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GABAb receptor pharmacology : a tribute to Norman Bowery /

This monograph was assembled to honor Professor Norman Bowery and his work on the 30th anniversary of his discovery of the GABAB receptor. In the present volume, leading neuroscientists from academia and industry provide a perspective of current research, both basic and translational, in the discove...

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Bibliographic Details
Corporate Author: ScienceDirect (Online service)
Other Authors: Blackburn, Thomas
Format: eBook
Language:English
Language Notes:English.
Published: Amsterdam ; Boston : Elsevier, 2010.
Edition:1st ed.
Series:Advances in pharmacology,
Subjects:
Bowery, N. G.
GABA > Receptors.
Pharmacology.
Receptors, GABA-B > chemistry
Receptors, GABA-B > physiology
gamma-Aminobutyric Acid > pharmacology
Pharmacology
Pharmacologie.
pharmacology.
MEDICAL > Pain Medicine.
MEDICAL > Psychiatry > Psychopharmacology.
GABA > Receptors
Electronic books.
Festschriften
Festschriften.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Cover; GABAB Receptor Pharmacology: A Tribute to Norman Bowery; Copyright; Contents; Contributors; Preface; Historical Perspective and Emergence of the GABAB Receptor; Abstract; I. Introduction; II. GABAB Receptor Ligands; III. Receptor Distribution; IV. Allosteric Modulation; V. Receptor Function; VI. Potential Therapeutic Significance; VII. Conclusion; References; Chemistry and Pharmacology of GABAB Receptor Ligands; Abstract; I. Introduction; II. GABAB Receptor Agonists; III. GABAB Receptor Partial Agonists; IV. Positive Modulators of GABAB Receptors; V. GABAB Receptor Antagonists
  • VI. ConclusionAcknowledgments; List of Nonstandard Abbreviations; References; Heterodimerization of the GABAB Receptor-Implications for GPCR Signaling and Drug Discovery; Abstract; I. Introduction; II. Identification of the GABAB Receptors; III. The Phylogeny of GABAB Receptors GABAB Receptors in DifferentSpecies; IV. Structure of GABAB Receptors; V. Function of the GABAB Receptor Heterodimer; VI. GABAB as a Model System for GPCR Dimerization; VII. Conclusions; Abbreviations; References; Mechanisms of GABAB Receptor Exocytosis, Endocytosis, and Degradation; Abstract; I. Introduction
  • II. Cell-Surface Trafficking of GABAB ReceptorsIII. Endocytosis of GABAB Receptors; IV. Degradation of GABAB Receptors; V. Conclusions; Acknowledgments; Abbreviations; References; Functional Modulation of GABAB Receptors by ProteinKinases and Receptor Trafficking; Abstract; I. Introduction; II. Phosphorylation of GABABR and Its Functional Modulation; III. Phosphorylation-Independent Desensitization of GABABRs by ProteinKinases; IV. GABABR Endocytic Sorting and the Control of Receptor Cell SurfaceStability; V. GABABR Phosphorylation and Diseases; VI. Conclusion; Acknowledgments; Abbreviations
  • III. Possible Ligands for GABABR in Cerebellar Purkinje CellsIV. Functions of GABABR Near the Excitatory Synapses; V. Possible Physiological Significance of GABABR-Mediated Effects onmGluR1 Signaling; VI. Conclusion; Acknowledgments; Non-standard abbreviations; References; GABA Transporter GAT1: A Crucial Determinant of GABAB Receptor Activation in Cortical Circuits?; Abstract; I. Introduction; II. The Plasma Membrane GABA Transporter; III. Cellular and Subcellular Localization of GABABRsand GAT1; IV. GABABR Activation by GABA Released from EndogenousSources