Structure and function of calcium release channels /
This volume of Current Topics in Membranes focuses on Membrane Protein Crystallization, beginning with a review of past successes and general trends, then further discussing challenges of mebranes protein crystallization, cell free production of membrane proteins and novel lipids for membrane protei...
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| Format: | eBook |
| Language: | English |
| Language Notes: | English. |
| Published: |
Amsterdam :
Academic,
2010.
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| Series: | Current topics in membranes ;
66. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Front Cover; Current Topics in Membranes; Copyright Page; Contents; Contributors; Preface; Previous Volumes in Series; Section 1: RYR Ca2+ Release Channels; Chapter 1: RyRs: Their Disposition, Frequency, and Relationships with Other Proteins of Calcium Release Units; I. Overview; II. Introduction; III. Cardiac CRUs; IV. CRUs in Skeletal and Invertebrate Body Muscles; V. Factors Affecting CRU Assembly in Skeletal and Cardiac Muscles; VI. Isoform-Specific Features of RyR Distribution; VII. Architecture of SR and T Tubule Membranes is Muscle- and Fiber-Type Specific; Acknowledgments; References
- Chapter 2: Electron Microscopy of Ryanodine ReceptorsI. Overview; II. Introduction; III. Cryo-EM of Macromolecular Complexes; IV. Three-Dimensional Architecture of RyR as Determined by Cryo-EM; V. a-Helices in the TM Region and the Mechanism of Calcium Channel Gating; VI. Synergism of 3D Cryo-EM and Other Biophysical/Biochemical Techniques; VII. Outlook and Perspectives; References; Chapter 3: The Ryanodine Receptor Pore: Is There a Consensus View?; I. Overview; II. Introduction; III. Ion Handling in RyR; IV. Where is the PFR in the RyR Channel?
- v. Attempts to Identify the Structure of the RyR PFRVI. Theoretical Approaches to Understanding the Mechanisms Underlying Ion Translocation and Discrimination in RyR; VII. Testing Physical and Theoretical Models of the RyR PFR by Residue Substitution; VIII. Concluding Remarks; Acknowledgments; References; Chapter 4: Regulation of RyR Channel Gating by Ca2+, Mg2+ and ATP; I. Overview; II. Introduction; III. RyR2 in Cardiac Contraction and Pacemaking; IV. Four Ca2+ Sensing Mechanisms for RyR2; V. Synergistic Ca2+-Activation via Cytoplasmic and Luminal Facing Binding Sites
- VI. Channel Open Times and the Role of Ca2+ Feed-ThroughVII. Three Mechanisms for Mg2+-Inhibition of RyR2; VIII. A Model for Ca2+ and Mg2+ Regulation of RyR2; IX. Adenine Neucleotides; X. Regulation of RyR2 in Cardiac E-C Coupling; XI. Concluding Remarks; Acknowledgments; References; Chapter 5: Regulation of Ryanodine Receptor Ion Channels Through Posttranslational Modifications; I. Overview; II. Introduction; III. RyR1 and RyR2 Phosphorylation; IV. RyR Modulation by Reactive Oxygen and Nitrogen Species; V. Conclusions; Acknowledgment; References
- Chapter 6: Crosstalk via the Sarcoplasmic Gap: The DHPR-RyR InteractionI. Overview; II. DHPR and RyR Arrangement in Skeletal and Cardiac Muscle Membranes-Basis for Differences in the EC Coupling Mechanism; III. Structural Domains Involved in skDHPR-RyR1 Interaction; IV. The Role of Intracellular Molecular Regions Besides the a1S II-III Loop in skDHPR-RyR1 Interaction; V. Intracellular Molecular Regions of a1S Involved in Tetrad Formation; VI. The Role of the Accessory skDHPR Subunits in Interaction with RyR1; VII. Conclusion; References; Chapter 7: Ryanodinopathies: RyR-Linked Muscle Diseases