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Omega fatty acids in brain and neurological health
Research has clearly established a link between omega fatty acids and general health, particularly cardiovascular health. Omega Fatty Acids in Brain and Neurological Health, Second Edition, illustrates the importance of omega-3 fatty acids in longevity, cognitive impairment and structure and function of the brain's neurons and also the adverse effects of omega-6 fatty acids on neurological function. This book encompasses some of the most recent research on the links between omega fatty acids and the developing brain, aging, dementia, Alzheimer's disease and multiple sclerosis, including the role of omega-3 fatty acid supplements on hippocampal neurogenesis, substantia nigra modulation, migraine headaches, the developing brain in animals, sleep and neurodegenerative diseases. This completely updated second edition focuses on the counterbalancing dietary and tissue omega-6 fatty acids as well as it studies the effects in pregnancy and early infancy, animal model studies and autoimmune neurological diseases.
Front Cover; Omega Fatty Acids in Brain and Neurological Health; Copyright; Contents; Contributors; Part A: Omega Fatty Acids and Brain: An Overview; Chapter 1: Essentiality of Omega-3 Polyunsaturated Fatty Acids for Mammalian Brain Development: A Translational Perspective; Introduction; Rodent Neurodevelopment; Synaptic Signaling Dynamics; Glutamate; Acetylcholine; Dopamine; Serotonin; Nonhuman Primate Neurodevelopment; Human Neurodevelopment; Summary and Conclusions; References; Chapter 2: Thinking in Polyunsaturated Fatty Acids, Phospholipids, and the Brain; Introduction
The Brain is the Least Enriched With PUFAs Compared to Other Major OrgansBrain Mitochondria Are Also Least Enriched With PUFAs Compared to Other Major Organs; Ischemic Changes to Phospholipid Profiles May Explain the Brain's Unique Vulnerability; Conclusion; References; Chapter 3: The Impact of Omega-3 Fatty Acids on Quality of Life; Introduction; Assessment of QoL; Current Evidence on Omega-3 Fatty Acids and QoL; Evidence From Observational Studies; Evidence From Clinical Trials; Additional Observations From Other Clinical Trials; Discussion; Conclusion and Recommendations; References
Chapter 4: The Balance Between n-6 and n-3 and its Relation to Executive FunctionIntroduction; Evolutionary Perspective; Metabolic Pathways; Importance of n-6/n-3 Balance; Executive Functions; Definition of EF; Neural Substrates Subserving EFs; Medial-Lateral Gradient; Dorsal-Ventral Gradient; Functional Connections; Development; Diffuse to Focal Activity; Integration and Segregation of Function; Balance of FAs and EFs; Inhibitory Control; Working Memory; Planning; Conclusion; References; Chapter 5: Arachidonic Acid, Docosahexaenoic Acid, and Ethanol; Introduction
Phospholipase A 2, AA, and Ethanol in Adult Rat BrainsDHA and Adult Neuroprotection D1; AA, Prostaglandins, and Implantation; Embryonic Oxidative Stress, Apoptosis, and Polyunsaturated Fatty Acids; PLA 2 Activities in Chick Embryos; EtOH-Induced Changes in Brain Membrane Fatty Acids During Late Chick Embryogenesis; Chick Brain DHA Levels; Chick Brain AA Levels; EtOH-Induced Increases in Short Saturated Membrane Fatty Acids; EtOH-Induced Increases in Brain LPO Levels; EtOH-Induced Decreases in Brain Glutathione Levels; EtOH-Induced Increases in Apoptosis Rates
Alcohol Dehydrogenase and Xanthine Oxidase EpistasisAcknowledgments; Ethics Approval; References; Further Reading; Part B: Omega Fatty Acids: Brain and Neurological Development; Chapter 6: Prenatal n-3 Long-Chain Polyunsaturated Fatty Acids and Children's Executive Functions; Introduction; Brain Development; Prenatal Brain Development; Infant and Child Brain Development; The Frontal Lobes; The Executive Functions; Fatty Acids and Brain Development; DHA and Brain Development of Infants Born Preterm; Prenatal DHA RCT's and Brain Development
edited by Ronald Ross Watson, Victor R. Preedy.
Includes bibliographical references and index.