rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Delivery of therapeutics for biogerontological interventions
    sub title: from concepts to experimental design
  name:
    name part: Lai, Wing-Fu.
    role:
      role term: creator
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: enk
    place:
      place term: London
    publisher: Academic Press
    date issued: 2019
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource
  table of contents: Front Cover; Delivery of Therapeutics for Biogerontological Interventions; Copyright Page; Contents; Foreword; Preface; Abbreviations; I. From Concepts to Plans; 1 Theoretical frameworks for intervention development; Introduction; A reductionist approach to understand aging; Reliability theory of aging; Hypothetical frameworks for tackling aging; Reasons for the failure of an intervention; Summary; References; 2 Available delivery technologies for intervention execution; Introduction; Use of delivery technologies in interventions; Advances in delivery of nucleic acids
  table of contents: Nucleic acid delivery mediated by biological meansNucleic acid delivery mediated by chemical and physical means; Advances in delivery of nongenetic materials; Integration of engineering techniques into therapeutics delivery; Summary; References; II. From Plans to Technologies; 3 Design of viral vectors for genetic manipulation; Introduction; Engineering the properties of a viral vector; Chemical manipulation for controlled delivery; Applications in genetic manipulation; Opportunities and challenges; Summary; References; 4 Design of polymeric vectors for genetic manipulation; Introduction
  table of contents: Selection of polymeric vectorsStructural modification of polymeric vectors; Copolymerization; Functional group modification; Ligand conjugation; Optimization for intervention execution; Summary; References; 5 Design of cyclodextrin-based systems for intervention execution; Introduction; Basic properties of cyclodextrins; Strategies for structural engineering of cyclodextrins; Roles in vector design; Cyclodextrin incorporation for multifunctionality; Manipulation of host-guest complexation; Summary; References; 6 Design of upconversion nanoparticles for intervention execution; Introduction
  table of contents: Major designing principlesFabrication and morphological manipulation of upconversion nanoparticles; Generation of upconversion nanoparticle-based nucleic acid carriers; Roles of upconversion nanoparticles in nucleic acid delivery; Light-mediated control of intervention execution; Imaging and tracking of the delivery process; Optimization of upconversion nanoparticle-based nucleic acid carriers; Improvement in upconversion nanoparticle fabrication; Summary; References; 7 Design of hydrogel-based nanoparticles for intervention execution; Introduction; Development of hydrogels for drug delivery
  table of contents: Design of hydrogels for intervention developmentGeneration of hydrogel nanoparticles; Ring-opening polymerization; Aqueous dispersion polymerization; Emulsion polymerization; Methods for drug loading; Strategies for cargo loading; Factors influencing the loading efficiency; Modulation of drug release; Summary; References; III. From Technologies to Interventions; 8 Use of delivery technologies to mediate RNA degradation; Introduction; Manipulation of the aging network by RNAi; Enhancement of the siRNA performance; Delivery of siRNA therapeutics; Clinical use of siRNA therapeutics
  note: Wing-Fu Lai.
  note: Includes bibliographical references and index.
  subject:
    topic: Geriatric pharmacology
  subject:
    topic: Drug delivery systems
  subject:
    topic: Life expectancy
  subject:
    topic: Drug Delivery Systems
  subject:
    topic: Aging
    topic: physiology
  subject:
    topic: Life Expectancy
  subject:
    topic: Geriatrics
    topic: methods
  subject:
    topic: Pharmacologie gériatrique
  subject:
    topic: Systèmes d'administration de médicaments
  subject:
    topic: Espérance de vie
  subject:
    topic: Life expectancy
  subject:
    topic: Drug delivery systems
  subject:
    topic: Geriatric pharmacology
  classification: RC953.7
  classification: 615.1
  classification: 2019 H-606
  classification: QV 785
  related item:
    identifier: (OCoLC)1089004236
  identifier: 9780128172766
  identifier: 0128172762
  identifier: 0128164859
  identifier: 9780128164853
  identifier: 9780128172766 Ingram Content Group
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: YDX
    record creation date: 190728
    record change date: 20260327163227.8
    record identifier: in00005765187
    language of cataloging:
      language term: eng