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Progress in molecular biology and translational science. Volume 160 /

Progress in Molecular Biology and Translational Science, Volume 160 provides the most topical, informative and exciting monographs available on a wide variety of research topics related to prions, viruses, bacteria and eukaryotes. The series gives in-depth knowledge on the important molecular biolog...

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Bibliographic Details
Corporate Author: ScienceDirect (Online service)
Other Authors: Teplow, David B. (Editor)
Format: eBook
Language:English
Published: Cambridge, Massachusetts : Academic Press, 2018.
Series:Progress in molecular biology and translational science ; 160.
Subjects:
Molecular biology.
Biologie moléculaire.
molecular biology.
SCIENCE > Life Sciences > Biochemistry.
Molecular biology
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Front Cover
  • Progress in Molecular Biology and Translational Science
  • Copyright
  • Contents
  • Contributors
  • Preface
  • Chapter One: Adult Stem Cells for Regenerative Therapy
  • 1. Introduction
  • 2. Adult Stem Cells Therapy for the Heart
  • 2.1. Skeletal Myoblasts
  • 2.2. Bone Marrow-Derived Cells
  • 2.3. Stem Cells From Heart
  • 2.4. Induced Pluripotent Stem Cells
  • 3. Adult Stem Cell Therapy for Neurogenesis
  • 3.1. Adult Stem Cell Therapy for Cerebral Palsy
  • 3.2. Adult Stem Cell Therapy for Stroke
  • 3.3. Adult Stem Cell Therapy for Blood Disorders
  • 4. Adult Stem Cell Therapy for Diabetes Mellitus
  • 5. Stem Cell Therapy for the Ophthalmic Disorders
  • 6. Challenges and Future Direction
  • 7. Concluding Remarks
  • Acknowledgments
  • References
  • Chapter Two: Hair Follicle-Associated Pluripotent(HAP) Stem Cells
  • 1. Introduction
  • 2. HAP Stem Cells
  • 3. Growth of Nerves in Histoculture From HAP Stem Cells
  • References
  • Further Reading
  • Chapter Three: Fluorescent Proteins as Sensors for Cellular Behavior in Mice
  • 1. Properties of GFP and Other Fluorescent Proteins as Imaging Agents
  • 2. Intravital Imaging Using Fluorescent Proteins
  • 3. Cancer Cell Trafficking in Blood Vessels
  • 4. Cancer Cell Trafficking in Lymphatic Channels Imaged With RFP and RFP
  • 5. Cancer Neurogenesis
  • 6. Metastatic Route Mapping at the Single-Cell Level in Real Time
  • 7. Comparison of Orthotopically- and Subcutaneously- Transplanted Tumors at the Cellular Level
  • 8. Other Metastatic Models Imaged With GFP
  • 9. Brain Metastasis
  • 10. Role of Stroma and Other Host Cells in Metastasis
  • 11. Imageable Color-Coded Tumor-Host Models
  • 12. Imaging Quiescent or Dormant Cancer Cells
  • 13. New In Vivo GFP Imaging Technology
  • 14. Conclusions
  • References
  • Chapter Four: Arrestins: Introducing Signaling Bias Into Multifunctional Proteins.
  • 1. Wild-Type Arrestins: Too Many Functions
  • 2. Receptor Specificity: Selective Targeting of Certain GPCRs?
  • 3. Making Arrestins Phosphorylation Independent
  • 4. Channeling the Signaling Toward or Away From Selected Pathways
  • 5. ``Designer Arrestins": A Roadmap or a Dream?
  • Acknowledgments
  • References
  • Chapter Five: Analysis of Biased Agonism
  • 1. Introduction
  • 2. A single-Receptor View of Drug Action
  • 3. Relationship Between the Simple Receptor-State Model and Agonist-Receptor-G Protein Interactions
  • 4. Relationship Between the Receptor-State Parameters and the More Conventional Parameters of the Receptor Population, Af ...
