Glycosaminoglycans in development, health and disease /
Glycosaminoglycans (GAGs) are a family of linear polysaccharides that are found in all animal tissues. Several are used as biomaterials, including heparin, heparin sulfate, keratan sulfate, dermatan sulfate, and chondroitin sulfate. This volume discusses the role of GAGs in development, health and d...
| Main Author: | |
|---|---|
| Corporate Author: | |
| Format: | eBook |
| Language: | English |
| Language Notes: | English. |
| Published: |
Amsterdam :
Elsevier,
2010.
|
| Series: | Progress in molecular biology and translational science ;
v. 93. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Front Cover; Progress in Molecular Biology and Translational Science: Glycosaminoglycans in Development, Health and Disease; Copyright page; Contents; Contributors; Preface; Glycosaminoglycan (GAG) Biosynthesis and GAG-Binding Proteins; I. Glycosaminoglycans (GAGs); II. Proteoglycan; III. GAG Biosynthesis; IV. GAG-Binding Proteins; V. Concluding Remarks; References; Mice Deficient in Glucuronyltransferase-I; I. Introduction; II. GlcAT-I Gene Structure; III. cDNA and Protein Structure of GlcAT-I; IV. Enzymatic Activities; V. Homologous Proteins; VI. Expression Pattern of GlcAT-I
- VII. GlcAT-I in Mouse Early EmbryogenesisVIII. Concluding Remarks; References; Mice Deficient in Heparan Sulfate N-Deacetylase/N-Sulfotransferase 1; I. Introduction; II. Gene and Protein Structure; III. Homologues; IV. Enzymatic Activities; V. Heparan Sulfate Structure in Ndst1 Deficient Embryos; VI. Effects of Ndst1 Deficiency During Development; VII. Effects of Ndst1 Deficiency in Adult Mice; VIII. Concluding Remarks; References; Glucuronyl C5-Epimerase; I. Introduction; II. Molecular Biology of HSepi; III. Transformation-Related Phenotypes Attributable to HSepi
- IV. Regulation of the Gene ExpressionV. Industrial Applications of HSepi; VI. Concluding Remarks; References; Mice Deficient in Heparan Sulfate 6-O-Sulfotransferase-1; I. Introduction; II. Characterization of Heparan Sulfate 6-O-Sulfotransferases; III. HS6ST-1-Deficient Mice Exhibit Defective HS Biosynthesis, Abnormal Placentation and Organ Morphogenesis, and Late Embryon; IV. Function of HS6ST in Other Organisms; V. Hs6st-1-/Hs6st-2-Deficient Fibroblasts Regulate Differentially the Signaling Induced with Various FGFs59; References
- The Roles of Chondroitin-4-Sulfotransferase-1 in Development and DiseaseI. Introduction; II. Gene Structure; III. cDNA and Protein Structure of C4ST-1; IV. Enzymatic Activities; V. Homologous Proteins; VI. Expression Pattern of C4ST-1; VII. C4ST-1 in Cellular Signaling Pathways; VIII. Functional Roles of C4ST-1 in Development; IX. C4ST-1 in Disease; X. Concluding Remarks; References; Roles of Heparan Sulfate in Mammalian Brain Development...; I. Introduction; II. Studying Heparan Sulfate Function In Vivo by Genetic Manipulation of Ext1; III. Cre Systems for Studies of Brain Development
- IV. Nestin-Cre-Mediated Ext1 Knockout MiceV. Wnt1-Cre-Mediated Ext1 Knockout Mice; VI. Phenotypic Comparison with Mutant Mice of HS-Modifying Enzymes; VII. Concluding Remarks; References; Anticoagulant Heparan Sulfate; I. Introduction; II. Historical Perspective; III. The Kinetic Mechanisms of AT's Anticoagulant Activity and Heparin Catalysis; IV. Key Features of HSAT+ Biosynthesis; V. Physiological Role of Endothelial HSAT+: To Not Clot-Or Not?; VI. Normal HSAT+ Levels are Not Required for Normal Hemostasis; VII. Data Against HSAT+ as an Anticoagulant