pharmacokinetics; Philosophical basis of pharmacokinetics; Basic concepts; Experimental methods; References; Discussion; Chapter 4. General Physico-Chemical Aspects of DrugDistribution; 1. General factors governing the transport of material in biologicalsystems; 2. On the influence of membrane solubility (partition
3. The transport of ionic compounds across a fixed charge membrane4. Diffusion with superposed convection (water streaming); Some critical remarks; 5. Some considerations of passive and active transport; Chapter 5. Multiple Dose Elimination Kinetics and Drug Accumulation in Patients with Normal and with Impaired Kidney Function; Intermittent administration; The time-course of accumulation; Contineous administration; Calculation of the initial dose; The elimination of drugs in patients with impaired kidney function; The dosage of drugs in patients with impaired kidney function; References
DiscussionChapter 6. The Application of the Analog Computer inPharmacokinetics; Introduction; imulation of the pharmacokinetics of steroid drugs; References; Discussion; Chapter 7. Use of Digital Computers in Defining PharmacokineticParameters; 1. Introduction; 2. Mathematical model making; 3. Objectives of model making; 4. Adaptive aspects; 5. Computational solution; 6. Simulation; 7. Identification process; 8. Quasilinearization; 9. Discussion; 10. Alternate identification procedure; 11. Conclusion; References; Discussion
Chapter 8. Use of Mathematical Tools in DefiningPharmacokinetic ParametersReferences; Discussion; Chapter 9. Mathematical and Statistical Problems in Pharmacokinetics; A. Introduction; B. The mathematical foundations of compartmental models; C. Statistical problems; Chapter 10. The Formulation of Models to explain Blood andTissue Data on Distribution of Drugs and Tracers(With special Reference to Multi-CompartmentModels); Introduction; The notion of compartment; Some examples of multi-compartmental models; The mathematical formulation of multi-compartment models
Assessment of compartments and compartment analysisConcluding Remark; Chapter 11. An Explicit Function for Rate Constant ofEntrance Concerning a Two-Compartment-Model; 1. Problem; 2. Solution; 3. Procedure; 4. Discussion; Chapter 12. Mathematical Models in the Study of SteroidDynamics; Chapter 13. The Measurement of Enteric Absorption Rateusing a Double Tracer Technique; Introduction; The concept of occupancy and the occupancy principle; Measurement of enteric absorption; Practical examples; The Systematic Influence of Elimination; Introduction
editor, Gerhard Raspé ; cover design, Herbert W. Kapitzki.
Disturbances of elimination caused by the pathological state of theorgans
Includes bibliographical references at the end of each chapters.