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Curcumin for neurological and psychiatric disorders
neurochemical and pharmacological properties
Curcumin for Neurological and Psychiatric Disorders: Neurochemical and Pharmacological Properties focuses on the different molecular mechanisms underlying curcumin-mediated beneficial effects in neurological diseases. The book's editors discuss the neurochemical and pharmacological properties of curcumin, followed by the effect of curcumin in neurotraumatic diseases, neurodegenerative diseases, and neuropsychiatric diseases. The book also offers a perspective on future studies on the treatment of neurological disorders. The beneficial effects of curcumin have been observed both in cultured cells and in animal models, thus paving the way for ongoing present and future human clinical trials. Curcumin produces antioxidant and anti-inflammatory effects not only by blocking oxidative stress and neuroinflammation in neurotraumatic and neurodegenerative diseases, but also by restoring cellular homeostasis and rebalancing redox equilibrium.
Front Cover; Curcumin for Neurological and Psychiatric Disorders; Copyright Page; Dedication; Contents; List of Contributors; Foreword; Preface; Acknowledgments; Advice; 1 Neurochemical Aspects of Neurological Disorders; Introduction; Classification of Neurological Disorders; Stroke; Spinal Cord Injury; Traumatic Brain Injury; Neurodegenerative Diseases; Alzheimer's Disease; Parkinson's Disease; Huntington's Disease; Amyotrophic Lateral Sclerosis; Neuropsychiatric Disorders; Depression; Autism Spectrum Disorder; Conclusion; References
2 Curcumin: Historical Background, Chemistry, Pharmacological Action, and Potential Therapeutic ValueIntroduction; Historical Background; Chemistry of Curcumin; Curcumin Metabolism; Pharmacological Actions; Antioxidant Activity; Antiinflammatory Activity; Immunomodulatory Effect; Antiapoptotic Effect; Antiexcitotoxic Activity; Antiamyloidogenic Activity; Conclusion; References; 3 Curcumin in Neurological Disorders; Introduction; Curcumin and Neurological Disorders; Curcumin in Stroke; Curcumin and Traumatic Brain Injury; Curcumin and Spinal Cord Injury; Curcumin and Epilepsy
Curcumin and Alzheimer's DiseaseCurcumin and Parkinson's Disease; Curcumin and Huntington's Disease; Curcumin and Depression; Curcumin and Bipolar Disorders; Side Effects of Curcumin; Conclusion; References; 4 Curcumin in Neurological Disorders: An Overview; Introduction; Curcumin and Alzheimer's Disease; Preclinical Studies (Table 4.1) of Curcumin in Alzheimer's Disease; Neuroprotective Studies of Curcumin in Alzheimer's Disease; Curcumin and Insulin Signaling; Miscellaneous Mechanisms of Curcumin; Novel Approaches to Overcome the Bioavailability Issues With Curcumin
Clinical Studies (Table 4.1) of Curcumin in Alzheimer's DiseaseCurcumin and Parkinson's Disease; Curcumin and Migraine Disorders; Conclusion; References; 5 The Potential Role of Curcumin in Treatment and Prevention for Neurological Disorders; Introduction; Epidemiological Studies on Curcumin and Neurological Disorders; Experimental Studies With Curcumin in Alzheimer's Disease Models; Antiamyloid Genic Effects In Vitro; Antioxidative Effects In Vitro; Antiinflammatory Effects In Vitro; In Vivo Studies; Experimental Studies With Curcumin in Parkinson's Disease Models
Experimental Studies With Curcumin in Other Neurological DisordersAmyotrophic Lateral Sclerosis; Hungtington's Disease; Multiple Sclerosis; Pharmacokinetic Studies With Curcumin in Humans and New Formulations of Curcumin; Safety and Tolerability of Curcumin; Bioavailability and Pharmacokinetics of Curcumin; Improvement of Bioavailability and New Formulations of Curcumin; Randomized Clinical Trials With Curcumin for Neurological Disorders; Alzheimer's Disease; Amyotrophic Lateral Sclerosis; Conclusions; References
edited by Tahira Farooqui, Akhlaq A. Farooqui.
Includes bibliographical references and index.
London, United Kingdom : Academic Press, an imprint of Elsevier, [2019]