  • 5. General Strategy for Estimating Receptor-State Parameters From Functional Data
  • 6. Examples of Experimental Paradigms and Methods of Analysis
  • 6.1. Experimental Paradigms for the Estimation of Receptor-State Affinity Constants
  • 6.2. Using Receptor-State Parameters to Estimate Population Parameters
  • 6.3. Example of Population Analysis and Its Relation to Receptor-State Analysis
  • 7. Interpretation of Receptor-State and Population Analysis Within the Context of Agonist Bias
  • 8. Establishment and Standardization of Quantitative In Vitro and In Vivo Assays for Drug Screening
  • References
  • Chapter Six: Effects of Estrogens on Central Nervous System Neurotransmission: Implications for Sex Differences in Mental ...
  • 1. Introduction
  • 1.1. Central Neurotransmitters Regulate Mood, Reward, and Motivation
  • 1.2. Dysregulation of Neurotransmission Leads to Mental Disorders
  • 1.3. Sex Differences in CNS Neurotransmission-Related Mental Disorders
  • 1.4. Aim and Focus of This Chapter
  • 2. CNS Neurotransmission Involved in Reward Circuitry
  • 2.1. Structurally Interconnected Circuitry
  • 2.2. Human and Animal Models.
  • 2.3. More Studies Including Female Subjects and Studying Sex Differences Are Needed
  • 2.4. Sex Differences in the CNS Regulated by Sex Hormones
  • 2.4.1. Organizational and Activational Effects of Estrogens
  • 2.4.2. Effects of Estrogens on Tissues and Cells
  • 2.4.3. Actions of Estrogens via ERs
  • 2.4.3.1. Estrogen Genomic Actions via Nuclear ERs
  • 2.4.3.2. Estrogen Nongenomic Actions via Membrane ERs
  • 3. Effects of Estrogens on CNS Neurotransmission
  • 3.1. Overview of Effects of Estrogens on Neurotransmission-Mediated CNS Circuitry
  • 3.2. Sex Differences and Modulation of Dopaminergic Pathway by Estrogens
  • 3.2.1. Dopaminergic Pathway
  • 3.2.2. Sex Differences and Modulation of DA Pathway by Estrogens-Human Studies
  • 3.2.3. Sex Differences and Modulation of DA Pathway by Estrogens-Animal Studies
  • 3.2.4. Underlying Mechanisms of Modulation of DA Pathway by Estrogens
  • 3.2.4.1. Effects of Estrogens on Sexual Differentiation
  • 3.2.4.2. Effects of Estrogens on DA Neurotransmission
  • 3.3. Sex Differences and Modulation of Serotonergic Pathway by Estrogens
  • 3.3.1. Serotonergic Pathway
  • 3.3.2. Sex Differences and Modulation of 5HT Pathway by Estrogens-Human Studies
  • 3.3.3. Sex Differences and Modulation of 5HT Pathway by Estrogens-Animal Studies
  • 3.3.4. Underlying Mechanisms of Modulation of 5HT Pathway by Estrogens
  • 3.4. Sex Differences and Modulation of Glutamatergic and GABAergic Pathways by Estrogens
  • 3.4.1. Glutamatergic and GABAergic Pathways
  • 3.4.2. Sex Differences and Modulation of Glutamatergic and GABAergic Pathways by Estrogens-Cell Culture and Animal Studies
  • 3.4.3. Underlying Mechanisms of Modulation of Glutamatergic and GABAergic Pathways by Estrogens
  • 3.5. Sex Differences and Modulation of Endocannabinoid Pathway by Estrogens
  • 3.5.1. Endocannabinoid Pathway.
  • 3.5.2. Sex Differences and Modulation of Endocannabinoid Pathway by Estrogens-Human Studies
  • 3.5.3. Sex Differences and Modulation of Endocannabinoid Pathway by Estrogens-Animal Studies
  • 3.5.4. Underlying Mechanisms of Modulation of Endocannabinoid Pathway by Estrogens
  • 4. Conclusions
  • Acknowledgments
  • References
  • Index
  • Back Cover.